Diffuse Hemispheric Glioma H3 G34-mutant

• CLINICAL_TRIALS trial_result · 2026-04-24
  Clinical Trial Update: Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma [Phase 1]

  A Phase 1 trial evaluating Triapine in combination with radiation therapy for recurrent glioblastoma or astrocytoma has been suspended.

• CLINICAL_TRIALS research · 2026-04-22
  Clinical Trial Update: Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant [Phase 2]

  Phase 2 clinical trial exploring ribociclib with everolimus or with temozolomide for high-grade gliomas and related diffuse gliomas; recruit…

• CLINICAL_TRIALS trial_result · 2026-03-11
  Clinical Trial Update: Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors [Phase 1]

  Phase 1 study of virus-based gene therapy with AdV-HSV1-TK and AdV-Flt3L, combined with valacyclovir, for pediatric and young adult patients…

• CLINICAL_TRIALS research · 2026-02-17
  Clinical Trial Update: A Vaccine (Neoantigen-Targeted ppDC) for the Treatment of H3 G34-mutant Diffuse Hemispheric Glioma [Phase 1]

  Phase 1 trial evaluating a neoantigen-targeted ppDC vaccine for diffuse hemispheric glioma with H3 G34 mutation.

• CLINICAL_TRIALS research · 2026-02-05
  Clinical Trial Update: Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) [Phase 1, Phase 2]

  A Phase 1/2 clinical trial is evaluating a combination of ADI-PEG 20, temozolomide, and radiotherapy for newly diagnosed high-grade glioma, …

• Want full summaries, importance scores, and drug timelines? Upgrade to Plus or Pro.
• CLINICAL_TRIALS research · 2026-01-21
  Clinical Trial Update: 5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours [Phase 1, Phase 2]

  A Phase 1/2 clinical trial evaluating the combination of Avutometinib and Defactinib in malignant brain tumors is currently recruiting.

• CLINICAL_TRIALS research · 2025-11-04
  Clinical Trial Update: A Study of 177Lu-PSMA-617 in People With Gliomas [Phase 1]

  A Phase 1 clinical trial is evaluating 177Lu-PSMA-617 in patients with gliomas and related subtypes and is currently recruiting.

• CLINICAL_TRIALS research · 2025-06-26
  Clinical Trial Update: Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma [Phase 1]

  Phase 1 clinical trial update evaluating intrathecal azacitidine in combination with nivolumab for recurrent high-grade glioma. The study is…

• CLINICAL_TRIALS research · 2025-04-25
  Clinical Trial Update: 5G-EMERALD: Amivantamab in Malignant Brain Tumours [Phase 1]

  A Phase 1 clinical trial of amivantamab for malignant brain tumors, including glioblastoma and related gliomas, is currently recruiting in t…

• CLINICAL_TRIALS withdrawal · 2025-02-24
  Clinical Trial Update: Peptide-Pulsed Dendritic Cell Vaccination in Combination With Nivolumab and Ipilimumab for the Treatment of Recurrent and/or Progressive Diffuse Hemispheric Glioma, H3 G34-mutant [Phase 1]

  The Phase 1 trial of a peptide-pulsed dendritic cell vaccine in combination with nivolumab and ipilimumab for diffuse hemispheric glioma, H3…