Undifferentiated Pleomorphic Sarcoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg [Phase 2]
Phase 2 trial evaluating pembrolizumab plus local chemotherapy delivered by isolated limb infusion for patients with sarcoma in the arm or l…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas [Phase 3]
This Phase 3 trial is evaluating whether adding immunotherapy to chemotherapy improves outcomes versus chemotherapy alone in patients with a…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue Sarcoma [Phase 2]
A Phase 2 clinical trial update describes testing the combination of ipilimumab and nivolumab with or without cabozantinib in adults with ad…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma [Phase 1]
Phase 1 trial evaluating the safety of low-dose pegylated liposomal doxorubicin in combination with peposertib for advanced sarcoma; current…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery [Phase 2]
Clinical trial update for a Phase 2 study evaluating Talimogene laherparepvec with radiation therapy in newly diagnosed soft tissue sarcoma …
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma [Phase 1]
Phase 1 trial evaluating nivolumab plus BO-112 as a neoadjuvant treatment before surgery for resectable soft tissue sarcoma, including multi…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients [NA]
Trial update reporting prospective identification of predictive biomarkers for trabectedin efficacy across non-liposarcoma soft tissue sarco…
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CLINICAL_TRIALS trial_result · 2026-03-05Clinical Trial Update: Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before Surgery [Phase 2]
This is a Phase 2 clinical trial evaluating nivolumab with or without ipilimumab, plus radiation therapy, in patients with recurrent or rese…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas [NA]
Investigates regorafenib as maintenance therapy after first-line treatment in patients with bone sarcomas and related subtypes. The trial is…
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CLINICAL_TRIALS trial_result · 2026-02-13Clinical Trial Update: Pembrolizumab and Gemcitabine Chemotherapy in Leiomyosarcoma and Undifferentiated Pleomorphic Sarcoma [Phase 1, Phase 2]
This update reports the completion and posted results of a Phase 1/2 trial evaluating pembrolizumab in combination with gemcitabine chemothe…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma [Phase 1]
This Phase 1 study evaluates LN-144 or LN-145 in people with advanced uveal melanoma, undifferentiated pleomorphic sarcoma, dedifferentiated…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma. [Phase 2]
Clinical trial evaluating dose-escalated, hypofractionated definitive proton radiotherapy for patients with inoperable soft tissue sarcoma (…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma [Phase 2]
Phase 2 clinical trial update evaluating hypofractionated, 3-week preoperative radiotherapy using proton or photon therapy for localized sof…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma [Phase 1]
Phase 1 clinical trial evaluating HER2-targeted CAR T cells in combination with checkpoint blockade for advanced sarcoma; recruitment is ong…
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CLINICAL_TRIALS other · 2025-10-07Clinical Trial Update: Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas [Phase 2]
A Phase 2 trial evaluating the combination of pembrolizumab and cabozantinib in advanced soft tissue sarcomas, including Ewing sarcoma, oste…
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CLINICAL_TRIALS trial_result · 2025-09-23Clinical Trial Update: CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With Sarcoma [Phase 1, Phase 2]
Clinical trial update indicates the Phase 1/Phase 2 safety and efficacy study of CAB-AXL-ADC in adult and adolescent patients with Undiffere…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors [Phase 1]
Phase 1 first-in-human trial evaluating OKN4395 in combination with pembrolizumab in patients with solid tumors is currently recruiting. The…
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CLINICAL_TRIALS trial_result · 2025-08-28Clinical Trial Update: A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue Sarcomas [Phase 2]
A Phase II study evaluating the combination of eribulin and pembrolizumab in soft tissue sarcomas has completed, with results posted.
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CLINICAL_TRIALS trial_result · 2025-08-28Clinical Trial Update: Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas [Phase 1]
Phase 1 study of DCC-3014 in combination with Avelumab in patients with advanced or metastatic sarcoma has completed; no efficacy data is pr…
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: Focused Ultrasound to Promote Immune Responses for Undifferentiated Pleomorphic Sarcoma [NA]
An update on an ongoing clinical trial investigating focused ultrasound to promote immune responses in undifferentiated pleomorphic sarcoma,…
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CLINICAL_TRIALS research · 2025-07-24Clinical Trial Update: MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma [Phase 2]
A Phase 2 trial evaluating MASCT-I in combination with doxorubicin and ifosfamide as first-line therapy for advanced soft tissue sarcoma is …
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CLINICAL_TRIALS trial_result · 2024-11-12Clinical Trial Update: Sintilimab for the Treatment of Locally Advanced, Metastatic, Recurrent, or Unresectable Undifferentiated Pleomorphic Sarcoma, SiARa Cancer Study [Phase 2]
Phase 2 trial update evaluating sintilimab for undifferentiated pleomorphic sarcoma; study terminated with results posted.
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CLINICAL_TRIALS withdrawal · 2024-07-17Clinical Trial Update: Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma [Phase 3]
A Phase 3 trial (Brightline-3) testing brigimadlin in combination with ezabenlimab for advanced soft tissue sarcoma, including undifferentia…
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CLINICAL_TRIALS research · 2024-05-17Clinical Trial Update: ENVASARC: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma [Phase 2]
This is a Phase 2 clinical trial update for envafolimab, administered alone or with ipilimumab, in patients with undifferentiated pleomorphi…
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CLINICAL_TRIALS trial_result · 2024-05-08Clinical Trial Update: Itacitinib in Treating Patients With Refractory Metastatic/Advanced Sarcomas [Phase 1]
Itacitinib was studied in a Phase 1 trial for patients with refractory metastatic/advanced sarcomas, but the study status is TERMINATED.