Apical Periodontitis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Vital Pulp Therapy Versus Root Canal Treatment for Irreversible Pulpitis With Incipient Apical Periodontitis Diagnosed Using Artificial Intelligence This Keeps: the Main Intervention (Vital Pulp Therapy) the Comparison (Root Canal Treatment) the Condition (Irreversible Pulpitis With Incipient Apic [NA]
A clinical trial at Ain Shams University comparing vital pulp therapy to root canal treatment for symptomatic irreversible pulpitis with inc…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: The Aim of This Study is to Evaluate the Relationship Between Genetic Polymorphisms and Periapical Lesion Healing in Individuals With Chronic Apical Periodontitis at Clinical and Radiological Levels.
A clinical trial update describing a study to evaluate the relationship between genetic polymorphisms and healing of periapical lesions in c…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis [NA]
A clinical trial evaluating the effectiveness of oleanolic acid as an intracanal medicament to reduce infection and inflammation in apical p…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: In Vivo Study on the Material Properties of iRoot SP and nRoot SP Root Canal Sealers [NA]
An in vivo study is being conducted to evaluate the material properties of iRoot SP and nRoot SP root canal sealers for chronic apical perio…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: The Effect of Anti-inflammatory Cryoagent on the Level of Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis and Apical Periodontitis. [Phase 2]
Phase 2 clinical trial assessing the anti-inflammatory Cryoagent for reducing postoperative pain in patients with symptomatic irreversible p…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: MMP-2/3 and Periapical Healing Outcomes
A clinical trial update from TC Erciyes University examines the involvement of MMP-2/3 in chronic apical periodontitis and periapical healin…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Nanozymes in Endodontics [Phase 4]
A Phase 4 trial update on nanozyme-based therapy for endodontic diseases. The study is not yet recruiting.
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Biomarkers in Apical Periodontitis
A clinical trial update from Kırıkkale University studies biomarkers and cytokines in apical periodontitis with retreatment, and is currentl…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment [NA]
A clinical trial evaluating the effectiveness of i-PRF as a revitalization approach in non-surgical root canal retreatment, currently recrui…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France
A France-based clinical trial evaluating professional practices among dental surgeons for treating non-vital primary teeth, including cases …
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Interleukin 8 and10 Levels Changes in Teeth With Necrotic Pulp and Apical Periodontitis [NA]
A completed clinical trial evaluating changes in interleukin-8 and interleukin-10 levels in teeth with necrotic pulp and apical periodontiti…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: INVESTIGATION OF THE EFFECT OF DIFFERENT ACTIVATION TECHNIQUES ON TLR9, IL6, IL10, TNF-ALFA LEVELS IN HEALTHY AND TYPE 2 DIABETIC PATIENTS WITH APICAL PERIODONTITIS REQUIRING RETREATMENT
Sponsored clinical trial to assess how different activation techniques affect inflammatory biomarkers (TLR9, IL-6, IL-10, TNF-alpha) in heal…
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: Effect of Different Chelation Protocols on the Healing of Periapical Lesions in Teeth With Chronic Apical Periodontitis [NA]
The document describes a clinical trial evaluating how different chelation protocols affect the healing of periapical lesions in teeth with …
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Endodontic Microsurgery [Phase 4]
A Phase 4 clinical trial update for endodontic microsurgery addressing apical periodontitis; the study is not yet recruiting.
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Clinical Efficacy of AH Plus Bioceramic Sealer [NA]
A Kuwait Ministry of Health-sponsored clinical trial is evaluating the efficacy of AH Plus Bioceramic Sealer for treating root canal infecti…
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CLINICAL_TRIALS research · 2026-01-06Clinical Trial Update: Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth. [Phase 3]
A Phase 3 clinical trial comparing garlic gel to calcium hydroxide as an intracanal medicament in nonsurgical root canal treatment; currentl…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Neurokinin A and Matrix Metalloproteinase 9 Levels in Gingival Crevicular Fluid Samples of Teeth With Symptomatic Irreversible Pulpitis With Symptomatic Apical Periodontitis
This clinical trial entry describes a study measuring neurokinin A and matrix metalloproteinase-9 levels in gingival crevicular fluid from t…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: The Present Study Aims to Follow up on All Root Canal Treatments Performed During the Year 2023 Within the Public Dental Services of the Counties of Jönköping, Kalmar, and Östergötland, Sweden. The Study is Entirely Observational in Nature.
An observational study in Sweden will follow up all root canal treatments performed in 2023 within public dental services in Jönköping, Kalm…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: A Comparative Analysis of Biomaterials for Retrograde Filling in Apical Surgery. [NA]
This Clinical Trial Update reports a comparative analysis of biomaterials for retrograde filling in apical surgery to treat apical periodont…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: The Efficiency of 810 nm Diode Laser on Periapical Healing After Root Canal Retreatment [NA]
Clinical trial evaluating 810 nm diode laser disinfection to improve periapical healing after root canal retreatment is currently recruiting…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth [NA]
This clinical trial update concerns using platelet-rich fibrin in regenerative endodontic treatment for mature permanent teeth, sponsored by…
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: Effect of Ozone Use in Intracanal Irrigation on Oxidative Stress Level in Teeth With Asymptomatic Apical Periodontitis [NA]
This clinical trial update describes an ongoing study evaluating the effect of ozone-based intracanal irrigation on oxidative stress in teet…
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: To Evaluate Periapical Healing Post Full Pulpotomy in Teeth With and Without Apical Periodontitis [NA]
This clinical trial evaluates periapical healing after full pulpotomy in teeth with and without apical periodontitis. The study status is NO…
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CLINICAL_TRIALS research · 2025-08-27Clinical Trial Update: Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
This clinical trial from the University of Pennsylvania evaluates periapical healing after endodontic microsurgery using leukocyte- and plat…
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp [EARLY_Phase 1]
ClinicalTrials.gov notes an early Phase 1 study comparing Bio-C Temp with calcium hydroxide as intracanal dressings in patients with necroti…