Amyotrophic Lateral Sclerosis
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CLINICAL_TRIALS trial_result · 2025-09-05Clinical Trial Update: A Phase IIb, Multi-Center, Multinational, Double-Blind, Placebo-Controlled Study, With an Open Label Extension, to Evaluate Safety, Tolerability and Efficacy of PrimeC in Subjects With ALS [Phase 2]
Phase IIb multicenter, multinational trial of PrimeC in amyotrophic lateral sclerosis has completed and evaluated safety, tolerability and e…
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: A Study Exploring the PK/PD Relationship of QRL-101 in Adults With ALS [Phase 1]
This update reports the completion of a Phase 1 study evaluating the pharmacokinetic and pharmacodynamic relationship of QRL-101 in adults w…
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CLINICAL_TRIALS trial_result · 2025-08-29Clinical Trial Update: Long-Term Evaluation of BIIB067 (Tofersen) [Phase 3]
Long-term evaluation results for tofersen (BIIB067) in amyotrophic lateral sclerosis due to SOD1 mutation have been posted from a Phase 3 tr…
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CLINICAL_TRIALS trial_result · 2025-08-29Clinical Trial Update: A Study Evaluating the Safety and Tolerability of QRL-201 in ALS [Phase 1]
This Phase 1 trial assesses the safety and tolerability of QRL-201 in amyotrophic lateral sclerosis. It is currently active but not recruiti…
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CLINICAL_TRIALS trial_result · 2025-08-22Clinical Trial Update: Patients With ALS and Other Motor Disorders Will be Treated With Mesenchymal Cell Exosome Solution [Phase 1]
This clinical trial update reports the completion of a Phase 1 study evaluating a Mesenchymal Cell Exosome Solution in patients with amyotro…
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CLINICAL_TRIALS trial_result · 2025-08-20Clinical Trial Update: Study of AMDX-2011P as a Retinal Tracer in Subjects With Neurodegenerative Diseases Associated With Amyloidogenic Proteinopathy [Phase 1, Phase 2]
Phase 1/2 study of AMDX-2011P as a retinal tracer in Parkinson's disease and Amyotrophic Lateral Sclerosis has completed enrollment. Results…
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CLINICAL_TRIALS trial_result · 2025-08-20Clinical Trial Update: Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone Disease [Phase 1]
Phase 1 dose-escalation study evaluating safety, tolerability and pharmacokinetics of IC14 in motor neuron disease/ALS; the trial has comple…
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CLINICAL_TRIALS trial_result · 2025-08-19Clinical Trial Update: A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in Participants With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
The update notes the completion of a Phase 2 study evaluating AP-101 in amyotrophic lateral sclerosis, assessing safety, tolerability, pharm…
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CLINICAL_TRIALS trial_result · 2025-08-13Clinical Trial Update: Open Label Extension Study of AMX0035 in Patients With ALS [Phase 2]
An open-label extension study of AMX0035 in Amyotrophic Lateral Sclerosis (ALS) completed Phase 2, with results from the extension reported.
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CLINICAL_TRIALS trial_result · 2025-08-08Clinical Trial Update: Yogic Breathing Exercise for People With Amyotrophic Lateral Sclerosis [NA]
A clinical trial evaluating a yogic breathing exercise for people with amyotrophic lateral sclerosis (and myasthenia gravis) has completed.
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Remotely Supervised tDCS for Slowing ALS Disease Progression [NA]
A completed clinical trial evaluated remotely supervised transcranial direct current stimulation (tDCS) to slow progression in amyotrophic l…
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALS [Phase 2]
A Phase 2 study of PTC857 in amyotrophic lateral sclerosis was terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: A Phase 1 Study to Investigate the Safety and Pharmacokinetics of Fosigotifator in Patients With Amyotrophic Lateral Sclerosis [Phase 1]
A Phase 1 study evaluating the safety and pharmacokinetics of Fosigotifator in patients with Amyotrophic Lateral Sclerosis has been terminat…
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CLINICAL_TRIALS trial_result · 2025-07-11Clinical Trial Update: Triumeq in Amyotrophic Lateral Sclerosis [Phase 3]
A Phase 3 trial of Triumeq for amyotrophic lateral sclerosis has been terminated.
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CLINICAL_TRIALS trial_result · 2025-07-01Clinical Trial Update: RT001 in Amyotrophic Lateral Sclerosis [Phase 2]
The Phase 2 clinical trial of RT001 for amyotrophic lateral sclerosis has completed. The study is sponsored by Biojiva LLC.
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CLINICAL_TRIALS trial_result · 2025-06-29Clinical Trial Update: Study of SPG302 in Healthy Volunteers and ALS Participants [Phase 1]
Phase 1 trial of SPG302 in healthy volunteers and ALS participants has completed.
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CLINICAL_TRIALS trial_result · 2025-06-26Clinical Trial Update: A Safety and Tolerability Study of ILB® in Patients With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
Phase 2 safety and tolerability study of ILB in patients with amyotrophic lateral sclerosis has been terminated; results have been posted.
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CLINICAL_TRIALS trial_result · 2025-06-22Clinical Trial Update: Study of Safety, Tolerability, and Biological Activity of LAM-002A in C9ORF72-Associated Amyotrophic Lateral Sclerosis [Phase 2]
Phase 2 study evaluating LAM-002A in C9orf72-associated amyotrophic lateral sclerosis has completed, assessing safety, tolerability, and bio…
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: A Phase 2 Study to Evaluate AL001 in C9orf72-Associated ALS [Phase 2]
A Phase 2 trial evaluating AL001 in C9orf72-associated amyotrophic lateral sclerosis has been terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2025-06-15Clinical Trial Update: Safety and Gut Microbiota Analysis of an Oral Microbiotherapy in Patients With Amyotrophic Lateral Sclerosis [Phase 1]
Phase 1 trial evaluating the safety and gut microbiota effects of an oral microbiotherapy in patients with amyotrophic lateral sclerosis has…
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CLINICAL_TRIALS trial_result · 2025-06-11Clinical Trial Update: Platform Trial to Assess the Efficacy of Multiple Drugs in Amyotrophic Lateral Sclerosis (ALS) [Phase 3]
A Phase 3 platform trial to evaluate the efficacy of multiple drugs in Amyotrophic Lateral Sclerosis is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: RolloverTreatment With Triumeq for People With ALS Following the Lighthouse II Trial [Phase 3]
A Phase 3 trial evaluating rollover treatment with Triumeq for amyotrophic lateral sclerosis has been terminated.
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: CAN-PRIME: Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices [NA]
Neuralink's CAN-PRIME trial is evaluating a robotically implanted brain-computer interface to control external devices in people with tetrap…
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: A 6-Month Extension Study to Assess the Long-Term Safety of Engensis in Amyotrophic Lateral Sclerosis [Phase 2]
A 6-month extension study to assess the long-term safety of Engensis in amyotrophic lateral sclerosis has completed, with results posted on …
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CLINICAL_TRIALS trial_result · 2025-05-18Clinical Trial Update: A Second Intermediate-Size Expanded Access Protocol (EAP) for Pridopidine in People With Amyotrophic Lateral Sclerosis (Pridopidine EAP 2)
This clinical trial update indicates that the second intermediate-size Expanded Access Protocol for pridopidine in people with amyotrophic l…