Therapy-related Acute Myeloid Leukemia
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial) [Phase 2]
This is a Phase 2 screening trial (MYELOMATCH) sponsored by the National Cancer Institute to assign people with myeloid cancers to a treatme…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Bortezomib, Sorafenib Tosylate, and Decitabine in Treating Patients With Acute Myeloid Leukemia [Phase 1]
Phase 1 clinical trial evaluating a three-drug combination (bortezomib, sorafenib tosylate, and decitabine) in adults with acute myeloid leu…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Use of Combination Therapy in Patients With Persistent Low Level Acute Myeloid Leukemia Following Initial Treatment, The ERASE Study (A MyeloMATCH Treatment Trial) [Phase 2]
Phase 2 ERASE trial update exploring combination therapy for persistent low-level acute myeloid leukemia after initial treatment; the study …
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study [Phase 1, Phase 2]
PedAL BCU, LLC is conducting a pediatric screening trial to test bone marrow and blood methods in children with relapsed or hard-to-treat ac…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: CPX-351 and Glasdegib for Newly Diagnosed Acute Myelogenous Leukemia With MDS Related Changes or Therapy-related Acute Myeloid Leukemia [Phase 2]
Phase 2 trial update evaluating CPX-351 in combination with glasdegib for newly diagnosed acute myeloid leukemia with myelodysplasia-related…
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: Venetoclax and Azacitidine for the Treatment of Acute Myeloid Leukemia in the Post-Transplant Setting [Phase 2]
This clinical trial update describes a Phase 2 study of venetoclax plus azacitidine for acute myeloid leukemia in the post-transplant settin…
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CLINICAL_TRIALS trial_result · 2026-03-04Clinical Trial Update: BLAST MRD AML-1: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Intensive Chemotherapy as Frontline Therapy in Patients With Acute Myeloid Leukemia [Phase 2]
A randomized Phase 2 trial (BLAST MRD AML-1) evaluates adding pembrolizumab to intensive chemotherapy as frontline therapy for acute myeloid…
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CLINICAL_TRIALS trial_result · 2025-12-23Clinical Trial Update: CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old [Phase 2]
Phase 2 trial update of CPX-351 for secondary acute myeloid leukemia in patients under 60; the study is currently active but not recruiting,…
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes [Phase 2]
Phase 2 trial evaluating adding pomalidomide to the standard liposomal daunorubicin/cytarabine chemotherapy in newly diagnosed acute myeloid…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Pevonedistat, Cytarabine, and Idarubicin in Treating Patients With Acute Myeloid Leukemia [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating pevonedistat with cytarabine and idarubicin for various forms of acute myeloid leukemia, including thera…
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: VYxeoS Liposomal Italian Observational Study iN the Real Practice
A real-world observational study in Italy evaluating Vyxeos (CPX-351) for acute myeloid leukemia and its subtypes has completed.
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CLINICAL_TRIALS trial_result · 2025-11-05Clinical Trial Update: Geriatric Assessment & Genetic Profiling to Personalize Therapy in Older Adults With Acute Myeloid Leukemia [Phase 2]
Phase 2 trial evaluating geriatric assessment and genetic profiling to personalize therapy for older adults with acute myeloid leukemia; the…
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CLINICAL_TRIALS trial_result · 2025-09-08Clinical Trial Update: PF-05212384 (PKI-587) for t-AML/MDS or de Novo Relapsed or Refractory Acute Myeloid Leukemia (AML) (LAM-PIK) [Phase 2]
Phase 2 trial of PF-05212384 (PKI-587) for therapy-related AML/MDS and de novo/relapsed or refractory AML was terminated. The update indicat…
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation [Phase 2]
Phase 2 trial evaluating olaparib for relapsed/refractory IDH-mutated acute myeloid leukemia or myelodysplastic syndrome; results posted 202…
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CLINICAL_TRIALS trial_result · 2024-11-04Clinical Trial Update: Nivolumab and Azacitidine With or Without Ipilimumab in Treating Patients With Refractory/Relapsed or Newly Diagnosed Acute Myeloid Leukemia [Phase 2]
Phase 2 trial testing nivolumab and azacitidine with or without ipilimumab for refractory/relapsed or newly diagnosed acute myeloid leukemia…
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CLINICAL_TRIALS trial_result · 2023-11-07Clinical Trial Update: Donor Natural Killer Cells and Donor Stem Cell Transplant in Treating Patients With High Risk Myeloid Malignancies [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating donor natural killer cells and donor stem cell transplant in high-risk myeloid malignancies; completed w…
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FDA approval · 2022-09-27FDA Approved: VYXEOS — Supplemental Application (Jazz Pharmaceuticals, Inc.)
The FDA approved a supplemental application for VYXEOS (daunorubicin and cytarabine liposome) from Jazz Pharmaceuticals, Inc. This action re…
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CLINICAL_TRIALS trial_result · 2020-06-09Clinical Trial Update: Vosaroxin and Infusional Cytarabine in Treating Patients With Untreated Acute Myeloid Leukemia [Phase 2]
Phase 2 clinical trial update evaluating vosaroxin with infusional cytarabine for untreated acute myeloid leukemia; results have been posted…
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FDA approval · 2017-08-03FDA Approved: VYXEOS — Original Application (Jazz Pharmaceuticals, Inc.)
FDA granted original approval for VYXEOS (daunorubicin and cytarabine liposome) for adults with therapy-related acute myeloid leukemia or ac…
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CLINICAL_TRIALS trial_result · 2016-10-24Clinical Trial Update: Decitabine With or Without Bortezomib in Treating Older Patients With Acute Myeloid Leukemia [Phase 2]
Phase 2 trial evaluating decitabine with or without bortezomib in older adults with acute myeloid leukemia; study completed with results pos…
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CLINICAL_TRIALS trial_result · 2014-08-12Clinical Trial Update: Combination Chemotherapy and Dasatinib in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia [Phase 2]
Phase 2 clinical trial assessing combination chemotherapy with dasatinib for newly diagnosed acute myeloid leukemia; completed with results …