Single-ventricle Congenital Heart Disease
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CLINICAL_TRIALS trial_result · 2026-02-18Clinical Trial Update: Gut, Inflammation and Nutrition in Adult Patients After Fontan Operation
This clinical trial evaluated gut health, inflammation, and nutrition in adult patients after Fontan operation; the study is completed.
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CLINICAL_TRIALS trial_result · 2026-01-30Clinical Trial Update: PK/PD of Digoxin in Infants With SVHD [Phase 1, Phase 2]
A Duke University-led clinical trial is evaluating the pharmacokinetics and pharmacodynamics of digoxin in infants with single-ventricle con…
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CLINICAL_TRIALS trial_result · 2025-06-27Clinical Trial Update: Intramyocardial Injection of Autologous UCB-MNC During Fontan Surgery for SRV Dependent CHD [Phase 1]
Phase 1 trial evaluating intramyocardial injection of autologous umbilical cord blood mononuclear cells during Fontan surgery for single-ven…
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CLINICAL_TRIALS trial_result · 2025-02-10Clinical Trial Update: Simple Non-invasive Breathing Device to Improve Pulmonary Flow Pusatility in Single Ventricle Post Fontan [NA]
This entry reports a completed clinical trial evaluating a simple non-invasive breathing device to improve pulmonary flow pulsatility in pat…
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CLINICAL_TRIALS trial_result · 2024-08-30Clinical Trial Update: Inspiratory Training in Children After Fontan [NA]
Clinical trial update notes the completion of a study evaluating inspiratory muscle training in children after the Fontan procedure for resp…
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CLINICAL_TRIALS trial_result · 2022-03-28Clinical Trial Update: Pharmacokinetic, Pharmacodynamic, Safety, and Efficacy Study of Rivaroxaban for Thromboprophylaxis in Pediatric Participants 2 to 8 Years of Age After the Fontan Procedure [Phase 3]
Phase 3 pediatric trial evaluating rivaroxaban for thromboprophylaxis after Fontan procedure in children ages 2 to 8, assessing PK/PD, safet…
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CLINICAL_TRIALS trial_result · 2018-05-07Clinical Trial Update: The Effects of Ambrisentan on Exercise Capacity in Fontan Patients [Phase 4]
A Phase 4 trial assessed whether ambrisentan improves exercise capacity in Fontan patients with single-ventricle physiology; the study has c…
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CLINICAL_TRIALS trial_result · 2018-05-04Clinical Trial Update: The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart Disease [Phase 4]
Phase 4 trial evaluating the effect of eplerenone on markers of myocardial fibrosis in adults with congenital heart disease; the study was t…
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CLINICAL_TRIALS trial_result · 2018-04-18Clinical Trial Update: Colloid Osmotic Pressure in Patients With Fontan Circulation
This clinical trial update reports the completion of a study assessing colloid osmotic pressure in patients with Fontan circulation, a palli…
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CLINICAL_TRIALS trial_result · 2018-03-02Clinical Trial Update: A Pilot Study Investigating the Clinical Use of Tissue Engineered Vascular Grafts in Congenital Heart Surgery [Phase 1]
Phase 1 pilot study evaluating tissue-engineered vascular grafts in congenital heart surgery has completed.
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CLINICAL_TRIALS trial_result · 2017-11-14Clinical Trial Update: Improving Functional Capacity in Fontan Patients Through Inspiratory Muscle Training [NA]
A clinical trial evaluated inspiratory muscle training to improve functional capacity in Fontan patients with single-ventricle congenital he…
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CLINICAL_TRIALS trial_result · 2017-05-10Clinical Trial Update: Upright Versus Supine Exercise Testing in Fontan-palliated Patients
A completed clinical trial evaluating upright versus supine exercise testing in Fontan-palliated patients.
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CLINICAL_TRIALS trial_result · 2017-04-17Clinical Trial Update: Effect of Tadalafil on Exercise Capacity in Pediatric Fontan Patients [Phase 1]
A Phase 1 trial assessing tadalafil on exercise capacity in pediatric Fontan patients with single-ventricle physiology has completed.
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CLINICAL_TRIALS trial_result · 2015-03-25Clinical Trial Update: Liothyronine in Children With Single Ventricle Congenital Cardiac Malformations Undergoing the Fontan Procedure [Phase 1]
Phase 1 clinical trial update evaluating liothyronine in children with single-ventricle congenital heart defects undergoing the Fontan proce…
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CLINICAL_TRIALS trial_result · 2015-02-23Clinical Trial Update: Cardiopulmonary Adaptation of Short Term Exposure to High Altitude in Fontan Patients: Swiss Fontan & ALtitude COllaboratioN (FALCON) Study [NA]
A completed clinical trial (FALCON) evaluating cardiopulmonary adaptation to short-term high-altitude exposure in patients with Fontan physi…
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CLINICAL_TRIALS trial_result · 2013-10-29Clinical Trial Update: Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle Physiology
A clinical trial examining plastic bronchitis and protein-losing enteropathy in children with Fontan physiology has completed.