Cystic Fibrosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2013-09-02Clinical Trial Update: The Effect of rhDNase on Ventilation Inhomogeneity in Patients With Cystic Fibrosis [Phase 4]
Phase 4 trial evaluating the effect of inhaled recombinant human DNase (dornase alfa / Pulmozyme) on ventilation inhomogeneity in patients w…
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CLINICAL_TRIALS research · 2013-07-31Clinical Trial Update: Retrospective Observational Study to Compare Cystic Fibrosis Patients in Two Decades Before and After 2000
A retrospective observational study comparing cystic fibrosis patients from two decades before and after 2000 to assess changes over time.
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CLINICAL_TRIALS trial_result · 2013-07-19Clinical Trial Update: A Safety and Tolerability Study OF PUR118 In Subjects With Cystic Fibrosis [Phase 1]
A Phase 1 safety and tolerability study of PUR118 in subjects with cystic fibrosis has completed.
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FDA approval · 2013-06-03FDA Approved: KALYDECO — Supplemental Application (Vertex Pharmaceuticals Incorporated)
FDA approves Vertex's supplemental application for KALYDECO (ivacaftor), resulting in updated labeling for additional cystic fibrosis indica…
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CLINICAL_TRIALS trial_result · 2013-05-30Clinical Trial Update: Comparison of Airway Clearance Efficacy of Two High Frequency Chest Wall Oscillation (HFCWO) Devices in Cystic Fibrosis [NA]
The trial compared the airway clearance effectiveness of two high-frequency chest wall oscillation devices in cystic fibrosis patients. The …
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CLINICAL_TRIALS trial_result · 2013-05-22Clinical Trial Update: A Study in Pediatric Patients With Cystic Fibrosis Lung Disease [Phase 2]
A Phase 2 clinical trial in pediatric cystic fibrosis lung disease sponsored by Merck Sharp & Dohme LLC has completed.
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FDA approval · 2013-04-11FDA Approved: ZENPEP — Supplemental Application (Aimmune Therapeutics, Inc.)
The FDA approved a supplemental application for ZENPEP (pancrelipase) submitted by Aimmune Therapeutics.
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CLINICAL_TRIALS trial_result · 2013-03-29Clinical Trial Update: Aurexis® in Cystic Fibrosis Subjects Chronically Colonized With Staphylococcus Aureus in Their Lungs [Phase 2]
Phase 2 trial evaluating Aurexis in cystic fibrosis patients chronically colonized with Staphylococcus aureus in the lungs completed.
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CLINICAL_TRIALS trial_result · 2013-03-26Clinical Trial Update: Tiotropium Bromide in Cystic Fibrosis [Phase 3]
Phase 3 trial of tiotropium bromide in cystic fibrosis has completed. Boehringer Ingelheim posted the trial results in March 2013.
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FDA approval · 2013-03-22FDA Approved: TOBI PODHALER — Original Application (Viatris Specialty LLC)
FDA approved TOBI PODHALER (tobramycin inhalation powder) via an Original Application submitted by Viatris Specialty LLC.
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CLINICAL_TRIALS trial_result · 2013-03-21Clinical Trial Update: Sino-nasal Inhalation of Colistin in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Colonization [Phase 2]
Phase 2 trial evaluating sino-nasal inhaled colistin in cystic fibrosis patients with Pseudomonas aeruginosa colonization has completed.
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CLINICAL_TRIALS trial_result · 2013-03-15Clinical Trial Update: NAC Phase IIB: A Multi-Center, Phase IIB, Randomized, Placebo-controlled, Double-Blind Study Of The Effects Of N-Acetylcysteine On Redox Changes and Lung Inflammation In Cystic Fibrosis Patients [Phase 2]
A Phase II randomized, double-blind, placebo-controlled trial assessed the effects of N-acetylcysteine on redox changes and lung inflammatio…
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FDA approval · 2013-03-14FDA Approved: CREON — Supplemental Application (AbbVie Inc.)
FDA approved a supplemental application for CREON (pancrelipase) by AbbVie.
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CLINICAL_TRIALS research · 2013-03-07Clinical Trial Update: Detection of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity in Rectal Tissues From Human Subjects
A completed clinical trial reports methods for detecting CFTR activity in rectal tissues from humans, in the context of cystic fibrosis.
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CLINICAL_TRIALS trial_result · 2013-02-22Clinical Trial Update: Intraduodenal Aspiration Study to Assess the Bioavailability of Oral Pancrecarb® Compared to Placebo Control [Phase 4]
Phase 4 intraduodenal aspiration study evaluating the bioavailability of the oral pancrecarb versus placebo in exocrine pancreatic insuffici…
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CLINICAL_TRIALS trial_result · 2013-02-20Clinical Trial Update: Effect of Lucinactant on Mucus Clearance in Cystic Fibrosis Lung Disease [Phase 2]
Phase 2 trial evaluating lucinactant for mucus clearance in cystic fibrosis has completed and results are posted.
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CLINICAL_TRIALS trial_result · 2013-02-13Clinical Trial Update: Effect of Non-Invasive Ventilation in Cystic Fibrosis Patient With Chronic Respiratory Failure. [Phase 4]
A Phase 4 trial evaluating non-invasive ventilation in cystic fibrosis patients with chronic respiratory failure has been terminated.
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CLINICAL_TRIALS trial_result · 2013-02-12Clinical Trial Update: Infant Study of Inhaled Saline in Cystic Fibrosis [NA]
The document notes the completion of an infant study evaluating inhaled saline in cystic fibrosis. No study results are provided in the snip…
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CLINICAL_TRIALS trial_result · 2013-01-30Clinical Trial Update: Study of the Effect of Ivacaftor on Lung Clearance Index in Subjects With Cystic Fibrosis and the G551D Mutation [Phase 2]
This is a Phase 2 trial update. It studied the effect of ivacaftor on Lung Clearance Index in cystic fibrosis patients with the G551D CFTR m…
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CLINICAL_TRIALS trial_result · 2013-01-30Clinical Trial Update: Study of Long-term Treatment With Hypertonic Saline in Patients With Cystic Fibrosis [Phase 4]
A Phase 4 clinical trial update indicates the long-term hypertonic saline treatment study in cystic fibrosis patients has completed.
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CLINICAL_TRIALS trial_result · 2013-01-28Clinical Trial Update: IGF-1 Therapy in Patients With Cystic Fibrosis [Phase 1]
A Phase 1 trial evaluating IGF-1 therapy in cystic fibrosis patients has been terminated.
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CLINICAL_TRIALS trial_result · 2013-01-15Clinical Trial Update: Growth Hormone Therapy for Wasting in Cystic Fibrosis [Phase 1]
Phase 1 study of recombinant growth hormone for wasting in cystic fibrosis was terminated; results were posted in 2013.
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CLINICAL_TRIALS trial_result · 2013-01-14Clinical Trial Update: Study of LYM-X-SORB™ to Improve Fatty Acid and Choline Status in Children With CF and PI [Phase 2]
A Phase 2 clinical trial evaluating LYM-X-SORB to improve fatty acid and choline status in children with cystic fibrosis and pancreatic insu…
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CLINICAL_TRIALS trial_result · 2013-01-11Clinical Trial Update: Study of Individualized Physiotherapy for Airway Clearance in Cystic Fibrosis. [NA]
The Oslo University Hospital-sponsored study evaluating individualized physiotherapy for airway clearance in cystic fibrosis has completed.
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CLINICAL_TRIALS research · 2012-12-18Clinical Trial Update: Switching From Tobramycin Inhalation Treatment to Tobramycin Inhaler Treatment: The Effect on CF Patients' Adherence and Quality of Life
Clinical trial evaluating how switching cystic fibrosis patients from inhaled to tobramycin inhaler affects adherence and quality of life; s…