Apical Periodontitis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-08-15Clinical Trial Update: Effect of Common Analgesia on Pulp Sensibility [NA]
A completed clinical trial evaluating the effect of a common analgesic on pulp sensibility in irreversible pulpitis with apical periodontiti…
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: Evaluation of Different Root Canal Obturation Techniques [NA]
A completed clinical trial evaluating different root canal obturation techniques for apical periodontitis and periapical lesion.
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: Evaluation of Different Root Canal Irrigation Techniques [NA]
Medipol University sponsored a study evaluating different root canal irrigation techniques for apical periodontitis. The trial status is com…
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp [EARLY_Phase 1]
ClinicalTrials.gov notes an early Phase 1 study comparing Bio-C Temp with calcium hydroxide as intracanal dressings in patients with necroti…
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits [NA]
A clinical trial evaluating pain and MMP-9 expression after root canal instrumentation of necrotic pulps with apical periodontitis, comparin…
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CLINICAL_TRIALS trial_result · 2025-07-25Clinical Trial Update: Healing Outcomes Following Hydraulic Condensation With a Bioactive Bioceramic Sealer in Root Canal Treatment [NA]
This completed clinical trial evaluated healing outcomes after hydraulic condensation with a bioactive bioceramic sealer in root canal treat…
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CLINICAL_TRIALS trial_result · 2025-07-24Clinical Trial Update: Bite Force Measurements
Rutgers, The State University of New Jersey reports a clinical trial update on bite force measurements, with recruitment ongoing for irrever…
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CLINICAL_TRIALS research · 2025-07-17Clinical Trial Update: Sonic vs Passive Ultrasonic Irrigation for Chronic Apical Periodontitis [NA]
A clinical trial comparing Sonic irrigation with Passive Ultrasonic Irrigation for Chronic Apical Periodontitis is currently recruiting at N…
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: Effect of Different Root Canal Sealers on Oxidative Stress Markers [NA]
A clinical trial is evaluating whether different root canal sealers influence oxidative stress markers in people with chronic apical periodo…
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CLINICAL_TRIALS trial_result · 2025-07-09Clinical Trial Update: Evaluation of Post-Operative Pain Following the Use of Nano-Calcium Hydroxide [NA]
A completed clinical trial from Cukurova University evaluating post-operative pain after using Nano-Calcium Hydroxide for chronic apical per…
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial) [NA]
A clinical trial evaluating chitosan irrigation in premolar root canal therapy is currently recruiting patients with apical periodontitis, d…
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CLINICAL_TRIALS trial_result · 2025-06-27Clinical Trial Update: The Effect of Different Sodium Hypochlorite Concentrations and Activation Techniques on Postoperative Pain [NA]
The trial evaluated the effect of different sodium hypochlorite concentrations and activation techniques on postoperative pain in chronic ap…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods [NA]
Clinical trial update on antibacterial efficacy of root canal irrigation methods; currently enrolling by invitation for conditions including…
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Effect of Use of Calcium Hydroxide and Metformin Intracanal Medicament After NSRCT [Phase 2, Phase 3]
A Phase 2/Phase 3 trial evaluating calcium hydroxide and metformin as intracanal medicaments after non-surgical root canal therapy for apica…
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CLINICAL_TRIALS research · 2025-05-11Clinical Trial Update: Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal [NA]
This ClinicalTrials.gov entry outlines an ongoing clinical investigation from the National and Kapodistrian University of Athens evaluating …
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CLINICAL_TRIALS research · 2025-04-17Clinical Trial Update: Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing [NA]
A completed study evaluating photodynamic therapy as an adjunct to root canal treatment in patients with type 2 diabetes, including microbio…
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CLINICAL_TRIALS trial_result · 2025-03-20Clinical Trial Update: Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial [NA]
This completed randomized controlled trial compares periapical bleeding versus platelet-rich fibrin (PRF) techniques in regenerative endodon…
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CLINICAL_TRIALS research · 2025-03-05Clinical Trial Update: Effect of Different Sealers and Activation Methods on Pain [Phase 4]
This clinical trial update describes a Phase 4 study evaluating how different sealer types and activation methods affect pain in chronic api…
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CLINICAL_TRIALS trial_result · 2025-03-04Clinical Trial Update: The Role of Root Canal Treatment in Alleviating Endodontic Pain-Induced Asymmetry and Restoring Muscle Balance
A completed clinical trial evaluated whether root canal treatment reduces endodontic pain–induced asymmetry and helps restore jaw muscle bal…
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CLINICAL_TRIALS trial_result · 2025-02-25Clinical Trial Update: Lesion Healing After Regenerative Endodontic Treatment [NA]
A completed clinical trial evaluating lesion healing after regenerative endodontic treatment for apical periodontitis at TC Erciyes Universi…
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CLINICAL_TRIALS trial_result · 2025-02-20Clinical Trial Update: Chlorhexidine Versus N-Asetil Sistein Irrigation in Mandibular Molar Teeth with Chronic Apical Periodontitis [NA]
A completed clinical trial comparing chlorhexidine irrigation to N-acetylcysteine irrigation in mandibular molars with chronic apical period…
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CLINICAL_TRIALS research · 2025-02-12Clinical Trial Update: To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and Triple Antibiotic Paste in Teeth with Single Roots and Periapical Disease Called Apical Periodontitis [Phase 2, Phase 3]
A Phase 2/3 trial is comparing calcium hydroxide and triple antibiotic paste as intra-canal medicaments for teeth with single roots and apic…
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CLINICAL_TRIALS trial_result · 2025-01-13Clinical Trial Update: Postoperative Pain and Periapical Tissue Healing [NA]
A completed clinical trial update focusing on postoperative pain and healing of periapical tissue in cases of necrotic mandibular molars.
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CLINICAL_TRIALS research · 2025-01-08Clinical Trial Update: The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study [Phase 1, Phase 2]
This clinical trial update describes a randomized controlled study evaluating human umbilical cord mesenchymal stem cells and exosomes for h…
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CLINICAL_TRIALS research · 2024-12-16Clinical Trial Update: One Vs Two Visits Root Canal Treatments in Infected Teeth [NA]
A Malmö University trial compares one-visit versus two-visit root canal treatment in teeth with apical periodontitis and dental pulp necrosi…