Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2020-01-22Clinical Trial Update: Methadone in Pediatric and Adult Sickle Cell Patients [NA]
A completed clinical trial evaluating methadone in pediatric and adult patients with sickle cell disease; results posted in 2020.
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FDA approval · 2019-12-30FDA Approved: DEFERASIROX — Original Application (Xiromed, LLC)
FDA approved Xiromed, LLC's generic deferasirox (DEFERASIROX) through an original ANDA.
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CLINICAL_TRIALS trial_result · 2019-12-16Clinical Trial Update: Hydroxyurea for the Treatment of Patients With Sickle Cell Anemia [Phase 2]
Phase 2 clinical trial update for hydroxyurea in sickle cell anemia.
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FDA approval · 2019-11-25FDA Approved: OXBRYTA — Original Application (Global Blood Therapeutics, Inc, A subsidiary of Pfizer Inc.)
FDA approved OXBRYTA (voxelotor) under the original application for the treatment of sickle cell disease.
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FDA approval · 2019-11-15FDA Approved: ADAKVEO — Original Application (Novartis Pharmaceuticals Corporation)
FDA approved ADAKVEO (crizanlizumab) from Novartis as an original biologics license application to reduce the frequency of vaso-occlusive cr…
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FDA approval · 2019-11-01FDA Approved: ENDARI — Supplemental Application (Emmaus Medical, Inc.)
FDA approved a supplemental application for ENDARI (glutamine) by Emmaus Medical, Inc., resulting in an updated regulatory status for the pr…
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CLINICAL_TRIALS trial_result · 2019-11-01Clinical Trial Update: A Phase - IIa - IIb, Trial to Study the Safety, Tolerability and Efficacy of Memantine as a Long-term Treatment of SCD [Phase 2]
Phase 2 trial examining memantine as a long-term treatment for sickle cell disease to assess safety, tolerability, and efficacy.
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CLINICAL_TRIALS trial_result · 2019-10-14Clinical Trial Update: Haploidentical PBMC Transplant for Severe Congenital Anemias [Phase 1, Phase 2]
This clinical trial update concerns haploidentical peripheral blood mononuclear cell transplant for sickle cell anemia, conducted in Phase 1…
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CLINICAL_TRIALS trial_result · 2019-09-23Clinical Trial Update: Comparison of Allogeneic Matched Related Haematopoietic Stem Cell Transplantation After a Reduced Intensity Conditioning Regimen With Standard of Care in Adolescents and Adults With Severe Sickle Cell Disease [Phase 3]
A Phase 3 clinical trial comparing allogeneic matched related hematopoietic stem cell transplantation after reduced-intensity conditioning v…
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CLINICAL_TRIALS trial_result · 2019-09-13Clinical Trial Update: Music Therapy in Sickle Cell Transition Study [NA]
A completed clinical trial studying music therapy in sickle cell disease has results posted.
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CLINICAL_TRIALS trial_result · 2019-08-28Clinical Trial Update: SCD-Haplo: Phase II Study of HLA-Haploidentical SCT for Aggressive SCD [Phase 2]
Phase II study of HLA-haploidentical stem cell transplantation for aggressive sickle cell disease was terminated; results posted in 2019.
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CLINICAL_TRIALS trial_result · 2019-08-06Clinical Trial Update: Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell Disease [Phase 1, Phase 2]
A Phase 1/2 clinical trial assessed algorithm-based hydroxyurea dosing for sickle cell disease, focusing on fetal hemoglobin response, acute…
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CLINICAL_TRIALS trial_result · 2019-08-02Clinical Trial Update: TAPS2 Transfusion Antenatally in Pregnant Women With SCD [Phase 2]
Phase 2 clinical trial update evaluating antenatal transfusion in pregnant women with sickle cell disease (SCD).
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CLINICAL_TRIALS trial_result · 2019-07-16Clinical Trial Update: Sevuparin Infusion for the Management of Acute VOC in Subjects With SCD [Phase 2]
Phase 2 clinical trial update for sevuparin infusion in managing acute vaso-occlusive crises in sickle cell disease has been completed.
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CLINICAL_TRIALS trial_result · 2019-07-16Clinical Trial Update: Feasibility Study of Unfractionated Heparin in Acute Chest Syndrome [Phase 2]
A Phase 2 feasibility trial of unfractionated heparin for acute chest syndrome in sickle cell disease was terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2019-07-15Clinical Trial Update: Music Therapy in Sickle Cell Pain Mixed Methods Study [NA]
A completed mixed-methods study evaluating music therapy for pain management in sickle cell disease; results posted in 2019.
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CLINICAL_TRIALS trial_result · 2019-06-26Clinical Trial Update: Allogeneic SCT of CordIn™, in Patients With Hemoglobinopathies [Phase 1, Phase 2]
Phase 1/2 clinical trial update for Allogeneic cord blood stem cell therapy CordIn in sickle cell disease and thalassemia; study status term…
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CLINICAL_TRIALS trial_result · 2019-06-17Clinical Trial Update: Comparison of Patient Centered Outcomes for People With Sickle Cell Disease in the Acute Care Setting
A completed clinical trial evaluating patient-centered outcomes for individuals with sickle cell disease in acute care settings; results pos…
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FDA approval · 2019-05-24FDA Approved: EXJADE — Supplemental Application (Novartis Pharmaceuticals Corporation)
The FDA approved a supplemental application for Exjade (deferasirox) submitted by Novartis Pharmaceuticals Corporation.
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CLINICAL_TRIALS trial_result · 2019-05-15Clinical Trial Update: A Rehabilitation Program in Children With Sickle Cell Disease and Cognitive Deficits: a Pilot Study [NA]
Pilot clinical trial assessing a rehabilitation program for children with sickle cell disease and cognitive deficits; study completed with r…
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CLINICAL_TRIALS trial_result · 2019-04-17Clinical Trial Update: A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome [Phase 1]
Phase 1 study evaluating continuous intravenous L-citrulline during sickle cell pain crisis or acute chest syndrome; completed with results …
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CLINICAL_TRIALS trial_result · 2019-04-17Clinical Trial Update: Non-Myeloablative Bone Marrow Transplant for Patients With Sickle Cell Anemia and Other Blood Disorders [Phase 2]
Phase 2 clinical trial update on non-myeloablative bone marrow transplant for sickle cell disease and other blood disorders; study terminate…
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CLINICAL_TRIALS trial_result · 2019-04-03Clinical Trial Update: A Reduced Toxicity Allogeneic Unrelated Donor Stem Cell Transplantation (SCT) for Severe Sickle Cell Disease [Phase 2]
Phase 2 trial update on reduced-toxicity, allogeneic unrelated donor stem cell transplantation for severe sickle cell disease; study termina…
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CLINICAL_TRIALS trial_result · 2019-04-02Clinical Trial Update: Pain Management in Children and Young Adults With Sickle Cell Disease [Phase 2]
Phase 2 clinical trial update on pain management in children and young adults with sickle cell disease; results posted after completion.
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CLINICAL_TRIALS trial_result · 2019-03-26Clinical Trial Update: Phase 2 Study of Montelukast for the Treatment of Sickle Cell Anemia [Phase 2]
A Phase 2 clinical trial evaluating montelukast for sickle cell anemia has completed; results were posted in 2019.