Tuberculosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2017-05-03Clinical Trial Update: Evaluation of PCR Using DNA Extract From Slides and Filter Paper for the Detection of Tuberculosis and MDR-tuberculosis
Completed clinical trial evaluating PCR on DNA extracted from slides and filter paper for detection of tuberculosis and multidrug-resistant …
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FDA approval · 2017-04-24FDA Approved: RIFADIN IV — Supplemental Application (Sanofi-Aventis U.S. LLC)
FDA approved a supplemental application for Rifadin IV (rifampin) by Sanofi-Aventis U.S. LLC.
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CLINICAL_TRIALS trial_result · 2017-04-21Clinical Trial Update: TMC207 +/- Rifabutin/Rifampin [Phase 1]
Phase 1 study evaluating bedaquiline (TMC207) with or without rifabutin or rifampin in tuberculosis has completed. The update notes the tria…
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CLINICAL_TRIALS trial_result · 2017-04-20Clinical Trial Update: Rifapentine Plus Moxifloxacin for Treatment of Pulmonary Tuberculosis [Phase 2]
A Phase 2 trial evaluating rifapentine plus moxifloxacin for pulmonary tuberculosis was terminated. Results were posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-04-19Clinical Trial Update: Linkage and Retention: A Randomized Trial to Optimize HIV/TB Care in South Africa [NA]
A randomized trial completed in South Africa aimed at improving linkage to care and retention for individuals with HIV/TB co-infection.
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CLINICAL_TRIALS trial_result · 2017-04-13Clinical Trial Update: Whole Blood Bactericidal Activity Against Mycobacterium Tuberculosis of Pyrazinamide Plus Allopurinol in Healthy Volunteers [Phase 1]
Phase 1 study evaluating the bactericidal activity of pyrazinamide in combination with allopurinol against Mycobacterium tuberculosis in hea…
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CLINICAL_TRIALS trial_result · 2017-04-13Clinical Trial Update: Evaluating Celecoxib Activity in Mycobacterium Tuberculosis: A Whole Blood Bactericidal Activity Study in Healthy Volunteers [Phase 1]
Phase 1 trial evaluating whether celecoxib exhibits whole-blood bactericidal activity against tuberculosis in healthy volunteers; the study …
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CLINICAL_TRIALS research · 2017-04-13Clinical Trial Update: Evaluation of Somatostatin Receptor Imaging Using PET/MRI as a Novel Approach to Detecting Pathology in Pulmonary TB [Phase 1]
This clinical trial update describes a Phase 1 evaluation of somatostatin receptor imaging using PET/MRI to detect pathology in pulmonary tu…
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CLINICAL_TRIALS trial_result · 2017-04-13Clinical Trial Update: Whole Blood Bactericidal Activity (WBA) Against Mycobacterium Tuberculosis of Rifampicin in Healthy Volunteers [Phase 1]
A Phase 1 study evaluating whole blood bactericidal activity of rifampicin against Mycobacterium tuberculosis in healthy volunteers. The tri…
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CLINICAL_TRIALS trial_result · 2017-04-05Clinical Trial Update: Whole Blood Bactericidal Activity (WBA) Against Mycobacterium Tuberculosis of Faropenem Plus Amoxicillin/Clavulanic Acid in Healthy Volunteers [Phase 1]
Phase 1 trial in healthy volunteers evaluating the whole blood bactericidal activity of a combination of faropenem and amoxicillin/clavulani…
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CLINICAL_TRIALS trial_result · 2017-04-04Clinical Trial Update: Essentiality of INH in TB Therapy [Phase 2]
This Phase 2 clinical trial update evaluates the essential role of isoniazid (INH) in tuberculosis therapy.
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CLINICAL_TRIALS withdrawal · 2017-04-04Clinical Trial Update: A RCT of Prednisone as Adjunctive Therapy for Hospitalized Patients With Pulmonary TB and HIV Co-infection [Phase 3]
A Phase 3 randomized trial of prednisone as adjunctive therapy for hospitalized patients with pulmonary tuberculosis and HIV co-infection wa…
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CLINICAL_TRIALS trial_result · 2017-03-24Clinical Trial Update: Dose-Escalation Study to Evaluate the Safety and Immunogenicity of MTBVAC Vaccine in Comparison With BCG Vaccine. [Phase 1]
Phase 1 dose-escalation study comparing the safety and immunogenicity of the MTBVAC vaccine to the BCG vaccine has completed, with results p…
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CLINICAL_TRIALS trial_result · 2017-03-23Clinical Trial Update: Phase IIb Clinical Study of Recombinant Mycobacterium Tuberculosis Allergen ESAT6-CFP10 [Phase 2]
A Phase IIb clinical study evaluating the recombinant Mycobacterium tuberculosis allergen ESAT6-CFP10 for tuberculosis has completed.
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CLINICAL_TRIALS trial_result · 2017-03-23Clinical Trial Update: Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana [Phase 2]
Phase 2 clinical trial investigating concomitant infections of Mansonella perstans in patients with tuberculosis and Buruli ulcer disease in…
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CLINICAL_TRIALS trial_result · 2017-03-22Clinical Trial Update: Quality of Tuberculosis Care in Urban Patna, India [NA]
A completed clinical trial evaluating the quality of tuberculosis care in urban Patna, India.
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CLINICAL_TRIALS trial_result · 2017-03-17Clinical Trial Update: Phase IIb Clinical Study of Recombinant Mycobacterium Tuberculosis Allergen ESAT6-CFP10 on Healthy People Aged 18-65 [Phase 2]
A Phase IIb trial evaluating the recombinant Mycobacterium tuberculosis allergen ESAT6-CFP10 in healthy adults aged 18-65 has completed.
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CLINICAL_TRIALS research · 2017-03-06Clinical Trial Update: Nasal, Tracheal and Bronchial Mucosal Lining Fluid(MLF) Sampling From Patients With Respiratory Diseases
This clinical trial update describes sampling of nasal, tracheal, and bronchial mucosal lining fluid from patients with various respiratory …
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CLINICAL_TRIALS trial_result · 2017-02-08Clinical Trial Update: Comparative Study of Bacille Calmette Guerin (BCG) Delivery Via Disposable Syringe Jet Injector and Needle & Syringe [NA]
A PATH-sponsored clinical trial compared Bacille Calmette-Guérin (BCG) vaccine delivery by a disposable syringe jet injector versus the trad…
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CLINICAL_TRIALS trial_result · 2017-02-03Clinical Trial Update: Safety and Immunogenicity Study of GSK Biologicals Tuberculosis Vaccines (692342) to Healthy Adults [Phase 2]
Phase 2 safety and immunogenicity trial of GSK tuberculosis vaccines in healthy adults completed; results posted.
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CLINICAL_TRIALS trial_result · 2017-02-02Clinical Trial Update: Tuberculosis Recurrence Upon Treatment With Highly Active Antiretroviral Therapy
A completed CAPRISA study examines tuberculosis recurrence in people receiving highly active antiretroviral therapy (ART) for HIV in South A…
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CLINICAL_TRIALS research · 2017-02-01Clinical Trial Update: Substudy of Protocol TB-018 (NCT01755598): Collection and Storage of Biological Samples for Evaluation of Correlates of TB (C-041-972)
This update notes the completion of a substudy under Protocol TB-018 that collects and stores biological samples to evaluate correlates of t…
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CLINICAL_TRIALS trial_result · 2017-01-24Clinical Trial Update: Safety and Immunogenicity of a Candidate Tuberculosis (TB) Vaccine in Adults With TB Disease [Phase 2]
Phase 2 trial assessing safety and immunogenicity of a candidate TB vaccine in adults with tuberculosis has been terminated with results pos…
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CLINICAL_TRIALS trial_result · 2017-01-24Clinical Trial Update: A Study for Safety and Immunogenicity of BCG and AERAS-404 in HIV-Negative, TB-Negative, BCG-Naive Adults [Phase 1]
This Phase 1 trial assessed the safety and immunogenicity of BCG and the AERAS-404 TB vaccine in HIV-negative, TB-negative, BCG-naive adults…
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CLINICAL_TRIALS trial_result · 2017-01-11Clinical Trial Update: Reactogenicity, Safety and Immunogenicity of a TB/FLU-01L Tuberculosis Vaccine [Phase 1]
This document reports the results of a Phase 1 trial evaluating the reactogenicity, safety, and immunogenicity of the TB/FLU-01L tuberculosi…