Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2024-10-29Clinical Trial Update: Decision-Making and Quality of Life Surrounding Hematologic Disease and Gene Therapy
A clinical trial update discusses decision-making and quality-of-life considerations for hematologic diseases undergoing gene therapy, with …
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CLINICAL_TRIALS trial_result · 2024-10-28Clinical Trial Update: Pharmacokinetics of Oral Hydroxyurea Solution [Phase 1, Phase 2]
Completed Phase 1/2 pharmacokinetics study of an oral hydroxyurea solution in sickle cell disease and related hemoglobin disorders, with res…
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CLINICAL_TRIALS trial_result · 2024-10-28Clinical Trial Update: HRV-B for Symptom Management in Sickle Cell Patients [NA]
Clinical trial update indicates completion of a study evaluating HRV-B for symptom management in sickle cell disease. The snippet does not r…
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CLINICAL_TRIALS withdrawal · 2024-10-24Clinical Trial Update: Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathies [EARLY_Phase 1]
The Early Phase 1 trial investigating pre-transplant immunosuppression and donor stem cell transplantation for severe hemoglobinopathies has…
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EMA withdrawal · 2024-10-08EMA Suspended: Oxbryta (voxelotor) — Pfizer Europe MA EEIG
The EMA has suspended the EU marketing authorization for Oxbryta (voxelotor) by Pfizer Europe MA EEIG, affecting its use for sickle cell dis…
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CLINICAL_TRIALS trial_result · 2024-10-08Clinical Trial Update: A Study Evaluating the Safety and Efficacy of Lovo-cel in Severe Sickle Cell Disease [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the safety and efficacy of Lovo-cel in severe sickle cell disease has completed, with results posted o…
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CLINICAL_TRIALS research · 2024-10-04Clinical Trial Update: The Relationship of Platelet Counts With Sickle Cell Anemia in the Eastern Region of Saudi Arabia
This clinical trial update describes a study assessing the relationship between platelet counts and sickle cell disease in the Eastern Regio…
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CLINICAL_TRIALS trial_result · 2024-10-01Clinical Trial Update: HEMAGO Monitoring and Impact on the Occurrence of Complications During Pregnancy in Sickle Cell Patients
A completed clinical trial evaluating the HEMAGO monitoring system and its effect on pregnancy-related complications in women with Sickle Ce…
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EMA safety_alert · 2024-09-26EMA recommends suspension of sickle cell disease medicine Oxbryta
EMA recommends suspending the sickle cell disease medicine Oxbryta (voxelotor) as a precaution while emerging data are reviewed.
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CLINICAL_TRIALS research · 2024-09-26Clinical Trial Update: Screening of Coexistence Between Sickle Cell Anaemia and G6PD Deficiency
Clinical trial update indicates a screening study to assess coexistence between sickle cell disease and glucose-6-phosphate dehydrogenase de…
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CLINICAL_TRIALS trial_result · 2024-09-24Clinical Trial Update: Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503) [Phase 2]
This Phase 2 trial (BMT CTN 1503) compares bone marrow transplantation versus standard of care in patients with severe sickle cell disease, …
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FDA approval · 2024-09-23FDA Approved: HYDROXYUREA — Supplemental Application (Teva Pharmaceuticals USA, Inc.)
FDA approved Teva Pharmaceuticals USA, Inc.'s supplemental application for Hydroxyurea, confirming an updated approval for the generic produ…
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CLINICAL_TRIALS trial_result · 2024-09-20Clinical Trial Update: A Trial for Prevention of Recurrent Ischemic Priapism in Men With Sickle Cell Disease: A Pilot Study [Phase 2]
A Phase 2 pilot trial, sponsored by Vanderbilt University Medical Center, evaluated prevention of recurrent ischemic priapism in men with si…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Pharmacokinetics and Pharmacodynamics of Rifaximin Novel Formulations in Patients With Sickle Cell Disease [Phase 2]
Phase 2 trial assessing the pharmacokinetics and pharmacodynamics of rifaximin novel formulations in sickle cell disease has completed, with…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: L-citrulline Injection in Patients Aged 6-21 Years Old with Sickle Cell Disease Presenting with Vaso-Occlusive Crisis (VOC) [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating intravenous L-citrulline in youths with sickle cell disease presenting with vaso-occlusive crisis was …
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CLINICAL_TRIALS trial_result · 2024-09-03Clinical Trial Update: LCI-HEM-SCD-ST3P-UP-001: The Sickle Cell Trevor Thompson Transition Project (ST3P-UP Study) [NA]
The Sickle Cell Trevor Thompson Transition Project (ST3P-UP) has completed and posted results. The trial was sponsored by Wake Forest Univer…
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CLINICAL_TRIALS research · 2024-08-30Clinical Trial Update: Ketorolac for Acute Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease [Phase 4]
Phase 4 clinical trial evaluating ketorolac for acute vaso-occlusive crisis in pediatric sickle cell disease; status is not yet recruiting.
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CLINICAL_TRIALS research · 2024-08-27Clinical Trial Update: ESCORT-HU Extension: European Sickle Cell Disease Cohort - Hydroxyurea - Extension Study
Extension study update for the European sickle cell disease cohort evaluating hydroxyurea (ESCORT-HU Extension); current status is active bu…
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CLINICAL_TRIALS research · 2024-08-23Clinical Trial Update: Testing the Sickle Cell Caregiver Collaboration for Child Development (SCCCD) Intervention [NA]
Clinical trial update for the Sickle Cell Caregiver Collaboration for Child Development (SCCCD) intervention assessing caregiver collaborati…
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CLINICAL_TRIALS research · 2024-08-22Clinical Trial Update: Development and Evaluation of an Information Management System and Communication System for Population-wide Point-of-care Infant Sickle Cell Disease Screening [NA]
A clinical trial update describing the development and evaluation of an information management and communication system for population-wide …
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CLINICAL_TRIALS trial_result · 2024-08-16Clinical Trial Update: SMYLS: A Self-management Program for Youth Living With Sickle Cell Disease [NA]
SMYLS is a self-management program for youths living with sickle cell disease. The trial has completed and posted its results on 2024-08-16.
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CLINICAL_TRIALS trial_result · 2024-08-09Clinical Trial Update: Vitamin D for Sickle-cell Respiratory Complications [Phase 2]
Phase 2 trial evaluating Vitamin D supplementation for respiratory complications in sickle cell disease has completed and results were poste…
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CLINICAL_TRIALS withdrawal · 2024-08-09Clinical Trial Update: Voxelotor Brain Oxygenation and Neurocognitive Study [Phase 4]
Pfizer-sponsored Phase 4 study evaluating voxelotor for brain oxygenation and neurocognitive outcomes in sickle cell disease has been withdr…
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CLINICAL_TRIALS trial_result · 2024-08-07Clinical Trial Update: Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease [Phase 1, Phase 2]
Describes a Phase 1/2 nonmyeloablative haploidentical peripheral blood stem cell transplantation approach for sickle cell disease. The trial…
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CLINICAL_TRIALS research · 2024-07-31Clinical Trial Update: Clinical Study of BRL-101 in Severe SCD [NA]
Clinical trial update indicating that BRL-101 is enrolling by invitation for severe sickle cell disease.