Treatment-resistant Depression
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CLINICAL_TRIALS research · 2025-04-22Clinical Trial Update: Maintenance rTMS for Depression (Maitr-De) [NA]
Clinical trial update for maintenance rTMS in depression shows a recruiting study for major depressive disorder and treatment-resistant depr…
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: Open Label - Personalized Therapeutic Neuromodulation for Anhedonic Depression [NA]
An open-label clinical trial evaluating personalized therapeutic neuromodulation for treatment-resistant depression, currently active but no…
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CLINICAL_TRIALS research · 2025-03-24Clinical Trial Update: OSU6162 as add-on in SSRI/SNRI-resistant Depression [Phase 2]
A Phase 2 clinical trial evaluating OSU6162 as an add-on therapy for SSRI/SNRI-resistant depression; it is currently recruiting.
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CLINICAL_TRIALS research · 2025-03-18Clinical Trial Update: Positron Emission Tomography in Transcranial Magnetic Stimulation Intervention for Treatment-resistant Depression [NA]
An ongoing registry study at a Chinese hospital is exploring a PET-guided transcranial magnetic stimulation intervention for treatment-resis…
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CLINICAL_TRIALS research · 2025-03-18Clinical Trial Update: Comparison of Different Acceleration Modes of Transcranial Magnetic Stimulation [NA]
This entry describes a study comparing different acceleration modes of transcranial magnetic stimulation for treatment-resistant depression;…
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CLINICAL_TRIALS research · 2025-01-23Clinical Trial Update: ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression [Phase 4]
A Phase 4 clinical trial comparing electroconvulsive therapy with ketamine anesthesia versus high-dose ketamine with ECT rescue for treatmen…
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CLINICAL_TRIALS research · 2025-01-20Clinical Trial Update: Personalized DBS Targeting for Treating Depression [EARLY_Phase 1]
An early-phase 1 clinical trial is evaluating personalized deep brain stimulation targeting for treatment-resistant depression and is curren…
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CLINICAL_TRIALS research · 2024-12-24Clinical Trial Update: Neurocardiac Predictors of Treatment Response to RTMS in Depression [NA]
This clinical trial update describes a University of British Columbia study investigating neurocardiac predictors of response to repetitive …
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CLINICAL_TRIALS research · 2024-12-19Clinical Trial Update: The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression [NA]
This clinical study from Unity Health Toronto investigates how working memory tasks and reward-related brain markers influence dorsolateral …
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: Psilocybin for Hospitalized Patients with Treatment-resistant Depression [Phase 2]
A Phase 2 clinical trial tests psilocybin in hospitalized patients with treatment-resistant depression. The study is currently recruiting.
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD) [Phase 2]
An open-label Phase 2 study evaluating the safety and efficacy of psilocybin in participants with treatment-resistant depression; the trial …
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CLINICAL_TRIALS research · 2024-08-07Clinical Trial Update: Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation [NA]
A clinical trial at West China Hospital is investigating local field potential biomarkers for treatment-resistant major depression using dee…
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CLINICAL_TRIALS research · 2024-08-07Clinical Trial Update: Efficacy of Deep Brain Stimulation(DBS) for Treatment-Resistant Depression(TRD) [NA]
A clinical trial update indicates a study evaluating the efficacy of deep brain stimulation for treatment-resistant depression, currently no…
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CLINICAL_TRIALS research · 2024-07-10Clinical Trial Update: IV Ketamine vs. IN Esketamine for MDD TRD
A clinical trial comparing intravenous ketamine with intranasal esketamine for treatment-resistant depression is currently recruiting.
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CLINICAL_TRIALS research · 2024-05-21Clinical Trial Update: Glutamate Emotion Memory Study [NA]
Ongoing clinical trial at University of Oxford investigating glutamate-related treatment for treatment-resistant depression and depression; …
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CLINICAL_TRIALS research · 2024-05-07Clinical Trial Update: Neural and Antidepressant Effects of Propofol [Phase 2, Phase 3]
This is a clinical trial update on Phase 2 and Phase 3 studies evaluating the neural and antidepressant effects of propofol in treatment-res…
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CLINICAL_TRIALS research · 2024-05-07Clinical Trial Update: pBFS-guided rTMS Over DMPFC for Treatment-Resistant Depression [NA]
A clinical study is evaluating pBFS-guided repetitive transcranial magnetic stimulation over the dorsomedial prefrontal cortex for treatment…
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CLINICAL_TRIALS research · 2024-04-30Clinical Trial Update: Home-based Transcranial Direct Current Stimulation for Treatment Resistant Depression [NA]
A clinical trial is evaluating home-based transcranial direct current stimulation for treatment-resistant depression and is currently recrui…
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CLINICAL_TRIALS research · 2024-04-30Clinical Trial Update: Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder [NA]
Clinical trial evaluating accelerated intermittent theta-burst stimulation as a treatment for treatment-resistant depression in Bipolar II d…
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CLINICAL_TRIALS research · 2017-04-26Clinical Trial Update: A Clinical Evaluation of Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression [NA]
An update on a clinical evaluation of Subcallosal Cingulate Gyrus Deep Brain Stimulation for treatment-resistant depression, sponsored by Ab…
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CLINICAL_TRIALS research · 2016-09-21Clinical Trial Update: Clinical Trial of the Use of Ketamine in Treatment Resistant Depression [Phase 4]
This entry notes a Phase 4 clinical trial evaluating ketamine for treatment-resistant depression, with the trial status currently unknown.
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CLINICAL_TRIALS research · 2016-07-28Clinical Trial Update: Inflammatory Markers and Resistant Depression [NA]
This clinical trial update examines inflammatory markers in major depressive disorder and treatment-resistant depression, with the trial sta…
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CLINICAL_TRIALS research · 2016-04-06Clinical Trial Update: Focal Electrically Administered Seizure Therapy for the Treatment of Depression [NA]
Update on a clinical trial evaluating focal electrically administered seizure therapy for treatment-resistant depression; current status of …
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CLINICAL_TRIALS research · 2013-08-13Clinical Trial Update: Functional and Neurochemical Correlates of Treatment Response in Major Depressive Disorder
This terminated clinical trial explored functional and neurochemical correlates of treatment response in major depressive disorder with trea…
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CLINICAL_TRIALS research · 2013-07-11Clinical Trial Update: Interpersonal Psychotherapy for Treatment Resistant Depression [NA]
This clinical trial update concerns interpersonal psychotherapy for treatment-resistant depression. The current status is unknown and no res…