Aplastic Anemia
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Extension Study of Hetrombopag in Severe Aplastic Anemia [Phase 3]
Update on a Phase 3 extension study of hetrombopag for treatment-naive severe aplastic anemia; the study is currently active but not recruit…
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CLINICAL_TRIALS research · 2024-08-21Clinical Trial Update: Feasibility Study to Assess an Adapted Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Transplantation [NA]
This ClinicalTrials.gov update reports a completed feasibility study evaluating an adapted physical activity program for children, adolescen…
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CLINICAL_TRIALS research · 2024-08-02Clinical Trial Update: A Study of Romiplostim for the Treatment of Refractory Transfusion-dependent NSAA [Phase 4]
Phase 4 clinical trial evaluating romiplostim for refractory transfusion-dependent aplastic anemia; currently not yet recruiting.
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CLINICAL_TRIALS trial_result · 2024-07-30Clinical Trial Update: TPO-Mimetic Use in Children for Hematopoietic Failure [EARLY_Phase 1]
An early-phase 1 pediatric trial evaluating thrombopoietin mimetics for hematopoietic failure has completed. The study enrolled children wit…
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CLINICAL_TRIALS other · 2024-07-29Clinical Trial Update: Efficacy and Safety of rhTPO in Combination With Cyclosporine Versus Cyclosporine Alone in the Treatment of TD-NSAA [Phase 4]
This is a Phase 4 clinical trial update comparing rhTPO plus cyclosporine versus cyclosporine alone in transfusion-dependent aplastic anemia…
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CLINICAL_TRIALS research · 2024-07-24Clinical Trial Update: NAC for Hematopoietic Recovery in SAA [Phase 2]
Phase 2 clinical trial evaluating N-acetylcysteine for hematopoietic recovery in aplastic anemia; sponsored by Peking University People's Ho…
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CLINICAL_TRIALS research · 2024-07-24Clinical Trial Update: Ropustin for Refractory Aplastic Anaemia After Radiotherapy - a Single-centre, Prospective, Open-label, Single-arm Study [Phase 4]
A Phase 4, single-centre, open-label, single-arm trial evaluating Ropustin for refractory aplastic anemia after radiotherapy; currently not …
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CLINICAL_TRIALS trial_result · 2024-07-16Clinical Trial Update: Study of Romiplostim(AMG531) in Subjects With Aplastic Anemia [Phase 2, Phase 3]
Romiplostim (AMG531) is being studied in Phase 2 and Phase 3 trials for aplastic anemia, and the trial is reported as completed.
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CLINICAL_TRIALS research · 2024-05-23Clinical Trial Update: A Prospective Study on the Treatment of Recurrent/Refractory/Intolerable NSAA With Lusutrombopag [Phase 4]
This is a Phase 4 prospective study evaluating lusutrombopag for aplastic anemia, with status NOT_YET_RECRUITING.
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CLINICAL_TRIALS research · 2024-05-22Clinical Trial Update: Luspatercept Plus CsA vs CsA for the Treatment of Newly Diagnosed Non-Transfusion-Dependent NSAA [Phase 4]
This clinical trial update describes a Phase 4 study comparing luspatercept plus cyclosporine vs cyclosporine alone for newly diagnosed non-…
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FDA approval · 2024-04-18FDA Approved: ELTROMBOPAG — Original Application (Camber Pharmaceuticals, Inc.)
FDA approved Camber Pharmaceuticals' original application for a generic eltrombopag (eltrombopag olamine).
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CLINICAL_TRIALS trial_result · 2024-03-21Clinical Trial Update: Sirolimus+Abatacept+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to Calcineurin Inhibitors [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating a combination of sirolimus, abatacept, and mycophenolate mofetil to prevent aGraft-versus-Host Disease…
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CLINICAL_TRIALS trial_result · 2024-02-12Clinical Trial Update: Efficacy and Safety of Avatrombopag vs. Avatrombopag Combined With rhTPO in the Treatment of SAA [Phase 2]
Phase 2 trial comparing avatrombopag alone versus avatrombopag with rhTPO for anemia due to aplastic anemia, focusing on efficacy and safety…
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CLINICAL_TRIALS trial_result · 2023-12-11Clinical Trial Update: Eltrombopag Combined With Cyclosporine as First Line Therapy in Patients With Severe Acquired Aplastic Anemia [Phase 2]
A Phase 2 trial evaluating eltrombopag combined with cyclosporine as first-line therapy in adults with severe acquired aplastic anemia has c…
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CLINICAL_TRIALS trial_result · 2023-12-08Clinical Trial Update: Efficacy and Safety of CsA+AVA in the Treatment of NSAA in the Elderly [Phase 2]
Phase 2 trial update on the combination of CsA and AVA for aplastic anemia in elderly patients, focusing on efficacy and safety.
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FDA approval · 2023-11-29FDA Approved: ALVAIZ — Original Application (Teva Pharmaceuticals, Inc.)
ALVAIZ (eltrombopag) from Teva received FDA approval through an original application for the treatment of thrombocytopenia conditions by inc…
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CLINICAL_TRIALS trial_result · 2023-11-18Clinical Trial Update: The Optimization of Conditioning Regimen for HLA Matched HSCT in SAA [Phase 4]
Phase 4 clinical trial update focusing on optimizing conditioning regimens for HLA-matched hematopoietic stem cell transplantation in severe…
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CLINICAL_TRIALS trial_result · 2023-09-26Clinical Trial Update: Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study [Phase 1, Phase 2]
Long-term follow-up update from BP-004 study (Phase 1/Phase 2) by Bellicum Pharmaceuticals; study status TERMINATED with results posted in 2…
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CLINICAL_TRIALS trial_result · 2023-08-31Clinical Trial Update: Nandrolone Decanoate in the Treatment of Telomeropathies [Phase 1, Phase 2]
Phase 1/2 clinical trial of nandrolone decanoate for telomeropathies, including aplastic anemia and bone marrow failure syndromes, has compl…
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CLINICAL_TRIALS trial_result · 2023-08-24Clinical Trial Update: Efficacy of IST Combined With TPO-RA in the Treatment of AA and Establishment of a Recurrence Prediction System [Phase 4]
Phase 4 clinical trial update evaluating efficacy of IST in combination with a TPO-RA for aplastic anemia and development of a recurrence pr…
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CLINICAL_TRIALS trial_result · 2023-08-22Clinical Trial Update: A Prospective, Randomized, Controlled Study of rhTPO in Combination With Herombopag + CsA vs Herombopag + CsA for the Treatment of Primary TD-NSAA [Phase 4]
A Phase 4 randomized trial evaluating rhTPO with Herombopag and CsA versus Herombopag and CsA for primary TD-NSAA in aplastic anemia; curren…
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CLINICAL_TRIALS trial_result · 2023-03-17Clinical Trial Update: The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia [Phase 4]
Phase 4 trial assessing immunosuppressive therapy combined with cord blood transfusion for severe aplastic anemia completed.
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FDA approval · 2023-03-16FDA Approved: DEFERASIROX — Supplemental Application (Camber Pharmaceuticals, Inc.)
FDA approved a supplemental application for Deferasirox from Camber Pharmaceuticals, authorizing a generic product under ANDA 216229.
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CLINICAL_TRIALS trial_result · 2023-03-10Clinical Trial Update: Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia [Phase 2]
Phase 2 trial update on transplantation of partially mismatched related or matched unrelated bone marrow for refractory severe aplastic anem…
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CLINICAL_TRIALS trial_result · 2023-02-09Clinical Trial Update: Avatrombopag Combined With IST as First-line Treatment for SAA [Phase 2]
Phase 2 clinical trial update exploring avatrombopag plus IST as first-line therapy for severe aplastic anemia.