Diffuse Midline Glioma H3 K27-altered
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study) [Phase 3]
A Phase 3 clinical trial (ACTION) evaluating ONC201 for H3 K27M-mutant diffuse glioma following radiotherapy is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma [Phase 1]
A Phase 1 trial evaluating genetically modified KIND T cells for HLA-A*0201-positive patients with diffuse midline glioma harboring H3 K27 m…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Targeted Pediatric High-Grade Glioma Therapy
A pediatric clinical trial is currently recruiting to evaluate a targeted therapy for high-grade gliomas, including diffuse intrinsic pontin…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas [Phase 2]
This clinical trial update describes a Phase 2 study of ACT001 for diffuse intrinsic pontine glioma and H3K27-altered diffuse midline glioma…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma [Phase 1, Phase 2]
This entry reports a Phase 1/2 clinical trial evaluating CBL0137 for relapsed or refractory solid tumors, including central nervous system t…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating a combination of ADI-PEG 20, temozolomide, and radiotherapy for newly diagnosed high-grade glioma, …
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0 [Phase 3]
A Phase 3 clinical trial evaluating a biological medicine for diffuse intrinsic pontine glioma and related diffuse midline gliomas is curren…
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CLINICAL_TRIALS trial_result · 2025-11-19Clinical Trial Update: Phase I Pilot Study to Evaluate the Anti-glioblastoma Effect of S-Gboxin in Standard Treatment of Glioblastoma/Diffuse Midline Glioma and Response to Treatment (Regardless of Mutation Status) [Phase 1]
A Phase I pilot study evaluating S-Gboxin in combination with standard glioblastoma therapy; the trial assessing anti-glioblastoma effects i…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: A Study of 177Lu-PSMA-617 in People With Gliomas [Phase 1]
A Phase 1 clinical trial is evaluating 177Lu-PSMA-617 in patients with gliomas and related subtypes and is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-07-28Clinical Trial Update: ONC201 in Adults With Recurrent H3 K27M-mutant Glioma [Phase 2]
Jazz Pharmaceuticals’ ONC201 phase 2 trial in adults with recurrent H3 K27M-mutant diffuse midline glioma has been terminated, and results h…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG) [Phase 1]
A Phase 1 trial evaluating non-invasive focused ultrasound in combination with oral panobinostat for children with progressive diffuse midli…
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CLINICAL_TRIALS research · 2025-02-21Clinical Trial Update: Study of Olutasidenib and Temozolomide in HGG [Phase 2]
Phase 2 study evaluating olutasidenib in combination with temozolomide for high-grade gliomas is currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-11-08Clinical Trial Update: Expanded Access to OKN-007 for Patients With Diffuse Midline Glioma, H3 K27-altered
Expanded Access for OKN-007 in patients with diffuse midline glioma (H3 K27-altered) and diffuse intrinsic pontine glioma is no longer avail…