Diffuse Intrinsic Pontine Glioma
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CLINICAL_TRIALS trial_result · 2024-12-05Clinical Trial Update: Re-Irradiation of Progressive or Recurrent DIPG [NA]
A completed clinical trial investigating re-irradiation for recurrent or progressive diffuse intrinsic pontine glioma (DIPG) conducted by th…
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CLINICAL_TRIALS trial_result · 2024-11-08Clinical Trial Update: Expanded Access to OKN-007 for Patients With Diffuse Midline Glioma, H3 K27-altered
Expanded Access for OKN-007 in patients with diffuse midline glioma (H3 K27-altered) and diffuse intrinsic pontine glioma is no longer avail…
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: Phase I Study of APX005M in Pediatric Central Nervous System Tumors [Phase 1]
Phase I study of APX005M in pediatric central nervous system tumors; the trial is active but not recruiting and results have been posted. Sp…
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CLINICAL_TRIALS trial_result · 2024-10-09Clinical Trial Update: REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma [Phase 1, Phase 2]
Regeneron’s cemiplimab (REGN2810) was studied in pediatric patients with relapsed/refractory solid tumors and CNS tumors, including a safety…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients with DIPG [Phase 2]
Phase 2 study of SONALA-001 with Exablate 4000 Type 2.0 for diffuse intrinsic pontine glioma and diffuse midline glioma has been suspended.
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CLINICAL_TRIALS trial_result · 2024-07-05Clinical Trial Update: A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas [Phase 1, Phase 2]
A Phase I/Phase II study evaluating mebendazole for pediatric gliomas has completed. It enrolled children with various glial tumors, includi…
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CLINICAL_TRIALS trial_result · 2024-04-25Clinical Trial Update: Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma [Phase 1]
Phase 1 trial of panobinostat in children with diffuse intrinsic pontine glioma has completed. Results have been posted.
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CLINICAL_TRIALS trial_result · 2024-01-03Clinical Trial Update: Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas [Phase 1]
Phase 1 trial evaluating adavosertib with local radiation in children with newly diagnosed diffuse intrinsic pontine glioma; results are pos…
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CLINICAL_TRIALS trial_result · 2023-12-06Clinical Trial Update: Study of Re-irradiation at Relapse Versus RT and Multiple Elective rt Courses [Phase 2]
Phase 2 trial evaluating re-irradiation at relapse versus standard RT and multiple elective RT courses for diffuse intrinsic pontine glioma …
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CLINICAL_TRIALS trial_result · 2023-07-27Clinical Trial Update: Nimotuzumab in Combined With Chemoradiotherapy to Treat the Newly Diagnosed Diffuse Intrinsic Pontine Glioma in Children [Phase 3]
A Phase 3 clinical trial evaluating nimotuzumab combined with chemoradiotherapy for newly diagnosed diffuse intrinsic pontine glioma in chil…
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CLINICAL_TRIALS trial_result · 2022-08-09Clinical Trial Update: Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 [Phase 1, Phase 2]
Phase 1/2 trial evaluating intraarterial cetuximab (Erbitux) and bevacizumab for relapsed/refractory intracranial glioma in patients under 2…
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CLINICAL_TRIALS trial_result · 2022-06-06Clinical Trial Update: International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013) [Phase 3]
International Phase III trial HIT-HGG-2013 update; no results or status publicly available yet.
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CLINICAL_TRIALS trial_result · 2022-04-12Clinical Trial Update: A Study of DSP-7888 in Pediatric Patients With Relapsed or Refractory High Grade Gliomas [Phase 1, Phase 2]
Phase 1/2 trial of DSP-7888 in pediatric patients with relapsed or refractory high-grade gliomas has completed.
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CLINICAL_TRIALS trial_result · 2022-02-25Clinical Trial Update: MTX110 by Convection-Enhanced Delivery in Treating Participants With Newly-Diagnosed Diffuse Intrinsic Pontine Glioma [Phase 1, Phase 2]
Phase 1/2 clinical trial update for MTX110 delivered via convection-enhanced delivery in newly diagnosed diffuse intrinsic pontine glioma ha…
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CLINICAL_TRIALS trial_result · 2021-08-27Clinical Trial Update: Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors [Phase 1]
Phase 1 trial evaluating ribociclib with everolimus in pediatric patients with recurrent or refractory malignant brain tumors; completed wit…
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CLINICAL_TRIALS trial_result · 2021-07-21Clinical Trial Update: Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma [Phase 2]
Phase 2 trial evaluating valproic acid with radiation and bevacizumab in pediatric high-grade gliomas and diffuse intrinsic pontine glioma h…
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CLINICAL_TRIALS trial_result · 2020-11-05Clinical Trial Update: A Phase I/II Study of Ribociclib,a CDK4/6 Inhibitor, Following Radiation Therapy [Phase 1, Phase 2]
Phase I/II study of ribociclib (CDK4/6 inhibitor) following radiation therapy in high-grade glioma and DIPG was terminated; results posted.
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CLINICAL_TRIALS trial_result · 2020-03-03Clinical Trial Update: Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma [Phase 1, Phase 2]
Phase 1/2 trial evaluating Vorinostat with radiation followed by maintenance therapy in younger patients with newly diagnosed diffuse intrin…
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CLINICAL_TRIALS trial_result · 2019-09-04Clinical Trial Update: Molecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG) [Phase 2]
Phase 2 trial for molecularly determined treatment in diffuse intrinsic pontine glioma (DIPG) has been terminated; results posted in 2019.
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CLINICAL_TRIALS trial_result · 2018-05-02Clinical Trial Update: A Study of Bevacizumab Therapy in Patients With Newly Diagnosed High-Grade Gliomas and Diffuse Intrinsic Pontine Gliomas [EARLY_Phase 1]
This early-phase trial evaluated bevacizumab in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine glioma; the s…
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CLINICAL_TRIALS trial_result · 2017-04-26Clinical Trial Update: PDGFR Inhibitor Crenolanib in Children/Young Adults With Diffuse Intrinsic Pontine Glioma or Recurrent High-Grade Glioma [Phase 1]
Phase 1 trial of crenolanib, a PDGFR inhibitor, in pediatric patients with Diffuse Intrinsic Pontine Glioma or recurrent high-grade glioma h…
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CLINICAL_TRIALS trial_result · 2016-10-28Clinical Trial Update: Erivedge (Vismodegib) in the Treatment of Pediatric Patients With Refractory Pontine Glioma [Phase 2]
This ClinicalTrials.gov update reports results from a Phase 2 study of vismodegib (Erivedge) in pediatric patients with refractory diffuse i…
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CLINICAL_TRIALS trial_result · 2016-07-26Clinical Trial Update: DNA Analysis of Tumor Tissue Samples From Patients With Diffuse Brain Stem Glioma
This clinical trial update reports on DNA analysis of tumor tissue samples from patients with diffuse intrinsic pontine glioma, a form of di…
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CLINICAL_TRIALS trial_result · 2015-07-21Clinical Trial Update: Cilengitide and Metronomic Temozolomide for Relapsed or Refractory High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas in Children and Adolescents [Phase 2]
Phase 2 trial in children tested cilengitide with metronomic temozolomide for relapsed or refractory high-grade gliomas and diffuse intrinsi…
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CLINICAL_TRIALS trial_result · 2015-04-21Clinical Trial Update: Palliative Re-irradiation for Progressive Diffuse Intrinsic Pontine Glioma (DIPG) in Children [Phase 1, Phase 2]
A completed phase 1/phase 2 clinical trial evaluated palliative re-irradiation for progressive diffuse intrinsic pontine glioma in children.