Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat [Phase 1, Phase 2]
This clinical trial update reports on the safety, tolerability, pharmacokinetics, and pharmacodynamics of long-term mitapivat dosing in adul…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Pharmacogenetics and Model-Informed Optimisation of Hydroxyurea
Clinical trial exploring pharmacogenetics and model-informed optimization of hydroxyurea for sickle cell disease; status indicates not yet r…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: ATHNdataset Registry
The ATHNdataset Registry is currently recruiting participants; sponsored by the American Thrombosis and Hemostasis Network, the registry cov…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Realizing Effectiveness Across Continents With Hydroxyurea [Phase 2]
Phase 2 clinical trial of hydroxyurea for sickle cell disease in children is active but not recruiting.
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Sickle Cell Children's Exercise Study (SuCCESs) [NA]
This clinical trial update indicates that the Sickle Cell Children's Exercise Study (SuCCESs) sponsored by the University of Maryland is cur…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease [Phase 1]
This is a Phase 1 clinical trial update evaluating haploidentical hematopoietic stem cell transplantation with pre-transplant immunosuppress…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
NIAID-sponsored clinical trial update indicates recruitment is ongoing to collect human biospecimens for basic and clinical research into gl…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia
This clinical trial update notes the completion of a study investigating secondary pulmonary hypertension in adults with sickle cell disease…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Development of a Provider-Focused Intervention to Improve Health Outcomes in Pediatric Sickle Cell Disease [NA]
A clinical trial update describing the development of a provider-focused intervention to improve health outcomes for pediatric sickle cell d…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Solving Stigma Through POV Simulation: Enhancing Pharmacist Empathy-based Practices With Sickle Cell Disease Patients [NA]
This clinical trial update notes enrollment for a study using point-of-view simulation to improve pharmacists' empathy toward patients with …
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD) [Phase 2]
Phase 2 trial evaluating crovalimab as adjunct therapy to prevent vaso-occlusive episodes in sickle cell disease has completed, reporting on…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
A clinical trial evaluating dietary intake and dietary behaviors in adults with sickle cell disease, currently recruiting at the NIH Clinica…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating transplantation of CRISPR-modified hematopoietic progenitor stem cells (CRISPR_SCD001) in patients …
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Developing the Family Map: Looking at Communal Coping
NHGRI-funded clinical trial update on the Developing the Family Map study, examining communal coping, which has completed; conditions involv…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis [Phase 2]
Phase 2 clinical trial evaluating safety, efficacy, and pharmacokinetics of CSL889 in adults and adolescents with sickle cell disease during…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease [Phase 3]
Sanofi is conducting a Phase 3 trial to evaluate a single-dose, 21-valent pneumococcal conjugate vaccine in children and adolescents with si…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Functional Ovarian Reserve in Sickle Cell Disease
A clinical trial update shows that the study on functional ovarian reserve in individuals with sickle cell disease is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: OMEGA-3-FATTY ACIDS IN CHILDREN WITH SICKLE CELL DISEASE [NA]
A clinical trial update shows a study evaluating omega-3 fatty acids in children with sickle cell disease. The study is currently not yet re…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Open-Label Extension Study to Pioneer Study 6058-SCD-101 [Phase 2]
Open-label extension of the Phase 2 Pioneer study 6058-SCD-101 for sickle cell disease. Enrollment is by invitation and ongoing.
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease [Phase 1, Phase 2]
A phase 1/2 clinical trial is evaluating Acceptance and Commitment Therapy for adolescents and young adults with sickle cell disease. The st…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Managed Access Programs for SEG101, Crizanlizumab
Clinical trial update describing managed access programs for crizanlizumab (SEG101) for sickle cell disease.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease [Phase 3]
Phase 3 clinical trial update investigating the efficacy and safety of rilzabrutinib in participants aged 10 to 65 with sickle cell disease;…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Alendronate for Osteonecrosis in Adults With Sickle Cell Disease [Phase 2]
A Phase 2 clinical trial is evaluating alendronate for treating osteonecrosis in adults with sickle cell disease and is currently recruiting…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease [Phase 2]
This is a Phase 2 clinical trial evaluating intravenous L-Citrulline for vaso-occlusive pain episodes in sickle cell disease, currently recr…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Sickle Cell Disease Obstetric Multi-Disciplinary Care Programme
A Vanderbilt-led clinical trial on an obstetric multidisciplinary care program for patients with sickle cell disease is currently active but…