Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2017-12-11Clinical Trial Update: Implication of the Oxydative Stress in the Pathophysiology of Sickle Cell Anemia: [NA]
A completed clinical trial update examining the role of oxidative stress in the pathophysiology of sickle cell disease.
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CLINICAL_TRIALS research · 2017-11-24Clinical Trial Update: Substudy of CADRE: for People With Extreme Phenotype: BIOCADRE
A clinical trial substudy (BIOCADRE) under the CADRE program is planned for people with extreme phenotype in sickle cell disease; sponsor is…
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CLINICAL_TRIALS research · 2017-11-20Clinical Trial Update: Autologous Bone Marrow Stem Cell Transplantation for Osteonecrosis in Sickle Cell Disease [Phase 1, Phase 2]
This entry provides an update on a Phase 1/Phase 2 clinical trial evaluating autologous bone marrow stem cell transplantation for osteonecro…
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CLINICAL_TRIALS trial_result · 2017-10-27Clinical Trial Update: Microvessels and Heart Problems in Sickle Cell Disease
NHLBI-sponsored clinical trial investigating microvessel and heart problems in sickle cell disease has completed.
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CLINICAL_TRIALS withdrawal · 2017-10-18Clinical Trial Update: Risk-based Therapy for Sickle Cell Anemia: A Feasibility Study [Phase 2]
This Phase 2 feasibility trial of risk-based therapy for sickle cell disease has been withdrawn.
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CLINICAL_TRIALS trial_result · 2017-10-17Clinical Trial Update: Point-of-Delivery Prenatal Test Results Through mHealth to Improve Birth Outcome [NA]
An update on trial results evaluating a point-of-delivery prenatal test delivered via mobile health to improve birth outcomes.
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CLINICAL_TRIALS trial_result · 2017-09-29Clinical Trial Update: Bone Marrow Transplantation in Young Adults With Severe Sickle Cell Disease [Phase 2]
Phase 2 clinical trial evaluating bone marrow transplantation in young adults with severe sickle cell disease. The study is completed and re…
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CLINICAL_TRIALS trial_result · 2017-08-22Clinical Trial Update: Safety of ICL670 vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions [Phase 2]
A completed Phase 2 safety study comparing ICL670 with deferoxamine in sickle cell disease patients with transfusional iron overload.
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CLINICAL_TRIALS trial_result · 2017-08-10Clinical Trial Update: A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemia [Phase 3]
Phase III trial evaluating safety and efficacy of L-Glutamine for sickle cell disease and sickle β0-thalassemia has completed with results p…
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CLINICAL_TRIALS trial_result · 2017-08-07Clinical Trial Update: Clinical Trial to Study the Safety and Tolerability of Memantin Mepha® in Sickle Cell Disease Patients [Phase 2]
A Phase 2 trial evaluating the safety and tolerability of Memantin Mepha in adults with sickle cell disease has completed.
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CLINICAL_TRIALS trial_result · 2017-08-04Clinical Trial Update: Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease [Phase 4]
Phase 4 clinical trial update comparing acute pain management protocols for patients with sickle cell disease; results were posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-08-02Clinical Trial Update: A Study to Compare if the Uptake of Ticagrelor in the Body Differs When Different Tablets Are Administered [Phase 1]
A Phase 1 pharmacokinetic study from AstraZeneca compared Ticagrelor absorption using different tablet formulations in individuals with sick…
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CLINICAL_TRIALS trial_result · 2017-08-01Clinical Trial Update: Evaluating Thromboelastography (TEG) and ETP in Sickle Adults
This clinical trial update notes the completion of a study evaluating thromboelastography (TEG) and endogenous thrombin potential (ETP) in a…
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CLINICAL_TRIALS trial_result · 2017-07-25Clinical Trial Update: Sickle Cell Disease Conditioning for Bone Marrow Transplant [Phase 1]
Phase 1 trial evaluating conditioning regimens for bone marrow transplantation in sickle cell disease has completed.
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CLINICAL_TRIALS trial_result · 2017-07-17Clinical Trial Update: Losartan for Sickle Cell Kidney Disease [EARLY_Phase 1]
This update reports the completion of an early-phase (Phase 1) trial evaluating losartan for sickle cell kidney disease.
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FDA approval · 2017-07-07FDA Approved: ENDARI — Original Application (Emmaus Medical, Inc.)
FDA approved ENDARI (L-glutamine) from Emmaus Medical, Inc. for reducing acute complications in patients with sickle cell disease.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Nitric Oxide and Sickle Cell Pain
A National Institute of Nursing Research study evaluating inhaled nitric oxide for sickle cell pain has been terminated.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Heart Disease in Sickle Cell Anemia
The clinical trial examining heart disease in patients with sickle cell disease, including pulmonary hypertension, has completed.
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CLINICAL_TRIALS trial_result · 2017-06-08Clinical Trial Update: Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease [Phase 1]
A Phase 1 trial evaluating propranolol and red blood cell adhesion in non-asthmatic children with sickle cell disease was terminated.
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CLINICAL_TRIALS trial_result · 2017-05-25Clinical Trial Update: Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 or 24 Weeks in Genotype 1 or 4 HCV Infected Adults With Sickle Cell Disease [Phase 2]
Phase 2 trial evaluating fixed-dose Ledipasvir/Sofosbuvir for 12 or 24 weeks in adults with Hepatitis C infection and sickle cell disease; r…
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CLINICAL_TRIALS trial_result · 2017-05-25Clinical Trial Update: Use of Mobile Technology for Intensive Training in Medication Management [NA]
This clinical trial update notes a completed Duke University study evaluating the use of mobile technology to provide intensive training in …
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CLINICAL_TRIALS trial_result · 2017-05-11Clinical Trial Update: Evaluation of Non-invasive Endothelial Function in Children Sickle by Vascular Ultrasound [NA]
A completed clinical trial evaluating non-invasive measures of endothelial function in children with sickle cell disease using vascular ultr…
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CLINICAL_TRIALS trial_result · 2017-05-09Clinical Trial Update: Stem Cell Transplant for Hemoglobinopathy [Phase 2, Phase 3]
Phase 2/3 trial update on stem cell transplant for hemoglobinopathy shows completed status with results posted.
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CLINICAL_TRIALS trial_result · 2017-05-03Clinical Trial Update: A Brief Laboratory-Based Hypnosis Session for Pain in Sickle Cell Disease [NA]
A completed UCLA-sponsored clinical trial evaluating a brief laboratory-based hypnosis session for pain in sickle cell disease.
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CLINICAL_TRIALS trial_result · 2017-04-26Clinical Trial Update: Haploidentical Stem Cell Transplant for Patients With Sickle Cell Disease and Prior Stroke or Abnormal Transcranial Ultrasound [Phase 1]
A Phase 1 trial evaluating haploidentical stem cell transplantation in patients with sickle cell disease who have had prior stroke or abnorm…