Single-ventricle Congenital Heart Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: WE BEAT - HEART Club Fontan Wellness Project: A Virtual Resilience Promotion and Frailty Prevention Program [NA]
The WE BEAT - HEART Club Fontan Wellness Project is a virtual resilience promotion and frailty prevention program for individuals with Fonta…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis
Boston Children's Hospital is sponsoring a study to profile extracellular vesicle microRNAs in congenital heart disease, exploring fetal–mat…
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CLINICAL_TRIALS trial_result · 2026-02-18Clinical Trial Update: Gut, Inflammation and Nutrition in Adult Patients After Fontan Operation
This clinical trial evaluated gut health, inflammation, and nutrition in adult patients after Fontan operation; the study is completed.
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CLINICAL_TRIALS trial_result · 2026-01-30Clinical Trial Update: PK/PD of Digoxin in Infants With SVHD [Phase 1, Phase 2]
A Duke University-led clinical trial is evaluating the pharmacokinetics and pharmacodynamics of digoxin in infants with single-ventricle con…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Study of Tadalafil vs. Placebo for Improving Hemodynamics and End-Organ Dysfunction in Fontan Physiology [Phase 3]
A Phase 3 trial compares tadalafil versus placebo to improve hemodynamics and end-organ function in Fontan physiology. The study is currentl…
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CLINICAL_TRIALS research · 2025-10-23Clinical Trial Update: Ventripoint Single Ventricle Study [NA]
A Duke University–sponsored clinical trial named Ventripoint Single Ventricle Study is currently recruiting to investigate therapy for singl…
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Cholate Clearance in Fontan and Heart Failure
A HepQuant-sponsored clinical trial is currently recruiting to study cholate clearance in patients with Fontan physiology and right heart fa…
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: The iPeer2Peer Mentorship Program for Young Adults With Heart Disease [NA]
This is a clinical trial record describing the iPeer2Peer mentorship program for young adults with heart disease, currently not yet recruiti…
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CLINICAL_TRIALS research · 2025-07-28Clinical Trial Update: Impact of Early Fortini Initiation on Growth and Interstage Outcomes in Infants With Single Ventricle Physiology [NA]
This clinical trial investigates whether early initiation of Fortini nutrition improves growth and interstage outcomes in infants with singl…
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CLINICAL_TRIALS trial_result · 2025-06-27Clinical Trial Update: Intramyocardial Injection of Autologous UCB-MNC During Fontan Surgery for SRV Dependent CHD [Phase 1]
Phase 1 trial evaluating intramyocardial injection of autologous umbilical cord blood mononuclear cells during Fontan surgery for single-ven…
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CLINICAL_TRIALS research · 2025-03-13Clinical Trial Update: Characterizing the Effect of Dopamine on Markers of Lymph Re-circulation in Fontan-associated Protein-losing Enteropathy
This clinical trial update notes an enrolling-by-invitation study to characterize the effect of dopamine on markers of lymphatic circulation…
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CLINICAL_TRIALS trial_result · 2025-02-10Clinical Trial Update: Simple Non-invasive Breathing Device to Improve Pulmonary Flow Pusatility in Single Ventricle Post Fontan [NA]
This entry reports a completed clinical trial evaluating a simple non-invasive breathing device to improve pulmonary flow pulsatility in pat…
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CLINICAL_TRIALS research · 2024-12-16Clinical Trial Update: Cardiac Magnetic Resonance Stress-perfusion Study in Patinets with Fontan Circulation
Karolinska Institutet reports a clinical trial evaluating cardiac magnetic resonance stress-perfusion in patients with Fontan circulation (s…
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CLINICAL_TRIALS research · 2024-10-16Clinical Trial Update: Fontan Circulation and Reproductive Health in a National Swedish Cohort
A national Swedish cohort study is recruiting to examine how Fontan circulation affects reproductive health in individuals with single-ventr…
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CLINICAL_TRIALS trial_result · 2024-08-30Clinical Trial Update: Inspiratory Training in Children After Fontan [NA]
Clinical trial update notes the completion of a study evaluating inspiratory muscle training in children after the Fontan procedure for resp…
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CLINICAL_TRIALS trial_result · 2022-03-28Clinical Trial Update: Pharmacokinetic, Pharmacodynamic, Safety, and Efficacy Study of Rivaroxaban for Thromboprophylaxis in Pediatric Participants 2 to 8 Years of Age After the Fontan Procedure [Phase 3]
Phase 3 pediatric trial evaluating rivaroxaban for thromboprophylaxis after Fontan procedure in children ages 2 to 8, assessing PK/PD, safet…
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CLINICAL_TRIALS trial_result · 2018-05-07Clinical Trial Update: The Effects of Ambrisentan on Exercise Capacity in Fontan Patients [Phase 4]
A Phase 4 trial assessed whether ambrisentan improves exercise capacity in Fontan patients with single-ventricle physiology; the study has c…
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CLINICAL_TRIALS trial_result · 2018-05-04Clinical Trial Update: The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart Disease [Phase 4]
Phase 4 trial evaluating the effect of eplerenone on markers of myocardial fibrosis in adults with congenital heart disease; the study was t…
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CLINICAL_TRIALS trial_result · 2018-04-18Clinical Trial Update: Colloid Osmotic Pressure in Patients With Fontan Circulation
This clinical trial update reports the completion of a study assessing colloid osmotic pressure in patients with Fontan circulation, a palli…
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CLINICAL_TRIALS trial_result · 2018-03-02Clinical Trial Update: A Pilot Study Investigating the Clinical Use of Tissue Engineered Vascular Grafts in Congenital Heart Surgery [Phase 1]
Phase 1 pilot study evaluating tissue-engineered vascular grafts in congenital heart surgery has completed.
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CLINICAL_TRIALS trial_result · 2017-11-14Clinical Trial Update: Improving Functional Capacity in Fontan Patients Through Inspiratory Muscle Training [NA]
A clinical trial evaluated inspiratory muscle training to improve functional capacity in Fontan patients with single-ventricle congenital he…
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CLINICAL_TRIALS trial_result · 2017-05-10Clinical Trial Update: Upright Versus Supine Exercise Testing in Fontan-palliated Patients
A completed clinical trial evaluating upright versus supine exercise testing in Fontan-palliated patients.
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CLINICAL_TRIALS trial_result · 2017-04-17Clinical Trial Update: Effect of Tadalafil on Exercise Capacity in Pediatric Fontan Patients [Phase 1]
A Phase 1 trial assessing tadalafil on exercise capacity in pediatric Fontan patients with single-ventricle physiology has completed.
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CLINICAL_TRIALS research · 2016-01-20Clinical Trial Update: Cardio Pulmonary Exercise Testing in Patients Post the Fontan Palliation in Comparison With Patients With Repaired Congenital Heart Disease and Healthy Volunteers.
This trial update describes a study that evaluates cardio-pulmonary exercise testing in patients after Fontan palliation. It compares result…
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CLINICAL_TRIALS trial_result · 2015-03-25Clinical Trial Update: Liothyronine in Children With Single Ventricle Congenital Cardiac Malformations Undergoing the Fontan Procedure [Phase 1]
Phase 1 clinical trial update evaluating liothyronine in children with single-ventricle congenital heart defects undergoing the Fontan proce…