Treatment-resistant Depression
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression [NA]
Clinical trial update on deep brain stimulation therapy for treatment-resistant depression, with status active but not recruiting.
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: DBS for TRD With the Medtronic Summit RC+S [NA]
This clinical trial update reports that a deep brain stimulation approach using the Medtronic Summit RC+S for treatment-resistant depression…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: DBS for TRD With the Medtronic Percept PC [NA]
A clinical trial update shows recruitment is ongoing for a deep brain stimulation study using the Medtronic Percept PC to treat treatment-re…
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CLINICAL_TRIALS research · 2026-02-06Clinical Trial Update: Dopaminergic Dysfunction in Late-Life Depression [Phase 2]
A Phase 2 clinical trial from Vanderbilt University Medical Center is investigating dopaminergic dysfunction in late-life depression and its…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Ketogenic Diet and Neuromodulation in Treatment Resistant Depression [NA]
A Sunnybrook Health Sciences Centre trial is evaluating a ketogenic diet combined with neuromodulation for treatment-resistant major depress…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA) [Phase 2]
Phase 2 trial ongoing to evaluate the efficacy, safety, and tolerability of VLS-01 Buccal Film versus placebo in treatment-resistant depress…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression [NA]
A clinical trial is evaluating accelerated versus conventional theta burst stimulation for late-life depression and is currently recruiting.
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: Esketamine With or Without Integration Therapy for Treatment-Resistant Depression [Phase 4]
A Phase 4 clinical trial is evaluating esketamine with or without integration therapy for treatment-resistant depression and is currently re…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression [NA]
A prospective, multi-center randomized blinded trial evaluating the safety and effectiveness of the VNS Therapy System as adjunctive therapy…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: COpenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for Treatment Resistant Depression [NA]
A clinical trial update for Copenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for treating treatment-resistant depression, …
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Psilocybin for Treatment-Resistant Depression [Phase 2]
Phase 2 clinical trial update on psilocybin for treatment-resistant major depressive disorder; the study is currently active but not recruit…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: DBS for Depression [Phase 1]
A Phase 1 clinical trial sponsored by Northwell Health evaluating deep brain stimulation for treatment-resistant depression is currently rec…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Compressed Intermittent Theta Burst Stimulation [NA]
University of Pennsylvania is conducting a clinical trial on compressed intermittent theta burst stimulation for treatment-resistant depress…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Antidepressant Effects of Nitrous Oxide [Phase 2]
Phase 2 clinical trial evaluating the antidepressant effects of nitrous oxide in major depressive disorder and treatment-resistant depressio…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Neuronavigated aiTBS for TRD [NA]
This clinical trial entry describes neuronavigated accelerated intermittent theta-burst stimulation (aiTBS) for treatment-resistant depressi…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression [NA]
A clinical trial evaluating whether adding transcranial magnetic stimulation to electroconvulsive therapy for treatment-resistant depression…
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CLINICAL_TRIALS research · 2025-12-31Clinical Trial Update: CET- REM (Correlating ECT Response to EEG Markers) [NA]
The CET-REM study investigates whether EEG markers correlate with electroconvulsive therapy response in treatment-resistant depression, and …
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement [NA]
This document provides a protocol supplement for a vagus nerve stimulation (VNS) study in treatment-resistant depression, outlining EEG meth…
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: Ketamine Biomarker Validation [Phase 1]
A Phase 1 trial from Soterix Medical is validating ketamine biomarkers for treatment-resistant depression and is not yet recruiting.
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Parcel-guided rTMS for Major Depressive Disorder [Phase 2]
Phase 2 clinical trial update on parcel-guided rTMS by Soterix Medical for major depressive disorder with treatment-resistant depression; th…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression [NA]
ClinicalTrials.gov update describing a feasibility study evaluating whether exercise can prime response to repetitive transcranial magnetic …
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Sustained Mood Improvement With Laughing Gas Exposure [Phase 3]
A Phase 3 clinical trial sponsored by Women's College Hospital is investigating nitrous oxide exposure for sustained mood improvement in maj…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Comparison of the Efficacy of Accelerated Intermittent Theta Burst Stimulation and Accelerated Continuous Theta Burst Stimulation in Patients With Treatment-Resistant Depression [NA]
Status update for a clinical trial comparing accelerated intermittent theta burst stimulation and accelerated continuous theta burst stimula…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: An Open-Label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant Depression [Phase 2]
Open-label Phase 2 study to evaluate the safety, tolerability, and pharmacodynamics of BPL-003 in patients with treatment-resistant depressi…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Psilocybin rTMS for Treatment Resistant Depression [Phase 2]
A Phase 2 clinical trial at the University of Texas at Austin is testing psilocybin-assisted rTMS for treatment-resistant depression and is …