Systemic Lupus Erythematosus
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: A Study of APG-2575 in Patients With Mild-to-moderate Systemic Lupus Erythematosus. [Phase 1, Phase 2]
APG-2575 is being studied in Phase 1 and Phase 2 trials for mild-to-moderate systemic lupus erythematosus, with recruitment ongoing.
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: EG-501 for Cognitive Impairment in Neuropsychiatric SLE (NPSLE): Efficacy and Safety Study [Phase 2]
Phase 2 study of EG-501 in cognitive impairment associated with neuropsychiatric lupus has completed, evaluating efficacy and safety.
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Subcutaneous Injections of SHR-2173 in Patients With Systemic Lupus Erythematosus [Phase 1]
Phase I clinical study evaluating safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple subcutaneous injections of SHR-21…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: REACT-01: Reversing Autoimmunity Through Cell Therapy [Phase 1]
A Phase 1 clinical trial, REACT-01, is evaluating a cell therapy approach to reversing autoimmunity in systemic lupus erythematosus and is c…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: The RheumSafer Study: Improving Medication Appropriateness in People With Rheumatic Conditions
This update describes the RheumSafer Study, a clinical trial aimed at improving medication appropriateness for people with rheumatic conditi…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Clinical and Demographic Features of Patients With Moderate to Severe Active Systemic Lupus Erythematosus in Russia
Clinical trial update describing the clinical and demographic features of patients with moderate-to-severe active systemic lupus erythematos…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Allogeneic UCB-derived CAR-T for SLE [EARLY_Phase 1]
An early-phase (Phase 1) clinical trial evaluating an allogeneic umbilical cord blood-derived CAR-T therapy for systemic lupus erythematosus…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: AB-101 in Combination With B-Cell Depleting mAb in Patients Who Failed Treatment for Class III or IV Lupus Nephritis or Other Forms of Refractory Systemic Lupus Erythematosus [Phase 1]
This Phase 1 clinical trial update shows AB-101, in combination with a B-cell depleting monoclonal antibody, is being studied in lupus nephr…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Brief Pain Exposure Therapy (BPET) For Nociplastic Pain [NA]
ClinicalTrials.gov update shows University of Michigan recruiting for a Brief Pain Exposure Therapy study targeting nociplastic pain in fibr…
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CLINICAL_TRIALS trial_result · 2025-12-08Clinical Trial Update: A Study of Nipocalimab in Adult Participants With Active Systemic Lupus Erythematosus [Phase 2]
A Phase 2 study evaluating Nipocalimab in adults with active systemic lupus erythematosus has completed.
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: CD19/BCMA CAR-T for SLE [EARLY_Phase 1]
An early-phase 1 clinical trial evaluates a CD19/BCMA CAR-T therapy for systemic lupus erythematosus (SLE). The study is currently not yet r…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease [Phase 2]
Phase 2 two-period crossover study to demonstrate pharmacokinetic comparability of subcutaneous ianalumab administered with a 2 mL auto-inje…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Characterization of Autoreactive b Lymphocytes in Autoimmune Diseases and Immune Deficiencies
This clinical trial aims to characterize autoreactive B lymphocytes in autoimmune diseases and immune deficiencies. The study status is not …
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Interferon Signature in Anti-CTLA-4 and Anti-PD-1/PD-L1-Treated Cancer Patients Compared With Systemic Autoimmune Disease Patients
A recruiting clinical trial examining interferon signature differences between cancer patients treated with anti-CTLA-4 or anti-PD-1/PD-L1 t…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE) [Phase 3]
A Phase 3 study compares deucravacitinib to placebo in active systemic lupus erythematosus. The trial is currently active but not recruiting…
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases [Phase 4]
Phase 4 clinical trial update on the recombinant herpes zoster vaccine in patients with autoimmune rheumatic diseases; the study is active b…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Ferroptosis Role in the Pathophysiology of Systemic Lupus Erythematosus [NA]
This clinical trial update describes research into the role of ferroptosis in the pathophysiology of systemic lupus erythematosus, led by Un…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: A Study to Evaluate Effectiveness and Safety of Deucravacitinib (BMS-986165) Compared With Placebo in Participants With Active Systemic Lupus Erythematosus [Phase 3]
A Phase 3 clinical trial is evaluating the effectiveness and safety of deucravacitinib (BMS-986165) versus placebo in adults with active sys…
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CLINICAL_TRIALS trial_result · 2025-12-02Clinical Trial Update: Water-based Liuzijue Exercise on Childhood-onset Systemic Lupus Erythematosus [NA]
A completed clinical trial evaluating the effects of water-based Liuzijue exercise on childhood-onset systemic lupus erythematosus.
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CLINICAL_TRIALS trial_result · 2025-12-01Clinical Trial Update: The WILLOW Study With M5049 in SLE and CLE (SCLE and/or DLE) (WILLOW) [Phase 2]
The WILLOW Phase 2 study evaluated M5049 in systemic lupus erythematosus with cutaneous lupus erythematosus (SCLE/DLE) and has completed wit…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Anti-CD19/BCMA CAR-NK Cells in Patients With B Cell Mediated Autoimmune Disease [EARLY_Phase 1]
Update on an early-phase trial of anti-CD19/BCMA CAR-NK cells for B cell–mediated autoimmune diseases, with recruitment ongoing.
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CLINICAL_TRIALS trial_result · 2025-12-01Clinical Trial Update: Vagus Nerve Stimulation for Fatigue in Systemic Lupus [NA]
A completed clinical trial evaluated vagus nerve stimulation as a treatment for fatigue in systemic lupus erythematosus.
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: A Phase II Clinical Study on the Efficacy and Safety of SHR-2173 Injection in the Treatment of Patients With Active Lupus Nephritis [Phase 2]
A Phase II clinical study evaluating the efficacy and safety of SHR-2173 injection for active lupus nephritis, with recruitment currently on…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Blinatumomab in Refractory Active Childhood Systemic Lupus Erythematosus [Phase 1]
Phase 1 clinical trial evaluating the safety and preliminary efficacy of blinatumomab in children with refractory active systemic lupus eryt…
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CLINICAL_TRIALS trial_result · 2025-11-26Clinical Trial Update: A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE) [Phase 4]
A Phase 4 clinical trial is evaluating the efficacy and safety of belimumab in adult participants with early systemic lupus erythematosus an…