Urothelial Carcinoma

• CLINICAL_TRIALS trial_result · 2025-07-09
  Clinical Trial Update: Trial of EP0057, a Nanoparticle Camptothecin With Olaparib in People With Relapsed/Refractory Small Cell Lung Cancer [Phase 1, Phase 2]

  NCI-sponsored trial EP0057 (camptothecin nanoparticle) combined with olaparib in relapsed/refractory small cell lung cancer completed Phase …

• CLINICAL_TRIALS trial_result · 2025-06-26
  Clinical Trial Update: Clofarabine Therapy in Locally Advanced or Metastatic Urothelial Carcinoma [Phase 1, Phase 2]

  This entry announces an ongoing Phase 1/2 clinical trial evaluating clo farabine therapy in locally advanced or metastatic urothelial carcin…

• CLINICAL_TRIALS research · 2025-06-17
  Clinical Trial Update: The Exploration of Novel Radionuclide-labeled HER2-targeting Antibodies in the Diagnosis of HER2-positive Malignancies [EARLY_Phase 1]

  An early-phase 1 trial evaluating a radionuclide-labeled HER2-targeting antibody for diagnostic use in HER2-positive cancers, with enrollmen…

• CLINICAL_TRIALS research · 2025-06-17
  Clinical Trial Update: PET Image Exploration of 89Zr-labeled Antibody Fragments Targeting HER2 in Patients With Malignant Tumors [EARLY_Phase 1]

  Early-phase PET imaging study evaluating 89Zr-labeled antibody fragments targeting HER2 in patients with malignant tumors to assess uptake a…

• CLINICAL_TRIALS withdrawal · 2025-06-15
  Clinical Trial Update: Copanlisib and Avelumab as a Maintenance Therapy for Advanced Bladder Cancer [Phase 1, Phase 2]

  This entry notes that the Phase 1/Phase 2 trial of copanlisib plus avelumab as maintenance therapy for advanced urothelial carcinoma has bee…

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• CLINICAL_TRIALS trial_result · 2025-06-10
  Clinical Trial Update: Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate [Phase 1]

  Phase 1 trial evaluating pembrolizumab with chemotherapy for locally advanced or metastatic small cell and neuroendocrine cancers of the uro…

• CLINICAL_TRIALS research · 2025-06-05
  Clinical Trial Update: Study Comparing the Standard Administration of IO Versus the Same IO Administered Each 3 Months in Patients in Response After 6 Months of Standard IO [Phase 3]

  A Phase 3 trial is evaluating whether an immune-oncology therapy given every three months after six months of standard administration is as …

• CLINICAL_TRIALS trial_result · 2025-06-05
  Clinical Trial Update: Multicohort Phase II Trial of sEphB4-HSA+Pembrolizumab in Solid Tumors [Phase 2]

  This is a Phase II multicohort trial assessing sEphB4-HSA in combination with pembrolizumab for solid tumors; the study is currently active …

• CLINICAL_TRIALS research · 2025-06-05
  Clinical Trial Update: Observational Study of Muscle Invasive Urothelial Carcinoma Participants Treated With Adjuvant Nivolumab in France

  An observational study of muscle-invasive urothelial carcinoma patients treated with adjuvant nivolumab in France has been terminated.

• CLINICAL_TRIALS trial_result · 2025-05-31
  Clinical Trial Update: STRATA: Safe Testing of Risk for AsymptomaTic MicrohematuriA [NA]

  A completed trial evaluating a safe testing approach for risk of asymptomatic microscopic hematuria associated with urothelial carcinoma.

• CLINICAL_TRIALS research · 2025-05-29
  Clinical Trial Update: Clinical Application of PET Imaging Targeting Nectin-4 in Malignant Tumors [NA]

  A clinical trial update describes PET imaging targeting Nectin-4 in malignant tumors and lists urothelial carcinoma, breast cancer, and lung…

• CLINICAL_TRIALS research · 2025-05-22
  Clinical Trial Update: Diagnostic Efficacy and Dosimetry of MNPR-101-DFO*-89Zr in Patients With Solid Tumors [Phase 1]

  This ClinicalTrials.gov update describes a Phase 1 study evaluating MNPR-101-DFO*-89Zr as a diagnostic imaging agent for adults with various…

• CLINICAL_TRIALS research · 2025-05-21
  Clinical Trial Update: A Patient-Directed Mobile Tool to Streamline the QoL Assessment and Monitoring in Urothelial Carcinoma

  This clinical trial entry describes a patient-directed mobile tool to streamline quality-of-life assessment and monitoring in urothelial car…

• CLINICAL_TRIALS trial_result · 2025-05-21
  Clinical Trial Update: Dose-Escalation of MNPR-101-PCTA-177Lu in Solid Tumors [Phase 1]

  Phase 1 dose-escalation study of MNPR-101-PCTA-177Lu in solid tumors is currently recruiting across multiple cancer indications.

• CLINICAL_TRIALS research · 2025-05-20
  Clinical Trial Update: Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01) [Phase 1, Phase 2]

  KL264-01, a Trop2-targeted antibody-drug conjugate, is being studied in a Phase 1/2 trial for advanced unresectable or metastatic solid tumo…

• CLINICAL_TRIALS trial_result · 2025-05-14
  Clinical Trial Update: A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations [Phase 3]

  Phase 3 study comparing erdafitinib with vinflunine, docetaxel, or pembrolizumab in advanced urothelial carcinoma with FGFR gene alterations…

• CLINICAL_TRIALS trial_result · 2025-05-13
  Clinical Trial Update: Phase 1/2 Study of APR-246 in Combination With Pembrolizumab in Subjects With Solid Tumor Malignancies [Phase 1, Phase 2]

  A Phase 1/2 clinical trial evaluating APR-246 in combination with pembrolizumab in solid tumors has completed enrollment with results posted…

• CLINICAL_TRIALS trial_result · 2025-05-07
  Clinical Trial Update: A Study to Evaluate KIN-3248 in Participants With Advanced Tumors Harboring FGFR2 and//or FGFR3 Gene Alterations [Phase 1]

  Phase 1 study of KIN-3248 in FGFR2/3-altered advanced tumors was terminated. The trial enrolled patients with intrahepatic cholangiocarcinom…

• CLINICAL_TRIALS research · 2025-05-07
  Clinical Trial Update: A Study of BL-B01D1 + PD-1 in Patients With Locally Advanced or Metastatic Urothelial Carcinoma [Phase 2]

  Phase 2 study evaluating BL-B01D1 in combination with a PD-1 inhibitor for locally advanced or metastatic urothelial carcinoma is currently …

• CLINICAL_TRIALS trial_result · 2025-05-04
  Clinical Trial Update: Neoadjuvant and Adjuvant Durvalumab in Combination With Neoadjuvant Chemotherapy in Patients With Operable Urothelial Cancer. [Phase 2]

  Phase 2 trial of durvalumab in combination with neoadjuvant chemotherapy for operable urothelial cancer has completed.

• CLINICAL_TRIALS trial_result · 2025-04-27
  Clinical Trial Update: A Study to Evaluate the Clinical Efficacy of JNJ-42756493 (Erdafitinib), A Pan-Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinase Inhibitor, In Asian Participants With Advanced Non-Small-Cell Lung Cancer, Urothelial Cancer, Esophageal Cancer Or Cholangiocarcinoma [Phase 2]

  A Phase 2 study completed in Asian participants evaluated Erdafitinib, a pan-FGFR tyrosine kinase inhibitor, for efficacy in advanced non-sm…

• CLINICAL_TRIALS trial_result · 2025-04-24
  Clinical Trial Update: Study of Atezolizumab Combined With Split-dose Gemcitabine Plus Cisplatin in Urothelial Carcinoma [Phase 2]

  Phase 2 study evaluating atezolizumab with split-dose gemcitabine plus cisplatin for locally advanced or metastatic urothelial carcinoma has…

• CLINICAL_TRIALS research · 2025-04-13
  Clinical Trial Update: A Study to Evaluate 9MW2821 Versus Chemotherapy in Subjects With Previously Treated Locally Advanced or Metastatic Urothelial Cancer [Phase 3]

  A Phase 3 clinical trial is evaluating 9MW2821 versus chemotherapy in patients with previously treated locally advanced or metastatic urothe…

• CLINICAL_TRIALS research · 2025-04-13
  Clinical Trial Update: Bladder Cancer Screening Trial [NA]

  A bladder cancer screening trial sponsored by the University of Texas Southwestern Medical Center is currently recruiting, investigating bla…

• CLINICAL_TRIALS trial_result · 2025-04-11
  Clinical Trial Update: Brazilian Reality of Urinary Bladder Cancers - BRA-BLADDER

  AstraZeneca-sponsored BRA-BLADDER study evaluating bladder cancer in Brazil has completed, examining urothelial carcinoma across non-muscle …