Systemic Lupus Erythematosus
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CLINICAL_TRIALS trial_result · 2026-08-10Clinical Trial Results: Efficacy and Safety of MK-6194 in Adult Participants With Systemic Lupus Erythematosus (MK-6194-006) [Phase 2]
Phase 2 trial results for MK-6194 in adults with systemic lupus erythematosus were terminated with results posted.
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EMA approval · 2026-07-16EMA Authorised: Benlysta (belimumab) — GlaxoSmithKline Trading Services Limited
EMA authorised Benlysta (belimumab) for systemic lupus erythematosus.
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EMA approval · 2026-07-15EMA Authorised: Saphnelo (anifrolumab) — AstraZeneca AB
EMA has authorised Saphnelo (anifrolumab) for systemic lupus erythematosus in Europe.
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CLINICAL_TRIALS trial_result · 2026-07-08Clinical Trial Results: Using the Cholinergic Anti-Inflammatory Pathway to Treat Systemic Lupus Musculoskeletal Pain [NA]
Completed clinical trial investigating cholinergic anti-inflammatory pathway to treat systemic lupus erythematosus–related musculoskeletal p…
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CLINICAL_TRIALS trial_result · 2026-06-03Clinical Trial Update: Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2) [Phase 3]
Phase 3 trial evaluating ianalumab added to standard-of-care in systemic lupus erythematosus (SIRIUS-SLE 2) is active/not recruiting.
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CLINICAL_TRIALS trial_result · 2026-06-03Clinical Trial Update: Phase 3 Study to Evaluate Two Regimens of Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 1) [Phase 3]
Phase 3 trial update evaluating two regimens of ianalumab on top of standard therapy in systemic lupus erythematosus (SIRIUS-SLE 1).
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CLINICAL_TRIALS trial_result · 2026-04-28Clinical Trial Update: Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus [Phase 3]
Phase 3 trial update investigating adverse events and disease activity changes with oral upadacitinib in adults with moderate to severe syst…
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease [Phase 3]
Phase 3 study of enpatoran in participants with cutaneous lupus manifestations with or without systemic lupus erythematosus is currently rec…
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2) [Phase 3]
Phase 3 clinical trial of enpatoran in participants with cutaneous manifestations of lupus (with or without systemic disease) is currently r…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Study of Families With Twins or Siblings Discordant for Rheumatic Disorders
A completed clinical trial studying families with twins or siblings discordant for rheumatic disorders, conducted by NIEHS. The study includ…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Treatment of Systemic Lupus Erythematosus (SLE) With N-acetylcysteine [Phase 2]
A Phase 2 trial is evaluating N-acetylcysteine for systemic lupus erythematosus. The study status is active but not recruiting.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study of D-2570 in Patients With Active Systemic Lupus Erythematosus (SLE) [Phase 2]
A Phase 2 clinical trial evaluating D-2570 for active systemic lupus erythematosus is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Evaluating the Safety and Tolerability of Baricitinib in Patients With Job Syndrome With Lupus-Like Disease and/or Atopic Dermatitis [Phase 1]
This clinical trial update reports on evaluating the safety and tolerability of baricitinib in patients with Hyper-IgE syndrome due to STAT3…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Study to Evaluate the Safety, Tolerability, Cellular Kinetics, Pharmacodynamics, and Efficacy of P-CD19CD20-ALLO1 in Participants With Severe, Treatment-refractory Systemic Lupus Erythematosus (SLE) [Phase 1]
Phase 1 clinical trial evaluating the safety, tolerability, cellular kinetics, pharmacodynamics, and efficacy of the cellular therapy P-CD19…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Anifrolumab Malignancy and Serious Infections Study
AstraZeneca is recruiting for a clinical study of Anifrolumab in systemic lupus erythematosus, with monitoring for malignancy and serious in…
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CLINICAL_TRIALS trial_result · 2026-04-22Clinical Trial Update: Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus [Phase 2]
Phase 2 clinical trial evaluating memantine for cognitive impairment in patients with systemic lupus erythematosus has been completed.
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CLINICAL_TRIALS trial_result · 2026-04-22Clinical Trial Update: Long-Term Organ Damage: Anifrolumab Versus Real-World Standard of Care in Adult Patients With Active Systemic Lupus Erythematosus
A completed trial compares anifrolumab to real-world standard of care in adults with active systemic lupus erythematosus, focusing on long-t…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Study Investigating the Safety of Anti-CD19 CAR-T Cells Therapy Produced at Gustave Roussy for Adults With Severe and Refractory Systemic Autoimmune Rheumatic Diseases [Phase 1]
Phase 1 clinical trial evaluating the safety of CD19-targeted CAR-T cell therapy produced at Gustave Roussy for adults with severe and refra…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE) [Phase 2]
This clinical trial update notes a Phase 2 study to evaluate different doses of BI 3000202 in people with systemic lupus erythematosus, whic…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Subclinical Atherosclerosis in Juvenile Systemic Lupus Erythematosus
A ClinicalTrials.gov listing for a study on subclinical atherosclerosis in juvenile systemic lupus erythematosus, currently not recruiting.
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO [Phase 1]
Phase 1 trial evaluating nivolumab in patients with autoimmune disorders and advanced cancers; the study is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Alnuctamab for Refractory SLE (LATTE Study) [Phase 1]
A Phase 1 LATTE study evaluating alnuctamab for refractory systemic lupus erythematosus is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: A Study of NKX019, a CD19 CAR NK Cell Therapy, in Subjects With Systemic Lupus Erythematosus [Phase 1]
This clinical trial update reports a Phase 1 study of NKX019, a CD19 CAR-NK cell therapy, for Systemic Lupus Erythematosus, which has been s…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: INTERSTELLAR - International Study Evaluating Lupus Outcomes After Anifrolumab Real World Use
A real-world evidence study (INTERSTELLAR) evaluating lupus outcomes in patients treated with anifrolumab, sponsored by AstraZeneca.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Clinica Study of SCTC21C in Participants With Systemic Lupus Erythematosus [Phase 1, Phase 2]
Clinical trial entry for SCTC21C in systemic lupus erythematosus, a Phase 1/2 study that is not yet recruiting.