Uveal Melanoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Prospective Registration Of Patient Data and Quality of Life in Eye Melanoma Patients
An observational clinical trial registered to prospectively collect patient data and quality-of-life information in uveal melanoma patients;…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Neoadjuvant Tebentafusp for Uveal Melanoma [Phase 2]
This clinical trial update indicates a Phase 2 neoadjuvant trial of tebentafusp for locally advanced unresectable uveal melanoma is currentl…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Vorinostat in Treating Patients With Metastatic Melanoma of the Eye [Phase 2]
Phase 2 clinical trial update for Vorinostat in metastatic uveal melanoma of the eye. The study is sponsored by the National Cancer Institut…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma [Phase 2, Phase 3]
A randomized Phase 2/3 trial evaluating RP2 in combination with Nivolumab for metastatic uveal melanoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease [Phase 1]
Phase 1 study evaluating intravenous and intrathecal nivolumab for leptomeningeal disease in melanoma and non-small cell lung cancer patient…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal Melanoma [Phase 2]
This Phase 2 clinical trial is evaluating a combination of melphalan/HDS delivered via PHP with tebentafusp for metastatic uveal melanoma, w…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Study to Assess a PI3Kδ Inhibitor (IOA-244) in Patients With Metastatic Cancers [Phase 1]
Phase 1 trial update for IOA-244, a PI3Kδ inhibitor, being studied in metastatic cancers with status currently ACTIVE_NOT_RECRUITING.
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Neoadjuvant Immunotherapy for Patients With High-risk Eye Melanoma [Phase 1]
Phase 1 neoadjuvant immunotherapy trial for high-risk uveal melanoma has been updated. The study is currently not yet recruiting.
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Psychoeducation for Uveal Melanoma [NA]
A psychoeducation clinical trial for uveal melanoma is currently active but not recruiting, sponsored by the Jonsson Comprehensive Cancer Ce…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Identification of New Candidate Genes for Hereditary Predisposition to Uveal Melanoma [NA]
A clinical trial update describes a study identifying candidate genes that may predispose individuals to hereditary uveal melanoma, with rec…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: A Phase 1-1b Study to Evaluate the Safety, Efficacy and Dosimetry of Study Drug A9-3408 in Subjects With Metastatic Melanoma [Phase 1]
A Phase 1-1b clinical trial is evaluating the safety, preliminary efficacy, and dosimetry of study drug A9-3408 in patients with metastatic …
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal Melanoma [Phase 2]
Phase 2 clinical trial update evaluating sunitinib malate or valproic acid to prevent metastasis in high-risk uveal melanoma.
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: (Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma [Phase 2]
Phase 2 trial evaluating darovasertib (IDE196) as neoadjuvant/adjuvant therapy for localized uveal melanoma; the study is currently active b…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Immune Response to Percutaneous Hepatic Perfusion With Melphalan for Ocular Melanoma Metastatic to the Liver [NA]
A Massachusetts General Hospital-sponsored trial is evaluating the immune response to percutaneous hepatic perfusion with melphalan for live…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome
An ongoing clinical trial is recruiting to study the frequency and clinical phenotype of BAP1 tumor predisposition syndrome and its associat…
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: Neoadjuvant Tebentafusp in Patients With Metastatic Uveal Melanoma [Phase 2]
A Phase 2 neoadjuvant trial of tebentafusp for metastatic uveal melanoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Safety and Preliminary Efficacy of MBS8(1V270) in Cancer Patients With Advanced Solid Tumours [Phase 1]
Phase 1 study of the investigational therapy MBS8(1V270) evaluating safety and preliminary efficacy in patients with advanced solid tumors, …
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Study of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal Melanoma [Phase 2]
A Phase 2 clinical trial update assessing tebentafusp in combination with radioembolization for metastatic uveal melanoma, including liver m…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Choroidal Melanoma Patient-Reported Outcome Study (CM-PRO) in a Subset of AU-011-301 (CoMpass) Subjects
A patient-reported outcome study (CM-PRO) is being conducted in a subset of AU-011-301 (CoMpass) trial participants, with recruitment ongoin…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Neoadjuvant Darovasertib in Primary Uveal Melanoma [Phase 3]
A Phase 3 neoadjuvant trial of darovasertib for primary uveal melanoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma [Phase 2, Phase 3]
A Phase 2/3 clinical trial evaluating IDE196 (darovasertib) in combination with crizotinib as first-line therapy for metastatic uveal melano…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma [Phase 1]
This Phase 1 study evaluates LN-144 or LN-145 in people with advanced uveal melanoma, undifferentiated pleomorphic sarcoma, dedifferentiated…
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions [Phase 1, Phase 2]
A Phase 1/2 study evaluating darovasertib (IDE196), a PKC inhibitor, in patients with solid tumors harboring GNAQ/GNA11 mutations or PRKC fu…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: A Randomised Phase II Study of Roginolisib in Patients With Advanced/Metastatic Uveal Melanoma [Phase 2]
Phase II clinical trial update for Roginolisib in advanced/metastatic uveal melanoma; the study is active but not currently recruiting.
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas. [Phase 1]
This is a Phase 1 dose-escalation and expansion study evaluating intratumoral ONM-501 alone and in combination with cemiplimab in patients w…