Extensive-stage Small Cell Lung Cancer
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: Chemo-Immunotherapy Followed by Durvalumab and Ceralasertib in Treatment Naïve Patients With Extensive Stage Small Cell Lung Cancer [Phase 2]
A Phase 2 clinical trial is evaluating chemo-immunotherapy followed by durvalumab and Ceralasertib in treatment-naïve patients with extensiv…
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Adebrelimab Combine With Etoposide Capsules in ES-SCLC Maintenance Therapy [Phase 2]
A Phase 2 trial is evaluating adebrelimab in combination with etoposide capsules as maintenance therapy for extensive-stage small cell lung …
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: Real-World Study of Toripalimab in Extensive-Stage Small Cell Lung Cancer
This entry notes a real-world study of toripalimab for extensive-stage small cell lung cancer, with the study currently not recruiting.
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Olaparib and Durvalumab With Carboplatin, Etoposide, and/or Radiation Therapy for the Treatment of Extensive-Stage Small Cell Lung Cancer, PRIO Trial [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating Olaparib and Durvalumab with carboplatin, etoposide, and optional radiation therapy for extensive-stage …
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CLINICAL_TRIALS trial_result · 2025-12-17Clinical Trial Update: A Prospective, Single-Arm, Exploratory Study of IBI363 in ES-SCLC Patients After Immunotherapy Progression [Phase 2]
This document reports a Phase 2 prospective, single-arm exploratory study evaluating the investigational drug IBI363 in patients with extens…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab [Phase 3]
A Phase 3 trial is evaluating Tarlatamab plus Durvalumab versus Durvalumab alone as first-line therapy for extensive-stage small-cell lung c…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Lamivudine in Combination With Chemoimmunotherapy for the Treatment of Extensive Stage Small Cell Lung Cancer [Phase 2]
This clinical trial update describes a Phase 2 study evaluating lamivudine in combination with chemoimmunotherapy for extensive-stage small …
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CLINICAL_TRIALS trial_result · 2025-12-09Clinical Trial Update: A Phase III Study to Investigate Efficacy and Safety of HLX10 + Chemotherapy in Patients With ES-SCLC [Phase 3]
Phase III study evaluating HLX10 in combination with chemotherapy for extensive-stage small cell lung cancer has completed and posted result…
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CLINICAL_TRIALS research · 2025-12-05Clinical Trial Update: Post-line Treatment With Teniposide for c-Myc-driven Extensive-stage Small Cell Lung Cancer [Phase 2]
Phase 2 clinical trial update evaluating post-line treatment with teniposide for c-Myc-driven extensive-stage small cell lung cancer; recrui…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Olvi-Vec Combined With Platinum Plus Etoposide Therapy in Patients With Late Phase SCLC [Phase 1, Phase 2]
A clinical trial update indicates an ongoing Phase 1/Phase 2 study of Olvi-Vec in combination with platinum-based chemotherapy and etoposide…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Subcutaneous Tarlatamab in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-308) [Phase 1]
A Phase 1 study evaluating subcutaneous tarlatamab in patients with extensive-stage small cell lung cancer is currently recruiting.
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: A Study of Ivonescimab in First-Line ES-SCLC [Phase 2]
A Phase 2 study evaluating Ivonescimab as first-line treatment in extensive-stage small cell lung cancer is currently recruiting.
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Clinical Study on Using TCR to Predict the Effect of Tislelizumab + Chemotherapy in the First-line Treatment of ES-SCLC
Clinical trial update for a study using T-cell receptor profiling to predict response to tislelizumab plus chemotherapy as first-line treatm…
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Study of Bevacizumab in Combination With Chemoimmunotherapy and Atezolizumab in Patients With Extensive Stage Small Cell Lung Cancer and Liver Metastases [Phase 2]
A Phase 2 clinical trial testing bevacizumab in combination with chemoimmunotherapy and atezolizumab for extensive-stage small-cell lung can…
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CLINICAL_TRIALS research · 2025-10-22Clinical Trial Update: Personalized Neoantigen Vaccine in Combination With Durvalumab (MEDI4736) in Extensive Stage Small Cell Lung Cancer [Phase 2]
This clinical trial update describes a Phase 2 study evaluating a personalized neoantigen vaccine in combination with durvalumab (MEDI4736) …
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CLINICAL_TRIALS research · 2025-10-21Clinical Trial Update: To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC [Phase 3]
A Phase 3 clinical trial evaluating serplulimab in combination with carboplatin and etoposide for efficacy and safety in US patients with ex…
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: A Study of BMS-986012 in Combination With Carboplatin, Etoposide, and Nivolumab as First-line Therapy in Extensive-stage Small Cell Lung Cancer [Phase 2]
A Phase 2 clinical trial evaluating BMS-986012 in combination with carboplatin, etoposide, and nivolumab as first-line therapy for extensive…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Open-Label, Biomarker-Integrated Umbrella Trial for First-Line Treatment of Extensive-stage Small Cell Lung Cancer [Phase 2]
Open-label Phase 2 umbrella trial from Tianjin Medical University Cancer Institute and Hospital investigating first-line treatment options f…
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Tislelizumab Combined With Chemotherapy and Relayed Radiotherapy in First-line Treatment of ES-SCLC [Phase 2]
A Phase 2 clinical trial is evaluating tislelizumab in combination with chemotherapy and radiotherapy as first-line treatment for extensive-…
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Prospective Observational Study on ES-SCLC
A prospective observational study on extensive-stage and small cell lung cancer conducted by Peking Union Medical College Hospital is not ye…
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CLINICAL_TRIALS trial_result · 2025-09-08Clinical Trial Update: Patients With ES-SCLC and ECOG PS=2 Receiving Atezolizumab-Carboplatin-Etoposide [Phase 2]
A Phase 2 trial evaluating atezolizumab with carboplatin and etoposide in extensive-stage small cell lung cancer patients with ECOG performa…
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CLINICAL_TRIALS trial_result · 2025-09-05Clinical Trial Update: A Study of hSTC810 in Combination With Paclitaxel in Relapsed or Refractory Extensive Stage Small Cell Lung Cancer [Phase 1, Phase 2]
A Phase 1/2 trial of hSTC810 with paclitaxel in relapsed or refractory extensive-stage small cell lung cancer has been terminated.
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CLINICAL_TRIALS trial_result · 2025-09-04Clinical Trial Update: Trilaciclib vs Placebo in Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC) Receiving Topotecan [Phase 4]
Phase 4 clinical trial comparing trilaciclib versus placebo in patients with extensive-stage small cell lung cancer receiving topotecan is c…
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CLINICAL_TRIALS trial_result · 2025-08-29Clinical Trial Update: Surufatinib Plus Anti-PD-1/L1 as Maintenance Therapy in Extensive-Stage Small Cell Lung Cancer [Phase 2]
Phase 2 clinical trial evaluating surufatinib plus anti-PD-1/PD-L1 as maintenance therapy in extensive-stage small cell lung cancer has been…
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CLINICAL_TRIALS research · 2025-08-26Clinical Trial Update: Chemotherapy and Immunotherapy in Extensive-Stage Small-Cell Lung Cancer With Thoracic Radiotherapy [Phase 2]
An ongoing Phase 2 trial is evaluating chemotherapy and immunotherapy with thoracic radiotherapy in extensive-stage small-cell lung cancer.