Amyotrophic Lateral Sclerosis
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CLINICAL_TRIALS trial_result · 2025-05-16Clinical Trial Update: Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit [NA]
A completed clinical trial update on the Optimizing BCI-FIT toolkit (Brain Computer Interface - Functional Implementation Toolkit) sponsored…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease [NA]
A completed clinical trial evaluating acute intermittent hypoxia and breathing in amyotrophic lateral sclerosis and other neuromuscular dise…
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CLINICAL_TRIALS trial_result · 2025-05-06Clinical Trial Update: Safety of Engensis in Participants With Amyotrophic Lateral Sclerosis [Phase 2]
Phase 2 safety update for Engensis (VM202) in participants with amyotrophic lateral sclerosis. Results have been posted.
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CLINICAL_TRIALS trial_result · 2025-05-01Clinical Trial Update: TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating TJ-68 in amyotrophic lateral sclerosis and muscle cramps has completed and posted results.
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CLINICAL_TRIALS trial_result · 2025-04-24Clinical Trial Update: Safety and Tolerance of RAG-17 in Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation [EARLY_Phase 1]
Early-phase results describe the safety and tolerability of RAG-17 in amyotrophic lateral sclerosis patients with SOD1 gene mutation.
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CLINICAL_TRIALS trial_result · 2025-04-24Clinical Trial Update: MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
The Phase 2 Meridian trial evaluating pegcetacoplan in adults with amyotrophic lateral sclerosis was terminated; results have been posted.
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CLINICAL_TRIALS trial_result · 2025-04-20Clinical Trial Update: Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
Phase 2 trial evaluating tolerability and efficacy of L-Serine in patients with amyotrophic lateral sclerosis; the study was terminated and …
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CLINICAL_TRIALS trial_result · 2025-04-17Clinical Trial Update: Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intrathecal Injection for ALS [Phase 1]
Phase 1 clinical trial update evaluating the safety of intrathecal infusion of cultured allogeneic umbilical cord-derived mesenchymal stem c…
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CLINICAL_TRIALS trial_result · 2025-04-13Clinical Trial Update: Exploratory Evaluation of [11C]MPC6827 [EARLY_Phase 1]
An exploratory early Phase 1 study of the PET tracer [11C]MPC6827 conducted by Columbia University, reporting initial safety/imaging finding…
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CLINICAL_TRIALS trial_result · 2025-04-08Clinical Trial Update: Effects of L-Carnitine in Amyotrophic Lateral Sclerosis Patients With CHCHD10 Mutations [Phase 4]
Phase 4 clinical trial evaluating the effects of L-Carnitine in ALS patients with CHCHD10 mutations has completed.
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CLINICAL_TRIALS trial_result · 2025-04-02Clinical Trial Update: Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
Phase 2 clinical trial evaluating intrathecal autologous adipose-derived mesenchymal stromal cells for ALS has posted results; the trial is …
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CLINICAL_TRIALS trial_result · 2025-03-27Clinical Trial Update: Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS [Phase 3]
A Phase 3 clinical trial evaluating the efficacy and safety of oral edaravone in amyotrophic lateral sclerosis has been terminated, with res…
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CLINICAL_TRIALS trial_result · 2025-03-27Clinical Trial Update: Efficacy and Safety Extension Study of Oral Edaravone Administered in Subjects With ALS [Phase 3]
Termination of a Phase 3 extension study of oral edaravone in amyotrophic lateral sclerosis has been announced. Results have been posted.
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CLINICAL_TRIALS trial_result · 2025-03-26Clinical Trial Update: Clinical Trial of Ultra-high Dose Methylcobalamin for ALS [Phase 3]
Phase 3 trial of ultra-high dose methylcobalamin for amyotrophic lateral sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2025-03-25Clinical Trial Update: Early Feasibility Study of the MyoRegulator® for Treatment of ALS [NA]
The early feasibility study of the MyoRegulator for amyotrophic lateral sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2025-03-21Clinical Trial Update: Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
A Phase 2 study of SAR443820 in amyotrophic lateral sclerosis was terminated, and the trial results have been posted.
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CLINICAL_TRIALS trial_result · 2025-03-19Clinical Trial Update: Study of Safety and Proof of the Mechanism of BLZ945 in ALS Patients [Phase 2]
Novartis' Phase 2 trial of the CSF-1R pathway inhibitor BLZ945 in amyotrophic lateral sclerosis was terminated, with trial results posted on…
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CLINICAL_TRIALS trial_result · 2025-03-18Clinical Trial Update: Study to Investigate the Efficacy and Safety of FAB122 (Daily Oral Edaravone) in Patients With Amyotrophic Lateral Sclerosis [Phase 3]
Phase 3 trial results for FAB122, a daily oral edaravone formulation, in amyotrophic lateral sclerosis have been posted.
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CLINICAL_TRIALS trial_result · 2025-03-04Clinical Trial Update: Study to Investigate the Long-term Safety of FAB122 in Patients With Amyotrophic Lateral Sclerosis [Phase 3]
A Phase 3 study evaluating the long-term safety of FAB122 in amyotrophic lateral sclerosis was terminated, and the results have been posted.
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CLINICAL_TRIALS trial_result · 2025-02-04Clinical Trial Update: Salivary Biomarker Discovery by Raman Spectroscopy in ALS (SalivALS)
A completed clinical trial investigating salivary biomarkers for amyotrophic lateral sclerosis using Raman spectroscopy (SalivALS), sponsore…
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Extension Study Following the Studies MT-1186-A03 or A04 to Evaluate the Safety of Oral Edaravone in Subjects With ALS [Phase 3]
Extension Phase 3 study evaluating the safety of oral edaravone in subjects with amyotrophic lateral sclerosis. Results were posted on 2025-…
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CLINICAL_TRIALS trial_result · 2025-01-28Clinical Trial Update: Tideglusib for the Treatment of Amyotrophic Lateral Sclerosis [Phase 2]
Phase 2 clinical trial update for Tideglusib in amyotrophic lateral sclerosis; the study is not yet recruiting.
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CLINICAL_TRIALS trial_result · 2025-01-15Clinical Trial Update: A First in Human Study of ORT247 in Healthy Volunteers [Phase 1]
First-in-human Phase 1 trial of ORT247 in healthy volunteers has completed, evaluating initial safety, tolerability, and pharmacokinetics.
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CLINICAL_TRIALS trial_result · 2025-01-13Clinical Trial Update: Extension Study Evaluating The Safety And Tolerability of AMX0035 [Phase 3]
This document reports the completion of a Phase 3 extension study evaluating the safety and tolerability of AMX0035 in amyotrophic lateral s…
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CLINICAL_TRIALS trial_result · 2025-01-10Clinical Trial Update: Evaluation the Efficacy and Safety of Mutiple Lenzumestrocel (Neuronata-R® Inj.) Treatment in Patients with ALS [Phase 3]
Phase 3 clinical trial evaluating the efficacy and safety of multiple Lenzumestrocel (Neuronata-R) injections in patients with amyotrophic l…