Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Sickle Cell Kidney Biorepository
A UT Southwestern Medical Center-sponsored clinical trial registry entry for a Sickle Cell Kidney Biorepository, currently recruiting to col…
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CLINICAL_TRIALS withdrawal · 2026-04-09Clinical Trial Update: Biotin-Acridine Red Cell Exchange Kinetics [Phase 2]
A Phase 2 trial of Biotin-Acridine for sickle cell disease has been withdrawn. The study was sponsored by Cerus Corporation.
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Alternative Dosing And Prevention of Transfusions (ADAPT) [EARLY_Phase 1]
Early Phase 1 clinical trial (ADAPT) at Cincinnati Children's Hospital evaluating alternative dosing and prevention of transfusions in sickl…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Ultrasound Acute Chest Syndrome Sickle Cell Disease [NA]
A clinical trial update shows an ultrasound study evaluating treatment for Acute Chest Syndrome in Sickle Cell Disease is currently recruiti…
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: Study of the Effect of Etavopivat on Cerebral Hemodynamic Response in Children With Sickle Cell Disease [Phase 2]
This clinical trial evaluated the effect of etavopivat on cerebral hemodynamic responses in children with sickle cell disease; the Phase 2 s…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS Study)
A completed NHGRI-sponsored clinical study (INSIGHTS) investigates how the microbiome and environmental factors influence sickle cell diseas…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Blood Collection for Research Related to Certain Diseases Involving Blood Vessels
This update describes ongoing blood collection for research related to diseases involving blood vessels, including sickle cell disease. Enro…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT) [Phase 2]
This is a Phase 2 clinical trial evaluating an immune suppression treatment for people with sickle cell disease or beta-thalassemia undergoi…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Living With Sickle Cell Disease in the COVID-19 Pandemic
This clinical trial update reports on a completed study sponsored by NHGRI evaluating the experiences of people with sickle cell disease dur…
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CLINICAL_TRIALS trial_result · 2026-04-07Clinical Trial Update: Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study [Phase 4]
A Phase 4 rollover study evaluating crizanlizumab in sickle cell disease patients who completed a prior Novartis-sponsored crizanlizumab tri…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Tocilizumab for Acute Chest Syndrome [Phase 2]
This is a Phase 2 clinical trial evaluating Tocilizumab for Acute Chest Syndrome in patients with sickle cell disease; recruitment is ongoin…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS) [Phase 3]
Phase 3 trial update for etavopivat in adults and adolescents with sickle cell disease (HIBISCUS). The study is currently active but not rec…
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CLINICAL_TRIALS withdrawal · 2026-04-03Clinical Trial Update: A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy [Phase 2]
A Phase 2 trial of Mitapivat in participants with sickle cell disease and nephropathy has been withdrawn.
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Sickle Cell, Pain and Mediterranean Diet [NA]
An update about a University of Illinois at Chicago clinical trial investigating sickle cell pain management with a Mediterranean diet, curr…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Pathophysiology of Acute Pain in Patients With Sickle Cell Disease
This clinical trial update reports on a completed NHLBI study investigating the mechanisms underlying acute pain in patients with sickle cel…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Acupressure in Patients With Sickle Cell Disease [NA]
The ClinicalTrials.gov entry notes an acupressure study in patients with Sickle Cell Disease sponsored by Indiana University, currently list…
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Intravenous Gammaglobulin for Sickle Cell Pain Crises [Phase 1, Phase 2]
Phase 1 and Phase 2 clinical trials evaluating intravenous immunoglobulin for pain crises in sickle cell disease have completed.
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD) [Phase 1]
Phase 1b open-label study of DISC-3405 in participants with Sickle cell disease is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Single-dose Pharmacokinetics of Pociredir in Participants With Sickle Cell Disease [Phase 1]
Phase 1 clinical trial evaluating the single-dose pharmacokinetics of Pociredir in participants with sickle cell disease. The study is curre…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: The Feasibility of the Pray Until Something Happens (PUSH) Intervention-OUTPATIENT [NA]
Completed outpatient feasibility study evaluating the Pray Until Something Happens (PUSH) intervention for sickle cell disease.
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Sickle Cell Disease and the Genomic and Gene Therapy Needs of Stakeholders
The clinical trial NCT04416178 sponsored by St. Jude Children’s Research Hospital, focused on genomic and gene therapy needs for sickle cell…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Screening for Renal Complications in Children and Young Adults With Major Sickle Cell Disease [NA]
A clinical trial examining screening for renal complications in children and young adults with major sickle cell disease has completed.
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Evaluation of the Efficacy of Iloprost in the Management of Vaso-occlusive Crises in Adult Patients With Sickle Cell Disease [Phase 3]
Phase 3 clinical trial evaluating iloprost for managing vaso-occlusive crises in adults with sickle cell disease; the study is not yet recru…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE) [Phase 3]
Phase 3 study to evaluate crizanlizumab (5 mg/kg) vs placebo in adolescents and adults with sickle cell disease and frequent vaso-occlusive …
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CLINICAL_TRIALS withdrawal · 2026-03-25Clinical Trial Update: Evaluation of Efficacy and Safety of a Single Dose of Exa-cel in Participants With Severe Sickle Cell Disease, βS/ βC Genotype [Phase 3]
A Phase 3 trial evaluating a single dose of Exa-cel for severe sickle cell disease (βS/βC genotype) has been withdrawn.