Aplastic Anemia
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CLINICAL_TRIALS trial_result · 2025-06-10Clinical Trial Update: Efficacy and Safety of Eltrombopag + CSA in Patients With Moderate Aplastic Anemia (EMAA) [Phase 2, Phase 3]
This update reports on the efficacy and safety of combining eltrombopag with cyclosporine A in patients with moderate aplastic anemia from P…
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CLINICAL_TRIALS research · 2025-06-08Clinical Trial Update: Dose-attenuated IST and Hetrombopag in Elderly (≥65 Years) Patients With Severe Aplastic Anemia [Phase 2]
Phase 2 clinical trial evaluating dose-attenuated immunosuppressive therapy combined with Hetrombopag in elderly patients (65+) with severe …
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CLINICAL_TRIALS research · 2025-06-04Clinical Trial Update: Efficacy and Safety of Sirolimus With or Without Cyclosporin A in Chinese Patients With Aplastic Anemia Refractory/Intolerant to Cyclosporin A [Phase 2]
Phase 2 clinical trial in Chinese patients with aplastic anemia refractory or intolerant to cyclosporin A assessing the efficacy and safety …
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Study on the Short-term Efficacy and Safety of Recombinant Human Thrombopoietin Combined With Immunosuppressant Sequential Eltrombopag Ethanolamine Dry Suspension in the Treatment of SAA/TD-NSAA [Phase 3]
Phase 3 clinical trial evaluating short-term efficacy and safety of combining recombinant human thrombopoietin with sequential eltrombopag e…
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CLINICAL_TRIALS research · 2025-05-28Clinical Trial Update: Real-world Outcomes of Aplastic Anemia Patients Treated With Eltrombopag: A Medical Claims Database Study
This study analyzes real-world outcomes of aplastic anemia patients treated with eltrombopag using a medical claims database.
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CLINICAL_TRIALS trial_result · 2025-05-11Clinical Trial Update: Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia [NA]
This clinical trial has completed and reports results comparing unrelated donor transplant versus immune therapy in pediatric severe aplasti…
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CLINICAL_TRIALS research · 2025-05-11Clinical Trial Update: Treatment of Transfusion-dependent Nonsevere Aplastic Anemia With Luspatercept: a Multicenter Prospective Clinical Study [NA]
A multicenter prospective trial evaluating luspatercept for transfusion-dependent non-severe aplastic anemia is currently not recruiting.
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CLINICAL_TRIALS trial_result · 2025-05-08Clinical Trial Update: Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia [NA]
A completed clinical trial investigating hematopoietic stem cell transplantation for Dyskeratosis Congenita or Severe Aplastic Anemia has po…
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CLINICAL_TRIALS trial_result · 2025-04-30Clinical Trial Update: CsA+ATG+AVA vs. CsA+AVA for the Treatment of Newly-diagnosed SAA in the Elderly [Phase 4]
A Phase 4 trial comparing CsA+ATG+AVA versus CsA+AVA in elderly patients with newly diagnosed aplastic anemia has been completed.
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CLINICAL_TRIALS trial_result · 2025-03-20Clinical Trial Update: Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies [Phase 2]
This Phase 2 trial investigates reduced-intensity chemotherapy and radiation therapy before donor stem cell transplantation for various hema…
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CLINICAL_TRIALS trial_result · 2025-03-04Clinical Trial Update: A Phase II Dose-escalation Study Characterizing the PK of Eltrombopag in Pediatric Patients With Previously Untreated or Relapsed Severe Aplastic Anemia or Recurrent Aplastic Anemia [Phase 2]
A Phase II dose-escalation study evaluated the pharmacokinetics of eltrombopag in pediatric patients with previously untreated or relapsed/r…
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CLINICAL_TRIALS trial_result · 2025-02-18Clinical Trial Update: Study of CM313(SC) Injection in Subjects With Relapsed/Refractory Aplastic Anemia [Phase 1, Phase 2]
This clinical trial update concerns CM313 for relapsed/refractory aplastic anemia, a subcutaneous injection studied in Phase 1/2; the study …
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Study Assessed the Safety and Efficacy of Eltrombopag in Chinese Refractory or Relapsed Severe Aplastic Anemia (SAA) Subjects. [Phase 2]
A Phase 2 study evaluated the safety and efficacy of eltrombopag in Chinese patients with refractory or relapsed severe aplastic anemia.
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FDA approval · 2025-01-17FDA Approved: ELTROMBOPAG — Original Application (XLCare Pharmaceuticals Inc.)
FDA approves a generic eltrombopag product under an original application (ANDA 206788) submitted by XLCare Pharmaceuticals Inc.
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CLINICAL_TRIALS research · 2025-01-10Clinical Trial Update: Reduced-dose Conditioning Regimen Containing TBI in HSCT Treating Elderly Patients With Aplastic Anemia [Phase 2]
Phase 2 trial assessing a reduced-dose conditioning regimen that includes total body irradiation (TBI) for hematopoietic stem cell transplan…
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CLINICAL_TRIALS trial_result · 2025-01-03Clinical Trial Update: Efficacy of Daratumumab to Overcome Platelet Transfusion Refractoriness in Patients with Aplastic Anemia [Phase 1]
Phase 1 trial evaluating daratumumab to overcome platelet transfusion refractoriness in patients with aplastic anemia.
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CLINICAL_TRIALS trial_result · 2024-12-20Clinical Trial Update: Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients [Phase 2]
Phase 2 trial evaluating posaconazole prophylaxis during ATG treatment in patients with aplastic anemia or myelodysplastic syndromes; the st…
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Standard Immunosuppressive Therapy Combined With Romiplostim N01 as First-line Treatment for Severe Aplastic Anemia [Phase 2]
A phase 2 clinical trial investigates using standard immunosuppressive therapy with Romiplostim as a first-line treatment for severe aplasti…
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CLINICAL_TRIALS research · 2024-11-19Clinical Trial Update: Reduced Dose of Cyclophosphamide Combined With Standard Immunosuppressive Therapy to Treat Severe Aplastic Anemia [Phase 2]
A Phase 2 clinical trial is evaluating a reduced-dose cyclophosphamide regimen combined with standard immunosuppressive therapy for severe a…
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CLINICAL_TRIALS trial_result · 2024-11-07Clinical Trial Update: Hetrombopag or Placebo in Treatment-Naive Severe Aplastic Anemia [Phase 3]
A Phase 3 trial evaluating hetrombopag versus placebo in treatment-naive severe aplastic anemia has completed.
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CLINICAL_TRIALS trial_result · 2024-11-01Clinical Trial Update: Effectiveness of Early Intervention in Transfusion Independent Aplastic Anemia: a Retrospective Medical Claims Database Study
This retrospective medical claims study evaluates whether early intervention improves outcomes in transfusion-independent aplastic anemia.
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CLINICAL_TRIALS research · 2024-10-17Clinical Trial Update: Indication of HSCT in Patients With Refractory/Relapse AA After First-line Standard Immunosuppressive Therapy Aged More Than 40 Years [Phase 2]
This Phase 2 clinical trial update discusses using hematopoietic stem cell transplantation for patients with refractory or relapsed aplastic…
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CLINICAL_TRIALS research · 2024-10-09Clinical Trial Update: CD7 CAR-T Bridging to alloHSCT for Severe Aplastic Anemia [EARLY_Phase 1]
Early-phase 1 clinical trial update announcing recruitment for CD7 CAR-T cells as a bridge to allogeneic stem cell transplantation in severe…
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CLINICAL_TRIALS trial_result · 2024-09-25Clinical Trial Update: Cyclophosphamide Added to Standard Immunosuppressive Therapy With Herombopag as Front-line Therapy in Patients With Severe Aplastic Anemia [Phase 2]
Phase 2 clinical trial assessing adding cyclophosphamide to standard immunosuppressive therapy with herombopag as front-line treatment for s…
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CLINICAL_TRIALS research · 2024-09-23Clinical Trial Update: REscuing Bone Marrow Function in Patients with AplaStic AnaEmia and Bone Marrow FaiLure Post AllogEneiC Transplantation 2 [Phase 1, Phase 2]
A Phase 1/2 clinical trial in Melbourne Health is investigating rescue of bone marrow function in patients with aplastic anemia and bone mar…