Treatment-resistant Depression
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CLINICAL_TRIALS trial_result · 2017-08-24Clinical Trial Update: A Study of Olanzapine and Fluoxetine for Treatment-resistant Depression [Phase 3]
Phase 3 trial investigating olanzapine and fluoxetine for treatment-resistant depression has been terminated with posted results.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Proof-of-Concept Trial of CERC-501 Augmentation of Antidepressant Therapy in Treatment-Resistant Depression [Phase 2]
Phase 2 proof-of-concept trial evaluating augmentation of antidepressant therapy with CERC-501 in treatment-resistant depression was termina…
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Trial of Low Field Magnetic Stimulation Augmentation of Antidepressant Therapy in Treatment-Resistant Depression [NA]
A completed clinical trial evaluating low field magnetic stimulation as an augmentation to antidepressant therapy for treatment-resistant de…
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CLINICAL_TRIALS research · 2017-04-26Clinical Trial Update: A Clinical Evaluation of Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression [NA]
An update on a clinical evaluation of Subcallosal Cingulate Gyrus Deep Brain Stimulation for treatment-resistant depression, sponsored by Ab…
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CLINICAL_TRIALS withdrawal · 2017-02-17Clinical Trial Update: Ultrabrief Right Unilateral and Brief Pulse Bitemporal Electroconvulsive Therapy [NA]
This clinical trial update reports the withdrawal of a Kaiser Permanente study evaluating ultrabrief right unilateral and brief-pulse electr…
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CLINICAL_TRIALS research · 2016-09-21Clinical Trial Update: Clinical Trial of the Use of Ketamine in Treatment Resistant Depression [Phase 4]
This entry notes a Phase 4 clinical trial evaluating ketamine for treatment-resistant depression, with the trial status currently unknown.
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CLINICAL_TRIALS trial_result · 2016-09-05Clinical Trial Update: Minocycline as an Adjunct for the Treatment of Depressive Symptoms: Pilot Randomized Controlled Trial [Phase 4]
This completed Phase 4 pilot randomized trial evaluated minocycline as an adjunct therapy for depressive symptoms.
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CLINICAL_TRIALS research · 2016-07-28Clinical Trial Update: Inflammatory Markers and Resistant Depression [NA]
This clinical trial update examines inflammatory markers in major depressive disorder and treatment-resistant depression, with the trial sta…
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CLINICAL_TRIALS trial_result · 2016-05-13Clinical Trial Update: D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression [Phase 4]
A Phase 4 clinical trial update evaluating D-cycloserine for relapse prevention after intravenous ketamine treatment in treatment-resistant …
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CLINICAL_TRIALS trial_result · 2016-05-02Clinical Trial Update: An Open Label Study of Clinical Utility and Patient Outcomes of the Genecept Assay [NA]
Open-label study evaluating the clinical utility and patient outcomes of the Genecept Assay in treatment-resistant depression and generalize…
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CLINICAL_TRIALS research · 2016-04-06Clinical Trial Update: Focal Electrically Administered Seizure Therapy for the Treatment of Depression [NA]
Update on a clinical trial evaluating focal electrically administered seizure therapy for treatment-resistant depression; current status of …
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CLINICAL_TRIALS withdrawal · 2016-01-05Clinical Trial Update: e-PAT Neuromod Evaluation of Personalized rTMS for Resistant Depression [Phase 2]
A Phase 2 clinical trial evaluating personalized e-PAT neuromodulation with repetitive transcranial magnetic stimulation for treatment-resis…
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CLINICAL_TRIALS trial_result · 2015-10-12Clinical Trial Update: Cognitive and Drug Therapy for Drug-Resistant Depression [NA]
A completed clinical trial evaluating cognitive and pharmacologic therapies for treatment-resistant depression.
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CLINICAL_TRIALS trial_result · 2015-08-26Clinical Trial Update: Pulsating ElectroMagnetive Treatment (PEMF) at Treatment Resistant Depression [Phase 3]
Phase 3 clinical trial evaluating Pulsating Electromagnetic Treatment (PEMF) for treatment-resistant depression has completed, sponsored by …
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CLINICAL_TRIALS trial_result · 2015-03-17Clinical Trial Update: Ketamine for Treatment-resistant Depression: A Multicentric Clinical Trial in Mexican Population [Phase 2]
This document reports a Phase 2 multicenter clinical trial evaluating ketamine for treatment-resistant depression in a Mexican population. T…
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CLINICAL_TRIALS trial_result · 2014-03-06Clinical Trial Update: Exercise in Treatment Resistant Depression (TRD): A Feasibility Study [NA]
A completed feasibility trial investigating exercise as a treatment option for treatment-resistant depression.
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CLINICAL_TRIALS trial_result · 2014-01-31Clinical Trial Update: Optimization of IV Ketamine for Treatment Resistant Depression [Phase 2]
Phase 2 trial assessing optimized IV ketamine dosing for treatment-resistant depression (and major depressive disorder); results were posted…
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CLINICAL_TRIALS research · 2013-08-13Clinical Trial Update: Functional and Neurochemical Correlates of Treatment Response in Major Depressive Disorder
This terminated clinical trial explored functional and neurochemical correlates of treatment response in major depressive disorder with trea…
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CLINICAL_TRIALS research · 2013-07-11Clinical Trial Update: Interpersonal Psychotherapy for Treatment Resistant Depression [NA]
This clinical trial update concerns interpersonal psychotherapy for treatment-resistant depression. The current status is unknown and no res…
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CLINICAL_TRIALS trial_result · 2013-02-25Clinical Trial Update: Study Comparing Outcomes for Patients With Treatment Resistant Depression Who Receive VNS Therapy at Different Doses [Phase 4]
A Phase 4 study reports results comparing outcomes for treatment-resistant depression patients treated with VNS therapy at different dose le…
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FDA approval · 2012-12-31FDA Approved: OLANZAPINE AND FLUOXETINE — Supplemental Application (Teva Pharmaceuticals USA, Inc.)
The FDA approved Teva's supplemental application for a generic olanzapine and fluoxetine product. This expands access to the olanzapine/fluo…
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CLINICAL_TRIALS trial_result · 2012-07-10Clinical Trial Update: Efficacy, Safety and Tolerability of CX157 in Treatment Resistant Depression [Phase 2]
Phase 2 trial results update describing the efficacy, safety and tolerability of CX157 in treatment-resistant depression.
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CLINICAL_TRIALS trial_result · 2012-05-23Clinical Trial Update: Comparing Quetiapine XR Monotherapy and Augmentation With Lithium Augmentation in TRD Patients [Phase 3]
Phase 3 clinical trial comparing quetiapine XR as monotherapy versus augmentation with lithium in treatment-resistant depression. Results we…
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CLINICAL_TRIALS withdrawal · 2011-06-06Clinical Trial Update: Ketamine Frequency Treatment for Major Depressive Disorder [Phase 4]
A Phase 4 clinical trial investigating a ketamine frequency treatment for major depressive disorder has been withdrawn.
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CLINICAL_TRIALS trial_result · 2008-03-04Clinical Trial Update: An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant Depression [Phase 2]
A Phase 2 trial evaluating whether adding the 5-HT2A antagonist M100907 to citalopram improves outcomes in treatment-resistant depression; t…