Treatment-resistant Depression
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CLINICAL_TRIALS trial_result · 2024-11-04Clinical Trial Update: Efficacy of Convulsive Therapies During Continuation [NA]
Completed study evaluating the efficacy of convulsive therapies during the continuation phase for depression, including unipolar, bipolar, a…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006) [Phase 2]
Phase 2 trial evaluating MK-1942 added to stable antidepressant therapy in treatment-resistant depression was terminated, with results poste…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Stepped Care AiTBS 2 Depression Study (Ghent) [NA]
Clinical trial update for the Stepped Care AiTBS 2 Depression Study in Ghent; the study involving major depressive disorder and treatment-re…
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CLINICAL_TRIALS trial_result · 2024-08-06Clinical Trial Update: Computational Psychiatric Approach to Depression
A Wake Forest University Health Sciences study on a computational psychiatric approach to depression has completed, covering depression and …
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CLINICAL_TRIALS trial_result · 2024-06-04Clinical Trial Update: A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD [Phase 2]
This document reports the results of a Phase 2 randomized, double-blind, placebo-controlled trial evaluating PCN-101 for treatment-resistant…
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CLINICAL_TRIALS trial_result · 2024-05-29Clinical Trial Update: Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression
A completed clinical trial update reporting safety and tolerability observations over one year after treatment with R-ketamine versus placeb…
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CLINICAL_TRIALS trial_result · 2024-05-08Clinical Trial Update: Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial [Phase 4]
Phase 4 randomized controlled pilot trial evaluating nitrous oxide exposure for sustained mood improvement in treatment-resistant depression…
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CLINICAL_TRIALS trial_result · 2024-02-09Clinical Trial Update: Stellate Ganglion Block for Major Depressive Disorder. [Phase 4]
Phase 4 clinical trial update on stellate ganglion block as treatment for treatment-resistant depression and major depressive disorder has c…
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CLINICAL_TRIALS trial_result · 2024-02-09Clinical Trial Update: Predictors of Intravenous Ketamine Response in TRD [Phase 3]
A Phase 3 trial update investigating predictors of intravenous ketamine response in treatment-resistant depression and major depressive diso…
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CLINICAL_TRIALS trial_result · 2024-01-31Clinical Trial Update: Salicylic Augmentation in Depression [Phase 2]
Phase 2 trial investigating salicylic augmentation in depression was terminated; results posted in 2024.
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CLINICAL_TRIALS trial_result · 2023-12-05Clinical Trial Update: Deep Brain Stimulation for Treatment Resistant Depression [Phase 1, Phase 2]
Clinical trial update for deep brain stimulation as a treatment for treatment-resistant depression (Phase 1/Phase 2).
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CLINICAL_TRIALS trial_result · 2023-11-28Clinical Trial Update: The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive Disorder [Phase 2, Phase 3]
Phase 2/3 clinical trial investigating the safety and efficacy of fecal microbiota transplantation in individuals with major depressive diso…
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CLINICAL_TRIALS trial_result · 2023-11-09Clinical Trial Update: The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression [Phase 2]
Phase 2 trial results assessing psilocybin as an adjunctive therapy for treatment-resistant depression have been completed with posted resul…
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CLINICAL_TRIALS trial_result · 2023-08-22Clinical Trial Update: Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression [Phase 4]
Phase 4 trial comparing augmentation strategies (amantadine, pramipexole, and quetiapine) for treatment-resistant depression.
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CLINICAL_TRIALS trial_result · 2023-08-15Clinical Trial Update: Clinical Study of GH001 in Depression [Phase 1, Phase 2]
Phase 1/2 clinical study of GH001 for treatment-resistant depression and major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2023-08-09Clinical Trial Update: ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) [Phase 2, Phase 3]
A completed phase 2/3 trial comparing electroconvulsive therapy (ECT) to ketamine for treatment-resistant depression, with results posted in…
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CLINICAL_TRIALS trial_result · 2023-07-27Clinical Trial Update: Psilocybin for Treatment-Resistant Depression [Phase 2]
Phase 2 clinical trial update for psilocybin in treatment-resistant depression; study completed.
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CLINICAL_TRIALS trial_result · 2023-05-18Clinical Trial Update: Repetitive Transcranial Magnetic Stimulation for Adolescent Depression: Efficacy, Predictive Biomarkers, and Mechanisms [NA]
Clinical trial update on repetitive transcranial magnetic stimulation for adolescent treatment-resistant depression, including efficacy, pre…
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CLINICAL_TRIALS trial_result · 2023-04-24Clinical Trial Update: The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression [Phase 2]
Phase 2 trial update on the safety and efficacy of psilocybin in treatment-resistant depression; results posted after completion.
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CLINICAL_TRIALS trial_result · 2023-02-08Clinical Trial Update: Ketamine for Older Adults Pilot [Phase 4]
Pilot Phase 4 trial investigating ketamine for treatment resistant depression in older adults has completed with results posted.
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CLINICAL_TRIALS trial_result · 2022-10-25Clinical Trial Update: The Safety and Efficacy of Psilocybin in Participants With Type 2 Bipolar Disorder (BP-II) Depression. [Phase 2]
Phase 2 trial update evaluating safety and efficacy of psilocybin for treatment-resistant depression in adults with bipolar II disorder.
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CLINICAL_TRIALS trial_result · 2022-10-12Clinical Trial Update: Open-Label Safety Study of AXS-05 in Subjects With Depression [Phase 3]
Open-label safety study of AXS-05 in subjects with depression completed; results posted in 2022.
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CLINICAL_TRIALS trial_result · 2022-07-12Clinical Trial Update: Mechanistic Evaluation of Response in TRD (MERIT) [Phase 2]
Phase 2 clinical trial evaluating mechanistic response in treatment resistant depression and major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2022-05-24Clinical Trial Update: Optimizing Outcomes of Treatment-Resistant Depression in Older Adults [Phase 4]
Phase 4 trial update evaluating outcomes for treatment-resistant depression in older adults; results were posted in May 2022.
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CLINICAL_TRIALS trial_result · 2022-05-20Clinical Trial Update: Psilocybin Versus Ketamine in Treatment-Resistant Depression [Phase 2]
Phase 2 trial update comparing psilocybin to ketamine in treatment-resistant depression (NCT05383313).