Acute Lymphoblastic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: Bleeding and Thrombotic Risk Prediction in Acute Leukemia: Clinical Utility of the Siriraj Acute Myeloid/Lymphoblastic Leukemia (SiAML) Score Versus Established Hemostatic Tools
This clinical trial aims to evaluate the clinical utility of the SiAML score versus established hemostatic tools for predicting bleeding and…
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide [Phase 2]
Phase 2 clinical trial evaluating HLA-mismatched unrelated donor bone marrow transplantation with post-transplant cyclophosphamide; the stud…
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: Study of Escalating Doses of INA03 Administered Intravenously as Single Agent in Adult Patients With Relapse/Refractory Acute Leukemia [EARLY_Phase 1]
An early-phase 1 study evaluated escalating intravenous doses of INA03 as a single agent in adults with relapsed or refractory acute leukemi…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Fourth-gen CAR T Cells Targeting CD19/CD22 for Highly Resistant B-cell Lymphoma/Leukemia (PMBCL/CNS-BCL). [Phase 1, Phase 2]
This Clinical Trial Update describes a fourth-generation CD19/CD22 dual-targeting CAR T-cell therapy being evaluated in Phase 1/2 for highly…
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: Impact of Low-intensity Chemotherapy Combined With Short-course Blinatumomab on Allo-HSCT in Adults With Ph- B-ALL [Phase 2]
Phase 2 trial update examining whether adding low-intensity chemotherapy to a short course of blinatumomab improves outcomes for adults with…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: ABO and Rh Blood Group Frequencies in Acute Leukemia Patients
A clinical trial conducted by Assiut University is investigating the frequencies of ABO and Rh blood groups in patients with acute leukemia …
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: Multicenter HomeVENT: Home Values and Experiences Navigation Track [NA]
A multicenter clinical trial sponsored by Johns Hopkins University is currently recruiting for the HomeVENT program’s Home Values and Experi…
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FDA approval · 2025-08-01FDA Approved: PHYRAGO — Supplemental Application (Cycle Pharmaceuticals Ltd)
The FDA has approved a supplemental application for PHYRAGO (dasatinib) from Cycle Pharmaceuticals Ltd.
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CLINICAL_TRIALS research · 2025-08-01Clinical Trial Update: Pediatric-inspired Regimen Combined With Venetoclax for Adolescent and Adult Patients With de Novo Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 clinical trial evaluating a pediatric-inspired regimen in combination with venetoclax for adolescents and adults with de novo Philad…
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CLINICAL_TRIALS trial_result · 2025-07-29Clinical Trial Update: 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome [Phase 1]
Phase 1 clinical trial evaluating 225Ac-DOTA-Anti-CD38 (daratumumab radiolabeled with Actinium-225) in combination with fludarabine, melphal…
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CLINICAL_TRIALS research · 2025-07-28Clinical Trial Update: Ex Vivo T-Cell-Depleted Haploidentical Transplantation Bridging With Chimeric Antigen Receptor T-cell Therapy and Prophylactic Memory T Cell Infusion for Acute Leukemia [NA]
This document provides a clinical trial update describing a novel transplantation approach for acute leukemia that combines ex vivo T-cell–d…
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CLINICAL_TRIALS research · 2025-07-25Clinical Trial Update: Reduced ATG Plus Mini PTCy for GVHD Prophylaxis in Haplo-SCT [Phase 2]
Phase 2 trial evaluating reduced ATG plus mini post-transplant cyclophosphamide for graft-versus-host disease prophylaxis in haploidentical …
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: A Phase 1 Study of FIT-CD19-CAR-T Cells in R/R B-ALL [Phase 1]
Phase 1 study evaluating FIT-CD19-CAR-T Cells for relapsed/refractory B-cell acute lymphoblastic leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: InterNatIonal CHildhood Leukemia Microbiome/MEtabolome Cohort
A multinational clinical trial update from Columbia University assessing the microbiome and metabolome in childhood acute lymphoblastic leuk…
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CLINICAL_TRIALS trial_result · 2025-07-20Clinical Trial Update: Haplo Peripheral Blood Sct In GVHD Prevention [Phase 1]
Phase 1 trial update reporting the completion of a haploidentical peripheral blood stem cell transplantation approach for the prevention of …
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CLINICAL_TRIALS research · 2025-07-20Clinical Trial Update: Femoral Arterial Cannulation in Pediatrics [NA]
A pediatric femoral arterial cannulation trial sponsored by American University of Beirut Medical Center is currently recruiting participant…
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CLINICAL_TRIALS research · 2025-07-18Clinical Trial Update: CD19 CAR-T Cell Infusion as Consolidation Therapy in Adolescent and Adult Patients With Acute B-ALL Ineligible for Allogeneic HSCT: A Clinical Study [Phase 1, Phase 2]
This clinical trial investigates CD19 CAR-T cell infusion as consolidation therapy for adolescents and adults with acute lymphoblastic leuke…
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CLINICAL_TRIALS trial_result · 2025-07-18Clinical Trial Update: Total Marrow and Lymphoid Irradiation and Chemotherapy Before DSCT in Treating Patients With High-Risk ALL or AML [Phase 2]
Phase 2 trial update evaluating total marrow and lymphoid irradiation plus chemotherapy before donor stem cell transplantation in high-risk …
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CLINICAL_TRIALS withdrawal · 2025-07-14Clinical Trial Update: TCRαβ/CD19 Depletion of Stem Cell Grafts for Transplant [NA]
A clinical trial evaluating TCRαβ/CD19-depleted stem cell grafts for transplantation has been withdrawn.
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Administration of Donor T Cells With the Caspase-9 Suicide Gene [Phase 1]
A Phase 1 trial evaluating donor T cells engineered with a caspase-9 suicide gene to enable controlled safety in hematologic diseases.
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CLINICAL_TRIALS trial_result · 2025-07-11Clinical Trial Update: CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene [Phase 1]
Phase 1 clinical trial of CASPALLO allodepleted T cells engineered with an inducible caspase-9 suicide gene; the study is currently active b…
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CLINICAL_TRIALS trial_result · 2025-07-11Clinical Trial Update: Telemedicine Optimized Burn Intervention [NA]
Completed clinical trial evaluating a telemedicine-optimized burn intervention. Results have been posted for conditions including burn injur…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling [Phase 1]
Phase 1 clinical trial evaluating ex vivo drug sensitivity testing and multi-omics profiling in pediatric cancers. Recruitment is ongoing ac…
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FDA approval · 2025-07-10FDA Approved: NILOTINIB — Supplemental Application (Cipla USA Inc.)
The FDA approved a supplemental application for nilotinib from Cipla USA Inc., indicating an approved update to the drug's labeling or indic…
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: Multicenter Study of Combined Chemotherapy and Transplantation for Adult ALL [Phase 2, Phase 3]
A multicenter Phase 2/3 clinical trial evaluating combined chemotherapy and transplantation for adult acute lymphoblastic leukemia is curren…