Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-06-02Clinical Trial Update: CS-206 in Patients With Sickle Cell Disease [EARLY_Phase 1]
CS-206 is planned for an early Phase 1 trial in patients with Sickle Cell Disease and is currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis [Phase 3]
This update describes a Phase 3 clinical trial evaluating intravenous L-Citrulline in patients aged 6-21 with sickle cell disease presenting…
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Ketamine for Acute Painful Crisis in Sickle Cell Disease Patients [NA]
Clinical trial update reports that a study evaluating ketamine for acute painful crisis in sickle cell disease has completed enrollment and …
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: Shared-Decision Making for Hydroxyurea [NA]
Clinical trial update indicating that results from a hydroxyurea study in children with sickle cell anemia have been posted after completion…
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CLINICAL_TRIALS research · 2025-05-25Clinical Trial Update: A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease [Phase 1]
This clinical trial update describes a Phase 1 study of nicotinamide with oral tetrahydrouridine and decitabine for high-risk sickle cell di…
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CLINICAL_TRIALS other · 2025-05-25Clinical Trial Update: Megakaryocyte Heterogeneity in Sickle Cell Disease
This clinical trial update reports an ongoing study examining megakaryocyte heterogeneity in sickle cell disease, with recruitment not yet s…
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: A Study to Assess the Safety and Pharmacokinetics of HBI-002, an Oral Carbon Monoxide Therapeutic, in Healthy Volunteers [Phase 1]
Phase 1 study evaluating the safety and pharmacokinetics of HBI-002, an oral carbon monoxide–releasing therapeutic, in healthy volunteers; t…
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: Role of Inflammasome in Platelet Activation in Sickle Cell Disease Patient
A completed clinical trial examining the role of inflammasome activation in platelet activation among patients with sickle cell disease.
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease [Phase 2]
A Phase 2 clinical trial evaluating myeloablative conditioning, prophylactic defibrotide, and haploidentical allogeneic stem cell transplant…
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CLINICAL_TRIALS trial_result · 2025-05-14Clinical Trial Update: SIKAMIC (SIklos on Kidney Function and AlbuMInuria Clinical Trial) [Phase 2]
The Phase 2 trial of SIKAMIC for sickle cell disease, evaluating kidney function and albuminuria, has completed. Results were posted on 2025…
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CLINICAL_TRIALS trial_result · 2025-05-07Clinical Trial Update: Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers [Phase 2]
A Phase 2 trial evaluating topical sodium nitrite for sickle cell disease and leg ulcers was terminated, with results posted.
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: PET Imaging of Vaso-Occlusive Crisis (VOC) in SCD [Phase 1]
A Phase 1 clinical trial is evaluating PET imaging to study vaso-occlusive crisis in sickle cell disease. The study is currently recruiting.
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: RH Genotype Matched RBC Transfusions [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/Phase 2 study evaluating RH genotype-matched red blood cell transfusions in patients with sic…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: RHD Genotype Matched Red Cells for Anti-D [EARLY_Phase 1]
Early Phase 1 trial evaluating RHD genotype-matched red blood cells to mitigate Anti-D antibody reactions in sickle cell disease; the study …
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507) [Phase 2]
Phase 2 trial update on haploidentical bone marrow transplantation for sickle cell disease. The study BMTCTN1507 sponsored by the Medical Co…
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CLINICAL_TRIALS trial_result · 2025-04-20Clinical Trial Update: Home-Based Intervention for Chronic Pain in Adults With Sickle Cell Disease [NA]
Completed clinical trial evaluating a home-based intervention to manage chronic pain in adults with sickle cell disease, with results posted…
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CLINICAL_TRIALS research · 2025-04-18Clinical Trial Update: A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001) [Phase 2]
This clinical trial update reports on a Phase 2 gene transfer study aimed at inducing fetal hemoglobin for sickle cell disease (GRASP, BMT C…
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CLINICAL_TRIALS trial_result · 2025-04-17Clinical Trial Update: Hydroxyurea Therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda ( BRAINSAFE-II ) [Phase 3]
Completed Phase 3 trial (BRAINSAFE-II) evaluating hydroxyurea for neurological and cognitive protection in children with sickle cell disease…
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CLINICAL_TRIALS trial_result · 2025-04-17Clinical Trial Update: Interest of Nutritional Care of Children With Sickle Cell Disease on Bone Mineral Density and Body Composition [NA]
A completed clinical trial assessing whether nutritional care improves bone mineral density and body composition in children with sickle cel…
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD) [Phase 1, Phase 2]
This document updates a Phase 1/2 clinical trial of allogeneic stem cell transplantation for aggressive sickle cell disease; the trial is cu…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: Promoting Utilization and Safety of Hydroxyurea Using Precision in Africa [Phase 3]
A Phase 3 clinical trial update describing the use of hydroxyurea with precision medicine approaches to improve utilization and safety for s…
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CLINICAL_TRIALS research · 2025-04-08Clinical Trial Update: Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness [NA]
This clinical trial update describes a study evaluating directly observed therapy for hydroxyurea to improve its effectiveness in sickle cel…
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CLINICAL_TRIALS trial_result · 2025-04-03Clinical Trial Update: A Voxelotor for Sickle Cell Anemia Patients at Highest Risk for Progression of Chronic Kidney Disease [Phase 1, Phase 2]
This clinical trial update reports termination of a Phase 1/2 study evaluating voxelotor (Oxbryta) in sickle cell disease patients at highes…
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CLINICAL_TRIALS research · 2025-04-02Clinical Trial Update: A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301
A long-term follow-up study is ongoing to monitor participants with sickle cell disease or transfusion-dependent beta-thalassemia who receiv…
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CLINICAL_TRIALS research · 2025-04-02Clinical Trial Update: Pilot Study "AHSP as a Biomarker of Sickle Cell Disease in a Population of Adults and Children" [NA]
Pilot study evaluating AHSP as a biomarker for sickle cell disease in adults and children is currently recruiting. The trial is sponsored by…