Cystic Fibrosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2017-04-06Clinical Trial Update: Costimulatory Molecules as Biomarkers in Cystic Fibrosis
A clinical trial evaluating costimulatory molecules as biomarkers in cystic fibrosis has completed under the sponsorship of Oregon Health an…
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CLINICAL_TRIALS trial_result · 2017-04-04Clinical Trial Update: Viral Pathogenesis of Early Cystic Fibrosis Lung Disease
A completed clinical trial update from Indiana University School of Medicine examining viral pathogenesis in early cystic fibrosis lung dise…
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CLINICAL_TRIALS trial_result · 2017-03-30Clinical Trial Update: Doxycycline Effects on Inflammation in Cystic Fibrosis [Phase 4]
A Phase 4 clinical trial evaluating doxycycline's effect on inflammation in cystic fibrosis has completed.
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CLINICAL_TRIALS trial_result · 2017-03-29Clinical Trial Update: Cystic Fibrosis (CF) Leukocyte Genes as Biomarkers for Novel Therapies
A completed clinical trial/update examining leukocyte gene expression as biomarkers to guide development of novel therapies for cystic fibro…
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CLINICAL_TRIALS trial_result · 2017-03-29Clinical Trial Update: Tobramycin Inhalation Powder (TIP) Administered Once Daily Continuously Versus TIP Administered BID in 28 Day on / 28 Day Off Cycles [Phase 4]
This Phase 4 trial compares once-daily continuous Tobramycin Inhalation Powder to twice-daily dosing in cystic fibrosis. The study was termi…
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CLINICAL_TRIALS trial_result · 2017-03-24Clinical Trial Update: IL-17 Neutrophils in CF Lung Inflammation
A completed clinical trial evaluated IL-17 driven neutrophil activity in cystic fibrosis lung inflammation, with results posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-03-23Clinical Trial Update: Treatment of Aspergillus Fumigatus (a Fungal Infection) in Patients With Cystic Fibrosis [Phase 4]
A Phase 4 clinical trial evaluating treatment for Aspergillus fumigatus infection in cystic fibrosis patients has completed, with results po…
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CLINICAL_TRIALS trial_result · 2017-03-22Clinical Trial Update: Non Invasive Ventilation for Acute Exacerbations in Adult CF [NA]
A clinical trial evaluating non-invasive ventilation for acute exacerbations in adults with cystic fibrosis, with unknown status.
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CLINICAL_TRIALS research · 2017-03-14Clinical Trial Update: Puberty in Girls Followed for Cystic Fibrosis
A completed clinical trial related to puberty in girls with cystic fibrosis has been reported. The study follows puberty progression in this…
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CLINICAL_TRIALS trial_result · 2017-03-06Clinical Trial Update: Trial of Doxycycline to Reduce Sputum MMP-9 Activity in Adult Cystic Fibrosis (CF) Patients [NA]
A completed clinical trial studied doxycycline to reduce sputum MMP-9 activity in adults with cystic fibrosis. Results have been posted.
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CLINICAL_TRIALS trial_result · 2017-02-27Clinical Trial Update: Biodistribution of Neutrophile Proteases in the Sputum of Patients Affected by Cystic Fibrosis
A completed clinical trial update examining how neutrophil proteases are distributed in the sputum of patients with cystic fibrosis.
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CLINICAL_TRIALS trial_result · 2017-02-23Clinical Trial Update: Inhaled Molgramostim (rhGM-CSF) in Healthy Adult Subjects [Phase 1]
Phase 1 trial of inhaled molgramostim (rhGM-CSF) in healthy adults has completed, evaluating safety and tolerability for potential pulmonary…
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CLINICAL_TRIALS trial_result · 2017-02-15Clinical Trial Update: Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation [NA]
A completed clinical trial evaluating whether sulforaphane from broccoli sprouts activates the Nrf2 pathway in people with cystic fibrosis; …
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CLINICAL_TRIALS trial_result · 2017-02-15Clinical Trial Update: Nasal Epithelial Cells/Blood Lymphocyte Markers for Cystic Fibrosis (CF)/CF Pulmonary Exacerbations
This completed clinical trial examined nasal epithelial cell and blood lymphocyte biomarkers in cystic fibrosis and CF pulmonary_exacerbatio…
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FDA approval · 2017-02-08FDA Approved: KALYDECO — Supplemental Application (Vertex Pharmaceuticals Incorporated)
The FDA approved a supplemental application for KALYDECO (ivacaftor) from Vertex Pharmaceuticals, resulting in changes to its labeling and/o…
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FDA approval · 2017-02-08FDA Approved: KALYDECO — Supplemental Application (Vertex Pharmaceuticals Incorporated)
FDA approved a supplemental application for KALYDECO (ivacaftor) submitted by Vertex Pharmaceuticals to modify the drug’s labeling, typicall…
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CLINICAL_TRIALS trial_result · 2017-02-01Clinical Trial Update: Roll-Over Study of Ivacaftor in Cystic Fibrosis Pediatric Subjects With a CF Transmembrane Conductance Regulator Gene (CFTR) Gating Mutation [Phase 3]
This is a Phase 3 roll-over study of ivacaftor in pediatric cystic fibrosis patients with CFTR gating mutations, with results posted in 2017…
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CLINICAL_TRIALS trial_result · 2017-01-31Clinical Trial Update: MAD Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Cavosonstat (N91115) in Healthy Subjects (SNO-9) [Phase 1]
A Phase 1 MAD study of Cavosonstat (N91115) to assess safety, tolerability, and pharmacokinetics in healthy subjects has been completed; cys…
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FDA label_change · 2017-01-27FDA Approved: TOBI PODHALER — Supplemental Application (Viatris Specialty LLC)
FDA approved a supplemental application for TOBI Podhaler (tobramycin) submitted by Viatris Specialty LLC.
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CLINICAL_TRIALS research · 2017-01-25Clinical Trial Update: Exercise and Oscillatory Positive Expiratory Pressure Therapy in Cystic Fibrosis [NA]
A clinical trial investigating exercise with oscillatory positive expiratory pressure therapy in cystic fibrosis has completed.
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FDA label_change · 2017-01-11FDA Approved: KALYDECO — Supplemental Application (Vertex Pharmaceuticals Incorporated)
The FDA approved a supplemental application for KALYDECO (ivacaftor) submitted by Vertex, resulting in changes to the drug's labeling.
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CLINICAL_TRIALS trial_result · 2017-01-11Clinical Trial Update: Registry to Monitor the Susceptibility to Aztreonam of Pseudomonas Aeruginosa Isolates From Cystic Fibrosis Patients
A completed registry study monitored the susceptibility of Pseudomonas aeruginosa isolates from cystic fibrosis patients to aztreonam.
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CLINICAL_TRIALS trial_result · 2017-01-10Clinical Trial Update: Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation [Phase 2]
Phase 2 study evaluating Cavosonstat (N91115) in cystic fibrosis patients homozygous for the F508del-CFTR mutation has completed.
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CLINICAL_TRIALS trial_result · 2016-12-30Clinical Trial Update: Elastography of the Liver in Cystic Fibrosis Patients. Diagnostic and Prognostic Aspects [NA]
This completed trial evaluated liver elastography in cystic fibrosis patients to assess its diagnostic and prognostic value for liver involv…
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FDA approval · 2016-12-22FDA Approved: CAYSTON — Supplemental Application (Gilead Sciences, Inc.)
FDA approved a supplemental application for Cayston (aztreonam) from Gilead Sciences, Inc.