Transthyretin Amyloidosis
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis
This clinical trial update describes the OverTTuRe study on characteristics, treatment patterns, and outcomes in patients with transthyretin…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: NatiOnal Referral cenTEr Study of Transthyretin Amyloid Cardiomyopathy(ATTR) Patients on Tafamidis
A clinical trial at a national referral center is evaluating tafamidis in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) and i…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Implementation of Standardized Early Identification and Diagnosis for Transthyretin Amyloidosis (ATTR) in High-Risk Populations [NA]
AstraZeneca is implementing standardized early identification and diagnosis strategies for transthyretin amyloidosis in high-risk population…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis [Phase 2]
A Phase 2 clinical trial update characterizing iodine-124 labeled Evuzumitide (AT-01) for systemic amyloidosis, including transthyretin amyl…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Association Between Lifetime Physical Activity and Exercise and the Development of Wild-type Transthyretin Amyloid Cardiomyopathy
This update describes a completed clinical trial examining whether lifetime physical activity and exercise influence the risk of developing …
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: The Eplontersen Pregnancy and Lactation Outcomes Study
The Eplontersen pregnancy and lactation outcomes study (NCT07205666) sponsored by AstraZeneca is currently recruiting for transthyretin amyl…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant [Phase 3]
This entry notes that Acoramidis is being evaluated in a Phase 3 ACT-EARLY prevention trial in asymptomatic carriers of pathogenic TTR varia…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: The Italian Transthyretin Amyloidosis Web-Network
The Italian Transthyretin Amyloidosis Web-Network trial update indicates the study is currently recruiting participants.
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis
A non-interventional observational study sponsored by AstraZeneca to collect data on patients with transthyretin amyloidosis, including ATTR…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: ATTRACT-52: Primary Care Cardiac Amyloidosis Screening in Ordu, Turkey
This clinical trial update indicates that ATTRACT-52, a study screening for cardiac amyloidosis due to transthyretin amyloidosis in primary …
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Spectrum of Peripheral and Autonomic Neuropathies in Patients With aTTRwt Amyloidosis and Response to Patisiran Therapy [EARLY_Phase 1]
An early-phase clinical trial update describing peripheral and autonomic neuropathies in wild-type transthyretin amyloidosis and response to…
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CLINICAL_TRIALS research · 2026-01-05Clinical Trial Update: Myocardial Effects in Patients With ATTRv With Polyneuropathy Treated With Patisiran or Vutrisiran
Clinical trial update describing myocardial effects observed in patients with hereditary transthyretin-mediated amyloidosis with polyneuropa…
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: ATTR Amyloid Cardiomyopathy: Characterization of Extracellular Vesicles as Potential Disease Stratifiers and Prognostic Biomarkers
This clinical trial update describes a study on extracellular vesicles as potential disease stratifiers and prognostic biomarkers for transt…
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Efficacy of [18F]Florbetaben PET for Diagnosis of Cardiac AL Amyloidosis [Phase 3]
This Clinical Trial Update describes a Phase 3 study evaluating the efficacy of the PET tracer Florbetaben (18F) for diagnosing cardiac AL a…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
A Columbia University-led clinical trial is recruiting to analyze lumbar spine stenosis specimens for identification of transthyretin-relate…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: Phenotyping and Characterization of wtATTR-CM (TRACE 1)
Clinical trial TRACE 1 is a recruiting study that aims to phenotype and characterize wild-type transthyretin amyloid cardiomyopathy in trans…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Validation of a Questionnaire for Quality of Life Assessment in Patients With Transthyretin Amyloidosis.
A clinical trial update describes validation of a quality-of-life questionnaire for patients with transthyretin amyloidosis to support futur…
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Prevalence of Wild-type TTR Cardiac Amyloidosis in Patients With Polyneuropathy of Unknown Cause. [NA]
A clinical trial evaluating how prevalent wild-type transthyretin cardiac amyloidosis is among patients with polyneuropathy of unknown cause…
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CLINICAL_TRIALS research · 2025-06-29Clinical Trial Update: TRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positive Subjects
This clinical trial update describes the TRAMmoniTTR study, a genetic screening program for individuals at risk of hereditary transthyretin …
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CLINICAL_TRIALS research · 2025-04-10Clinical Trial Update: Retrospective Identification of Scintigraphic Cardiac Amyloidosis (RISCA)
The document announces a retrospective study (RISCA) intended to identify scintigraphic cardiac amyloidosis. Sponsored by University Hospita…
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CLINICAL_TRIALS research · 2025-01-31Clinical Trial Update: Quantitative Analysis of Myocardial Uptake of Bone Radiopharmaceuticals in Patients With Cardiac ATTR Amyloidosis [NA]
An ongoing clinical trial is evaluating quantitative myocardial uptake of bone radiopharmaceuticals in patients with transthyretin-related c…
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CLINICAL_TRIALS research · 2024-12-09Clinical Trial Update: Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF [NA]
A Massachusetts General Hospital study is recruiting to assess how common transthyretin amyloidosis is and how to predict its presence in am…
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CLINICAL_TRIALS research · 2024-12-03Clinical Trial Update: PL_GNT01_ISR_Grant 53234273
A clinical trial update indicates that the PL_GNT01_ISR_Grant study (NCT06714019) is currently enrolling by invitation for transthyretin-rel…
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CLINICAL_TRIALS research · 2024-10-23Clinical Trial Update: Prevalence and Significance of ATTR Aortic Valve Amyloidosis in Degenerative Aortic Stenosis [NA]
This trial investigates the prevalence and clinical significance of transthyretin (ATTR) amyloidosis of the aortic valve in patients with de…