Extensive-stage Small Cell Lung Cancer
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Organoid-guided vs Topotecan Therapy in Relapsed Extensive-Stage Small Cell Lung Cancer [Phase 2, Phase 3]
A phase 2/3 clinical trial update comparing organoid-guided therapy to Topotecan for relapsed extensive-stage small cell lung cancer, with t…
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CLINICAL_TRIALS research · 2025-07-24Clinical Trial Update: A Phase II Study of QL1706 With Anti-angiogenesis Therapy and Chemotherapy in Extensive-stage Small Cell Lung Cancer. [Phase 2]
A Phase II clinical trial studying QL1706 combined with anti-angiogenesis therapy and chemotherapy in extensive-stage small cell lung cancer…
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CLINICAL_TRIALS trial_result · 2025-07-23Clinical Trial Update: Efficacy and Safety of Pembrolizumab Plus Investigational Agents in Combination With Chemotherapy as First-Line Treatment in Extensive-Stage Small Cell Lung Cancer (ES-SCLC) (MK-3475-B99/ KEYNOTE-B99) [Phase 2]
Phase 2 results evaluate pembrolizumab in combination with chemotherapy and investigational agents as first-line therapy for extensive-stage…
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CLINICAL_TRIALS research · 2025-07-17Clinical Trial Update: Small Extracellular Vesicle miRNAs as Predictive Biomarkers for Immunochemotherapy Efficacy in Extensive-stage Small Cell Lung Cancer
A clinical trial is currently recruiting to evaluate whether small extracellular vesicle miRNAs can serve as predictive biomarkers for the e…
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CLINICAL_TRIALS trial_result · 2025-07-11Clinical Trial Update: Sintilimab Combined With Tafolecimab and Chemotherapy as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer [Phase 2]
Phase 2 trial assessing the combination of sintilimab and tafolecimab with chemotherapy as first-line treatment for extensive-stage small ce…
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Phase I Clinical Study of SHR-1316 (SC) Combined With Carboplatin and Etoposide as First-line Treatment for Extensive Stage Small Cell Lung Cancer [Phase 1]
Phase I study SHR-1316 combined with carboplatin and etoposide as first-line treatment for extensive-stage small cell lung cancer is current…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Pembrolizumab and Olaparib Treatment of Extensive Small Cell Lung Cancer (ES-SCLC) [Phase 2]
This clinical trial update notes recruitment for a Phase 2 study evaluating the combination of pembrolizumab and olaparib in extensive-stage…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Nano-crystalline Megestrol Acetate Combined With Standard Treatment Versus Standard Treatment for First-line Extensive-stage Small Cell Lung Cancer in the Cachexia Phase [Phase 3]
Phase 3 clinical trial evaluating adding nano-crystalline megestrol acetate to standard therapy versus standard therapy alone as first-line …
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Extensive-stage Small Cell Lung Cancer [Phase 2]
Phase 2 clinical trial evaluating BL-B01D1 in combination with an anti-PD-1 monoclonal antibody for extensive-stage small cell lung cancer; …
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CLINICAL_TRIALS research · 2025-04-23Clinical Trial Update: Benmelstobart, Anlotinib and Chemotherapy as First-line Treatment for Extensive-stage Small-cell Lung Cancer [Phase 4]
A Phase 4 clinical trial evaluating Benmelstobart and Anlotinib in combination with chemotherapy as first-line treatment for extensive-stage…
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CLINICAL_TRIALS trial_result · 2025-04-03Clinical Trial Update: Nanocrystalline Megestrol Acetate for the Treatment of Anorexia-Cachexia Syndrome in Extensive-Stage Small Cell Lung Cancer: A Prospective, Open-Label, Single-Arm Phase II Clinical Study [Phase 2]
This document describes a Phase II prospective, open-label, single-arm trial evaluating nanocrystalline megestrol acetate for cancer-associa…
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CLINICAL_TRIALS trial_result · 2025-03-27Clinical Trial Update: Study of AZD2811 + Durvalumab in ES-SCLC [Phase 2]
A Phase 2 clinical trial evaluating the combination of AZD2811 and durvalumab for extensive-stage small cell lung cancer is active/not recru…
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CLINICAL_TRIALS trial_result · 2025-03-18Clinical Trial Update: Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT411 [Phase 1, Phase 2]
Phase 1/2 trial of BNT411 in solid tumors and extensive-stage small cell lung cancer reported safety, pharmacokinetics, pharmacodynamics, an…
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CLINICAL_TRIALS research · 2025-03-13Clinical Trial Update: Atezolizumab and Rechallenge Chemotherapy in Relapsed Patients With Extensive-stage Small Cell Lung Cancer (ES-SCLC). [Phase 2]
Phase 2 clinical trial evaluating atezolizumab with rechallenge chemotherapy in relapsed extensive-stage small cell lung cancer; currently r…
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CLINICAL_TRIALS trial_result · 2025-03-12Clinical Trial Update: A Study of PM8002 (Anti-PD-L1/VEGF) in Combination With Chemotherapy in Patients With ES-SCLC [Phase 2]
Updates on a Phase 2 study of PM8002 (anti-PD-L1/VEGF) in combination with chemotherapy for extensive-stage small cell lung cancer, with the…
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CLINICAL_TRIALS research · 2025-03-03Clinical Trial Update: Second-line Immunotherapy for ES-SCLC [NA]
A second-line immunotherapy trial (NCT06853678) for extensive-stage small cell lung cancer is currently recruiting at Tianjin Medical Univer…
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CLINICAL_TRIALS trial_result · 2025-02-27Clinical Trial Update: Real-world First-line Serplulimab-based Immunochemotherapy for Extensive-stage Small Cell Lung Cancer
Real-world update on first-line serplulimab-based immunochemotherapy for extensive-stage small cell lung cancer; the study is currently acti…
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CLINICAL_TRIALS research · 2025-01-27Clinical Trial Update: Nanocrystalline Megestrol + Immunochemo As 1st-Line for ES-SCLC Cachexia [Phase 2]
A Phase 2 trial of nanocrystalline Megestrol plus an immunochemotherapy regimen as first-line therapy for cachexia in extensive-stage small …
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CLINICAL_TRIALS trial_result · 2025-01-17Clinical Trial Update: Safety and Efficacy Study of First-line Treatment With QL1706 Plus Chemotherapy in Extensive-Stage Small Cell Lung Cancer [Phase 2]
A Phase 2 safety and efficacy study evaluating QL1706 in combination with chemotherapy as first-line treatment for extensive-stage small cel…
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CLINICAL_TRIALS research · 2025-01-17Clinical Trial Update: First Line Therapy for Extensive SCLC Patients, Treated with Chemo+Keytruda Followed by Keytuda+Trodelvy [Phase 2]
Ongoing Phase 2 trial evaluating first-line chemotherapy plus pembrolizumab, followed by pembrolizumab plus sacituzumab govitecan in extensi…
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CLINICAL_TRIALS research · 2025-01-10Clinical Trial Update: Assessment of Adebelizumab Combined with Chemotherapy in Concurrent Radiotherapy Versus Sequential Radiotherapy As First-Line Treatment for Extensive-Stage Small Cell Lung Cancer [Phase 2]
A Phase 2 clinical trial evaluates Adebelizumab in combination with chemotherapy, with concurrent versus sequential radiotherapy as first-li…
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CLINICAL_TRIALS research · 2025-01-10Clinical Trial Update: Phase II Study of Ivonescimab and Cadonilimab in Combination with Chemotherapy in Patients with ES-SCLC [Phase 2]
This is a Phase II clinical trial evaluating Ivonescimab and Cadonilimab in combination with chemotherapy for extensive-stage small cell lun…
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CLINICAL_TRIALS trial_result · 2025-01-07Clinical Trial Update: Durvalumab Plus Chemotherapy in Untreated Patients With Extensive-Stage Small Cell Lung Cancer [Phase 3]
Phase 3 trial evaluating durvalumab plus chemotherapy in untreated extensive-stage small cell lung cancer has completed and posted results i…
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CLINICAL_TRIALS research · 2025-01-06Clinical Trial Update: Adebrelimab Plus Apatinib for Maintenance Therapy of Extensive Stage Small Cell Lung Cancer [NA]
A recruiting clinical trial evaluating the combination of Adebrelimab and Apatinib as maintenance therapy for extensive-stage small cell lun…
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CLINICAL_TRIALS trial_result · 2024-12-30Clinical Trial Update: Liver Directed RT + Chemo-immunotherapy for ES-SCLC [Phase 2]
Phase 2 trial of liver-directed radiotherapy combined with chemo-immunotherapy for extensive-stage small cell lung cancer has been terminate…