Systemic Lupus Erythematosus
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: A Phase 2 Clinical Study of MIL62 in Systemic Lupus Erythematosus [Phase 2]
Phase 2 clinical study of MIL62 for Systemic Lupus Erythematosus, conducted by Beijing Mabworks Biotech Co., Ltd., currently listed as activ…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Myocardial Inflammation in Systemic Lupus Erythematosus
ClinicalTrials.gov reports an update on a study examining myocardial inflammation in patients with systemic lupus erythematosus. The trial i…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: This Project Aims to Understand the Needs of Rheumatologists and Other Specialties in the Care of Patients With SLE
This completed clinical trial conducted by AstraZeneca aimed to understand the needs of rheumatologists and other specialties in caring for …
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: A Study of APG-2575 in Patients With Mild-to-moderate Systemic Lupus Erythematosus. [Phase 1, Phase 2]
APG-2575 is being studied in Phase 1 and Phase 2 trials for mild-to-moderate systemic lupus erythematosus, with recruitment ongoing.
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: REACT-01: Reversing Autoimmunity Through Cell Therapy [Phase 1]
A Phase 1 clinical trial, REACT-01, is evaluating a cell therapy approach to reversing autoimmunity in systemic lupus erythematosus and is c…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: The RheumSafer Study: Improving Medication Appropriateness in People With Rheumatic Conditions
This update describes the RheumSafer Study, a clinical trial aimed at improving medication appropriateness for people with rheumatic conditi…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Clinical and Demographic Features of Patients With Moderate to Severe Active Systemic Lupus Erythematosus in Russia
Clinical trial update describing the clinical and demographic features of patients with moderate-to-severe active systemic lupus erythematos…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Allogeneic UCB-derived CAR-T for SLE [EARLY_Phase 1]
An early-phase (Phase 1) clinical trial evaluating an allogeneic umbilical cord blood-derived CAR-T therapy for systemic lupus erythematosus…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: AB-101 in Combination With B-Cell Depleting mAb in Patients Who Failed Treatment for Class III or IV Lupus Nephritis or Other Forms of Refractory Systemic Lupus Erythematosus [Phase 1]
This Phase 1 clinical trial update shows AB-101, in combination with a B-cell depleting monoclonal antibody, is being studied in lupus nephr…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Brief Pain Exposure Therapy (BPET) For Nociplastic Pain [NA]
ClinicalTrials.gov update shows University of Michigan recruiting for a Brief Pain Exposure Therapy study targeting nociplastic pain in fibr…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease [Phase 2]
Phase 2 two-period crossover study to demonstrate pharmacokinetic comparability of subcutaneous ianalumab administered with a 2 mL auto-inje…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Characterization of Autoreactive b Lymphocytes in Autoimmune Diseases and Immune Deficiencies
This clinical trial aims to characterize autoreactive B lymphocytes in autoimmune diseases and immune deficiencies. The study status is not …
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Interferon Signature in Anti-CTLA-4 and Anti-PD-1/PD-L1-Treated Cancer Patients Compared With Systemic Autoimmune Disease Patients
A recruiting clinical trial examining interferon signature differences between cancer patients treated with anti-CTLA-4 or anti-PD-1/PD-L1 t…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE) [Phase 3]
A Phase 3 study compares deucravacitinib to placebo in active systemic lupus erythematosus. The trial is currently active but not recruiting…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Ferroptosis Role in the Pathophysiology of Systemic Lupus Erythematosus [NA]
This clinical trial update describes research into the role of ferroptosis in the pathophysiology of systemic lupus erythematosus, led by Un…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: A Study to Evaluate Effectiveness and Safety of Deucravacitinib (BMS-986165) Compared With Placebo in Participants With Active Systemic Lupus Erythematosus [Phase 3]
A Phase 3 clinical trial is evaluating the effectiveness and safety of deucravacitinib (BMS-986165) versus placebo in adults with active sys…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Anti-CD19/BCMA CAR-NK Cells in Patients With B Cell Mediated Autoimmune Disease [EARLY_Phase 1]
Update on an early-phase trial of anti-CD19/BCMA CAR-NK cells for B cell–mediated autoimmune diseases, with recruitment ongoing.
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: A Phase II Clinical Study on the Efficacy and Safety of SHR-2173 Injection in the Treatment of Patients With Active Lupus Nephritis [Phase 2]
A Phase II clinical study evaluating the efficacy and safety of SHR-2173 injection for active lupus nephritis, with recruitment currently on…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Blinatumomab in Refractory Active Childhood Systemic Lupus Erythematosus [Phase 1]
Phase 1 clinical trial evaluating the safety and preliminary efficacy of blinatumomab in children with refractory active systemic lupus eryt…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: The Purpose of This Study is to Evaluate the Efficacy and Safety of 626 in the Treatment of SLE [Phase 1, Phase 2]
A phase 1/2 clinical trial is evaluating the efficacy and safety of a drug named 626 for systemic lupus erythematosus. The study is currentl…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: miR-101-3p and Autotaxin in SLE Patients
This document reports a clinical study evaluating the roles of miR-101-3p and autotaxin in patients with Systemic Lupus Erythematosus, with …
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: MB-CART19.1 in Refractory SLE [Phase 1, Phase 2]
Miltenyi Biomedicine's MB-CART19.1 is being studied in Phase 1/2 trials for refractory systemic lupus erythematosus, with recruitment ongoin…
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Study Evaluating SC291 in Subjects With Severe r/r B-cell Mediated Autoimmune Diseases (GLEAM) [Phase 1]
Phase 1 clinical trial update for SC291 in severe B-cell–mediated autoimmune diseases; the study is active but not recruiting and includes s…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Induction Therapy for Lupus Nephritis With no Added Oral Steroids: A Trial Comparing Oral Corticosteroids Plus Mycophenolate Mofetil (MMF) Versus Obinutuzumab and MMF [Phase 3]
Phase 3 trial update comparing induction therapy for lupus nephritis with oral corticosteroids plus mycophenolate mofetil (MMF) versus obinu…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Safety, Efficacy and Cellular Metabolic Dynamics of ct1192 in Patients With Moderate to Severe Refractory SLE [Phase 1]
A Phase 1 clinical trial investigating the safety, efficacy, and cellular metabolic dynamics of ct1192 in adults with moderate to severe ref…