Treatment-resistant Depression
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CLINICAL_TRIALS trial_result · 2025-09-05Clinical Trial Update: Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression [Phase 4]
A Phase 4 trial evaluated low-dose ketamine infusions in adolescents with treatment-resistant depression and major depressive disorder. The …
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CLINICAL_TRIALS trial_result · 2025-08-20Clinical Trial Update: Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression [NA]
A completed clinical trial evaluating the effect of psilocybin on the positive valence system in treatment-resistant depression.
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CLINICAL_TRIALS trial_result · 2025-08-15Clinical Trial Update: Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression [NA]
A confirmatory efficacy and safety trial of Magnetic Seizure Therapy for depression has completed.
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CLINICAL_TRIALS trial_result · 2025-08-05Clinical Trial Update: 2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation
A two-year study evaluating vagus nerve stimulation for higher-grade treatment-resistant depression reports clinical outcomes and includes a…
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CLINICAL_TRIALS trial_result · 2025-07-22Clinical Trial Update: MBCT and Escitalopram for Treatment-Resistant Depression in Older Adults [NA]
The clinical trial evaluating mindfulness-based cognitive therapy (MBCT) plus escitalopram for treatment-resistant depression in older adult…
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CLINICAL_TRIALS trial_result · 2025-07-18Clinical Trial Update: BPL-003 Efficacy and Safety in Treatment Resistant Depression [Phase 2]
Phase 2 trial evaluating BPL-003 for treatment-resistant depression has completed, reporting efficacy and safety findings.
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CLINICAL_TRIALS trial_result · 2025-06-27Clinical Trial Update: Ketamine Associated ACC GABA and Glutamate Change and Depression Remission: [EARLY_Phase 1]
This early-phase trial reports ketamine-associated changes in ACC GABA and glutamate and notes depression remission. The study targets major…
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression. [EARLY_Phase 1]
This early-phase, completed trial evaluated ethosuximide in patients with treatment-resistant depression. The update notes the study's compl…
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CLINICAL_TRIALS trial_result · 2025-06-10Clinical Trial Update: Antidepressant Effects of TS-161 in Treatment-Resistant Depression [Phase 2]
The Phase 2 study of TS-161 for treatment-resistant depression was terminated, and trial results have been posted.
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: A Trial of GH001 in Patients With Treatment-resistant Depression [Phase 2]
GH Research Ireland Limited has completed a Phase 2 trial evaluating GH001 in patients with treatment-resistant depression.
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: Combining rTMS and tDCS in Depression: an Exploratory Clinical Trial [NA]
An exploratory trial evaluating combined rTMS and tDCS for major depressive disorder, including treatment-resistant depression, has been ter…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: A Biomarker-Guided, Randomized, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With TRD [Phase 2]
A biomarker-guided, randomized, placebo-controlled Phase 2 trial evaluating Liafensine for treatment-resistant depression has completed, wit…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: Treatment-Resistant Depression Cohort in Europe
A European treatment-resistant depression cohort trial sponsored by Janssen-Cilag Ltd has been completed, per ClinicalTrials.gov update.
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: Treatment Resistant Depression in America Latina
This clinical trial update reports that a Janssen-sponsored study on treatment-resistant depression conducted in Latin America has reached c…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: An Epidemiology Study of Treatment Resistant Depression in the United States (US)
This is a completed epidemiology study in the United States examining treatment-resistant depression, sponsored by Janssen Research & Develo…
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CLINICAL_TRIALS trial_result · 2025-04-09Clinical Trial Update: Psilocybin-assisted Interpersonal Therapy for Depression [NA]
A completed clinical trial evaluated psilocybin-assisted interpersonal therapy for treatment-resistant depression.
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CLINICAL_TRIALS trial_result · 2025-03-24Clinical Trial Update: Pilot Accelerated Theta Burst in Treatment-Resistant Bipolar Depression [NA]
This update reports the completion of a pilot accelerated theta burst stimulation trial in treatment-resistant bipolar depression and notes …
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CLINICAL_TRIALS trial_result · 2025-03-12Clinical Trial Update: Intensive TMS for Bipolar Depression [NA]
An intensive transcranial magnetic stimulation (TMS) trial for bipolar depression, including treatment-resistant depression, has completed. …
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CLINICAL_TRIALS trial_result · 2025-03-05Clinical Trial Update: Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on Suicidality [NA]
Completed clinical trial evaluating ketamine for treatment-resistant major depressive disorder and its effect on suicidality.
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CLINICAL_TRIALS trial_result · 2025-03-04Clinical Trial Update: A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression [Phase 4]
Phase 4 trial evaluating Esketamine nasal spray as monotherapy in adults with treatment-resistant depression has completed, with results pos…
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CLINICAL_TRIALS trial_result · 2025-02-12Clinical Trial Update: Ketogenic Diet for Treatment-Resistant Depression: Dietary Interventions for MEntal Health Study (DIME) [NA]
The DIME study from the University of Oxford evaluating a ketogenic diet for treatment-resistant depression has completed; no efficacy resul…
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CLINICAL_TRIALS trial_result · 2024-12-20Clinical Trial Update: The RECOVER sUb-study, Which Leverages quaNtitative and Credible Research tOols From Verily, Will providE Assessment measuRes for Depressive Episodes
This clinical trial update reports that the RECOVER sub-study, which used quantitative and credible research tools from Verily to assess dep…
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CLINICAL_TRIALS trial_result · 2024-12-12Clinical Trial Update: Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant Depression [NA]
Long-term follow-up results from a terminated clinical trial evaluating deep brain stimulation for treatment-resistant depression have been …
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CLINICAL_TRIALS trial_result · 2024-12-11Clinical Trial Update: Risk-Targeted Behavioural Activation for the Management of Treatment-Resistant Depression. [NA]
A clinical trial update on risk-targeted behavioural activation for managing treatment-resistant depression. The trial status is completed.
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CLINICAL_TRIALS trial_result · 2024-11-14Clinical Trial Update: Effect of Ketamine on Neurological Activity as Measured by Electroencephalogram (EEG)
This clinical trial evaluated the effect of ketamine on brain activity measured by EEG in individuals with treatment-resistant depression. T…