Amyotrophic Lateral Sclerosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders
This clinical trial update describes a biospecimen biorepository study for amyotrophic lateral sclerosis, ALS-FTD, and related neurodegenera…
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CLINICAL_TRIALS research · 2025-12-09Clinical Trial Update: Lung Insufflation Capacity Training and Respiratory Function in Amyotrophic Lateral Sclerosis [NA]
Clinical trial update on lung insufflation capacity training and respiratory function in amyotrophic lateral sclerosis, currently recruiting…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Translating Single-cell Vulnerability Into Novel ALS Biomarkers and Therapeutic Targets: Towards a Liquid Nerve Biopsy
Clinical trial aiming to translate single-cell vulnerability into novel biomarkers and therapeutic targets for amyotrophic lateral sclerosis…
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CLINICAL_TRIALS research · 2025-12-05Clinical Trial Update: Continuous Measurement of Activity in Patients With Muscle Pathology and in Control Subjects. ActiSLA Part. [NA]
A clinical trial evaluating continuous measurement of activity in patients with muscle pathology and in control subjects, focusing on amyotr…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease. [NA]
This clinical trial update reports a currently recruiting study evaluating whether electrical stimulation affects facial pain, jaw movement,…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia [NA]
This document provides an update on BrainGate2, a feasibility study of an intracortical neural interface system for people with tetraplegia,…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia [NA]
This update describes a feasibility study of the BrainGate2 neural interface system in people with tetraplegia and related conditions, with …
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Imaging Biomarkers in ALS
The University of Minnesota is recruiting participants for a study on imaging biomarkers in amyotrophic lateral sclerosis and primary latera…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02) [NA]
This update describes a feasibility study of the BrainGate2 Neural Interface System in people with tetraplegia and related conditions; the t…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01) [NA]
This ClinicalTrials.gov entry documents a feasibility study of the BrainGate2 Neural Interface System in individuals with tetraplegia and re…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used in Daily Practice by ALS People [NA]
This clinical trial update describes the development and testing of a brain-computer interface headset intended for daily use by people with…
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases
A clinical trial conducted by Ospedale Policlinico San Martino is currently recruiting to investigate pathogenetic mechanisms and biomarkers…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures
This clinical trial update describes the Target ALS biomarker study investigating longitudinal biofluids, clinical measures, and at-home ass…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Evaluate the Safety and Efficacy of Intrathecal Injection of RJK002 in Patients With Amyotrophic Lateral Sclerosis [Phase 1]
A Phase 1 clinical trial evaluating the safety and efficacy of intrathecal injection of RJK002 in patients with Amyotrophic Lateral Sclerosi…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Brain Excitability and Connectivity in Sensory-motor Pathways in ALS [NA]
A completed clinical trial in France evaluated brain excitability and connectivity in sensory-motor pathways in amyotrophic lateral sclerosi…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Perception of Unpleasant Sensations During Study Procedures in ALS Patients
This clinical trial update reports the completion of a study in amyotrophic lateral sclerosis. It evaluates ALS patients' perceptions of unp…
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Resiliency Intervention for Patients With ALS and Their Care-Partners [NA]
This clinical trial update describes a resiliency intervention for people with amyotrophic lateral sclerosis and their care partners, curren…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: ALS/MND Natural History Study Data Repository
Clinical trial update announcing a natural history data repository study for ALS and related motor neuron diseases, with recruitment ongoing…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration [NA]
This is an update on Neuralink's VOICE study, an early feasibility trial of a robotically implanted brain-computer interface designed to res…
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CLINICAL_TRIALS research · 2025-10-30Clinical Trial Update: Trial of Oral Digoxin in Individuals With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
A Phase 2 trial evaluating oral digoxin in people with amyotrophic lateral sclerosis is currently active but not recruiting. The study is sp…
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CLINICAL_TRIALS research · 2025-10-28Clinical Trial Update: A Study of Ranolazine in ALS [Phase 2]
A Phase 2 clinical trial evaluating ranolazine in amyotrophic lateral sclerosis is currently recruiting.
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CLINICAL_TRIALS research · 2025-10-22Clinical Trial Update: Safety, Tolerability, and Exploratory Efficacy Study of Intrathecally Administered Gene Therapy AMT-162 in Adult Participants With SOD1 Amyotrophic Lateral Sclerosis (SOD1-ALS) [Phase 1, Phase 2]
A Phase 1/2 clinical trial update describing the safety, tolerability, and exploratory efficacy of intrathecally delivered AMT-162 gene ther…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: TRIAL READY (Clinical Trial Readiness)
The TRIAL READY clinical trial update (NCT03912987) shows the study is active but not recruiting, with conditions including amyotrophic late…
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: Identification of Early Markers for ALS [NA]
A France-sponsored clinical trial is currently recruiting to identify early markers for amyotrophic lateral sclerosis.
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: Remote Speech and Swallowing Assessment in ALS
Clinical trial update for a study evaluating remote speech and swallowing assessment in amyotrophic lateral sclerosis; the trial is currentl…