Treatment-resistant Depression
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Psilocybin Microdosing With Psychotherapy for Treatment-Resistant Depression [Phase 2]
Phase 2 trial evaluating psilocybin microdosing with psychotherapy for treatment-resistant depression; recruitment is ongoing at Beersheva M…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Transcranial Magnetic Stimulation for Treatment Resistant Depression [Phase 2, Phase 3]
Clinical trial update describing a randomized, double-blind comparison of NRX-101 vs placebo for adults with treatment-resistant depression,…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression [Phase 3]
Phase 3 clinical trial evaluating psilocybin for treatment-resistant major depression in veterans is not yet recruiting.
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CLINICAL_TRIALS research · 2025-11-05Clinical Trial Update: Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI [NA]
A clinical trial evaluating cortical inhibition as a biomarker of response in a comparison of bilateral versus unilateral accelerated theta …
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CLINICAL_TRIALS research · 2025-10-27Clinical Trial Update: Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing [NA]
A Baylor College of Medicine clinical trial is recruiting to map and modulate the spatiotemporal dynamics of socio-affective processing in t…
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CLINICAL_TRIALS research · 2025-10-14Clinical Trial Update: Intravenous Ketamine for Treatment-Resistant Depression [Phase 2]
Phase 2 clinical trial evaluating intravenous ketamine for treatment-resistant depression is currently recruiting.
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ) [Phase 2]
A Phase 2 randomized proof-of-concept study evaluating the efficacy of a psilocybin and trazodone combination for treatment-resistant depres…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Mental Health Mission Mood Disorder Cohort Study
Clinical trial update from the University of Oxford for a mood disorder cohort study. The trial is currently not recruiting and covers major…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression [NA]
A clinical trial update describes an NCT06511544 study evaluating repetitive transcranial magnetic stimulation (rTMS) to improve neural conn…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. [Phase 3]
A Phase 3 clinical trial is examining whether a six-week intensified pharmacological treatment improves outcomes in adults with major depres…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Randomized Controlled Trial Testing the Efficacy of Transcranial Magnetic Stimulation by Accelerated & High-dose Theta-burst, Functional Imaging Guided, in the Treatment of Depression in Elderly Subjects With Cognitive Impairment [NA]
A randomized controlled trial is testing accelerated, high-dose theta-burst transcranial magnetic stimulation guided by functional imaging f…
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CLINICAL_TRIALS research · 2025-08-11Clinical Trial Update: Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression [NA]
A clinical trial is evaluating focused ultrasound neuromodulation as a treatment for treatment-resistant depression and is currently recruit…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Ketamine Augmentation of ECT in Treatment-Resistant Depression [Phase 3]
Phase 3 study evaluating ketamine augmentation of electroconvulsive therapy for treatment-resistant major depressive disorder is currently r…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression [Phase 4]
Phase 4 clinical trial comparing algorithm-guided treatment to treatment as usual for treatment-resistant depression; status is not yet recr…
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CLINICAL_TRIALS research · 2025-07-18Clinical Trial Update: Deep Brain Stimulation for Treatment Resistant Depression With the Medtronic Activa PC+S [NA]
Clinical trial update for deep brain stimulation using the Medtronic Activa PC+S in treatment-resistant depression; the study is currently a…
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CLINICAL_TRIALS research · 2025-07-02Clinical Trial Update: Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression [NA]
The document describes a recruiting clinical study evaluating tractography-guided subcallosal cingulate deep brain stimulation for treatment…
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CLINICAL_TRIALS research · 2025-06-17Clinical Trial Update: Accelerated Transcranial Magnetic Stimulation in Treatment-Resistant Depressed Patients [NA]
A clinical trial update from Ataturk University shows an accelerated, sham-controlled bilateral repetitive transcranial magnetic stimulation…
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression [Phase 4]
A Phase 4 comparative effectiveness study examining two forms of ketamine for treatment-resistant depression is currently recruiting.
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CLINICAL_TRIALS research · 2025-05-22Clinical Trial Update: Treatment Resistant Depression and Vagus Nerve Stimulation [NA]
Clinical trial update indicates a study evaluating vagus nerve stimulation for treatment-resistant depression is currently recruiting.
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CLINICAL_TRIALS research · 2025-05-13Clinical Trial Update: Adjuvant Accelerated piTBS for Reducing Suicidal Ideation in TRD Patients [NA]
Clinical trial update on an adjuvant accelerated piTBS approach to reduce suicidal ideation in patients with treatment-resistant major depre…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Maintenance TMS in Treatment Resistant Depression [NA]
A clinical trial is currently recruiting to evaluate maintenance transcranial magnetic stimulation for treatment-resistant depression.
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST) [Phase 2]
Phase 2 clinical trial investigating imaging the effects of a serotonin 2A receptor modulator on synaptic density in treatment-resistant dep…
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CLINICAL_TRIALS research · 2025-05-01Clinical Trial Update: Deciphering Principles of Network Dynamics Underlying Depression Symptom Severity From Multi-day Intracranial Recordings in Patients With Major Depression
This completed clinical trial studies how brain network dynamics, measured via multi-day intracranial recordings, relate to depression sympt…
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: Physical Activity Program for TRD [NA]
Clinical trial investigating a physical activity program for treatment-resistant depression and major depressive disorder; currently recruit…
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CLINICAL_TRIALS research · 2025-04-25Clinical Trial Update: Does Psilocybin Require Psychedelic Effects to Treat Depression? [Phase 2]
A Phase 2 clinical trial is exploring whether psilocybin's psychedelic effects are necessary to treat treatment-resistant depression, and th…