Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2017-04-26Clinical Trial Update: Use of Hydroxyurea and Magnesium Pidolate for Treatment of Sickle Cell Disease [Phase 1]
Phase 1 clinical trial evaluating hydroxyurea in combination with magnesium pidolate for sickle cell disease has completed.
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CLINICAL_TRIALS trial_result · 2017-04-19Clinical Trial Update: Quality of Care of Children With Sickle Cell Disease (SCD) Screened at Birth in France
This completed clinical trial update describes the quality of care for children with sickle cell disease who were screened at birth in Franc…
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CLINICAL_TRIALS trial_result · 2017-04-13Clinical Trial Update: Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia [Phase 2]
Phase 2 clinical trial evaluating sildenafil for treatment of priapism in men with sickle cell disease has completed and results are posted.
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CLINICAL_TRIALS trial_result · 2017-04-12Clinical Trial Update: Drug Interaction Study of GBT440 With Caffeine, S-warfarin, Omeprazole, and Midazolam in Healthy Subjects [Phase 1]
Phase 1 study assessing potential drug interactions between GBT440 (voxelotor) and caffeine, S-warfarin, omeprazole, and midazolam in health…
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CLINICAL_TRIALS trial_result · 2017-04-12Clinical Trial Update: A Study of the Absorption, Metabolism, and Excretion of GBT440 in Healthy Male Subjects [Phase 1]
Phase 1 trial evaluating the absorption, metabolism, and excretion of GBT440 (voxelotor) in healthy male subjects has completed. The update …
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CLINICAL_TRIALS trial_result · 2017-04-12Clinical Trial Update: A Single-Dose Relative Bioavailability Study Of GBT440 300 mg Capsules in Healthy Subjects [Phase 1]
Phase 1 study of voxelotor (GBT440) 300 mg capsules in healthy subjects to assess single-dose relative bioavailability.
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CLINICAL_TRIALS trial_result · 2017-04-11Clinical Trial Update: Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea [Phase 3]
A Phase 3 trial investigating a shift from transfusions to hydroxyurea in sickle cell anemia was terminated, with results posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-03-28Clinical Trial Update: Molecular Phenotyping of Asthma in Sickle Cell Disease
A completed clinical trial investigating molecular phenotyping of asthma in individuals with sickle cell disease.
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CLINICAL_TRIALS trial_result · 2017-03-24Clinical Trial Update: Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease [Phase 2]
Phase 2 trial evaluating different dose regimens of Aes-103 over 28 days in subjects with stable sickle cell disease; study terminated with …
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CLINICAL_TRIALS withdrawal · 2017-03-24Clinical Trial Update: Comparison of Patient Controlled Analgesia (PCA) Versus Bolus Narcotic Therapy for the Treatment of Vaso-Occlusive Crisis (VOC) [Phase 2]
A Phase 2 trial comparing patient-controlled analgesia versus bolus narcotic therapy for vaso-occlusive crisis in sickle cell disease was wi…
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CLINICAL_TRIALS trial_result · 2017-03-01Clinical Trial Update: Decitabine for High-Risk Sickle Cell Disease [Phase 2]
This update reports results from a Phase 2 clinical trial of decitabine for high-risk sickle cell disease, with results posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-02-28Clinical Trial Update: SANGUINATE™ in Sickle Cell Disease Associated Leg Ulcer [Phase 2]
Phase 2 study of SANGUINATE for leg ulcers in sickle cell disease has completed, reporting results from the trial.
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CLINICAL_TRIALS research · 2017-02-23Clinical Trial Update: Hydroxyurea in the Emergency Room to Lessen Pain in Sickle Cell Crisis [Phase 2]
Phase 2 clinical trial evaluating hydroxyurea in the emergency department to reduce pain during sickle cell crisis. The status is currently …
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CLINICAL_TRIALS trial_result · 2017-02-17Clinical Trial Update: Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trial [Phase 1]
Phase 1 feasibility trial evaluating inhaled corticosteroids to prevent recurrence of acute chest syndrome in children aged 1-4 with sickle …
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CLINICAL_TRIALS trial_result · 2017-02-15Clinical Trial Update: Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease - Pilot Intervention Study [Phase 1]
Clinical trial update on a Phase 1 pilot intervention study examining cognitive function and brain abnormalities in adults with sickle cell …
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CLINICAL_TRIALS trial_result · 2017-02-15Clinical Trial Update: Decompression Coring Versus Conservative Therapy in Patients With Avascular Necrosis of the Hip Related to Sickle Cell Disease [NA]
This update reports completion of a trial comparing decompression coring surgery to conservative treatment for avascular necrosis of the hip…
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CLINICAL_TRIALS trial_result · 2017-02-08Clinical Trial Update: Clinical Importance of Treating Iron Overload in Sickle Cell Disease [Phase 3]
This is a Phase 3 trial update about the clinical importance of treating iron overload in sickle cell disease. The study status is TERMINATE…
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CLINICAL_TRIALS trial_result · 2017-02-08Clinical Trial Update: Safety and Efficacy of Sodium Nitrite in Sickle Cell Disease [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating sodium nitrite for safety and efficacy in sickle cell disease was terminated; results were posted in 2…
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CLINICAL_TRIALS trial_result · 2017-02-01Clinical Trial Update: Web-MAP Intervention for Youth With Sickle Cell Disease [NA]
Completed clinical trial evaluating a Web-MAP intervention for youths with Sickle Cell Disease.
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CLINICAL_TRIALS trial_result · 2017-01-25Clinical Trial Update: Cognitive Behavioral Therapy and Real-time Self-management Intervention for SCD Via Mobile Applications [NA]
A completed clinical trial evaluating a mobile-based cognitive behavioral therapy and real-time self-management intervention for sickle cell…
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CLINICAL_TRIALS withdrawal · 2017-01-19Clinical Trial Update: Androgen Regulation of Priapism in Sickle Cell Disease [EARLY_Phase 1]
This document announces the withdrawal of an early-phase trial investigating androgen regulation of priapism in sickle cell disease.
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CLINICAL_TRIALS research · 2017-01-04Clinical Trial Update: A Pilot Study of Fecal Microbiome and Neutrophil Cellular Adhesion Molecules in Patients With Sickle Cell Disease (SCD)
This pilot clinical trial investigates the relationship between the fecal microbiome and neutrophil cellular adhesion molecule markers in pa…
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CLINICAL_TRIALS withdrawal · 2016-12-23Clinical Trial Update: Exhaled Carbon Monoxide as a Marker of Hemolysis in Sickle Cell Disease- an Exploratory Study
An exploratory trial evaluating exhaled carbon monoxide as a marker of hemolysis in sickle cell disease has been withdrawn. The sponsor is U…
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CLINICAL_TRIALS trial_result · 2016-12-19Clinical Trial Update: Effect of Simvastatin Treatment on Vaso-occlusive Pain in Sickle Cell Disease [Phase 1, Phase 2]
This document reports a completed Phase 1/2 clinical trial evaluating simvastatin for reducing vaso-occlusive pain in sickle cell disease. R…
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CLINICAL_TRIALS trial_result · 2016-12-05Clinical Trial Update: Allogeneic Genoidentical Stem Cell Transplantation in Children With Sickle-cell Anemia and Cerebral Vasculopathy [NA]
This clinical trial update indicates completion of a study evaluating allogeneic genoidentical stem cell transplantation in children with si…