Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-07-20Clinical Trial Update: Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients [Phase 2]
Phase 2 study evaluating dose confirmation and safety of crizanlizumab in pediatric sickle cell disease patients; results have been posted.
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CLINICAL_TRIALS research · 2025-07-17Clinical Trial Update: Therapeutic Response Evaluation and Adherence Trial (TREAT) [NA]
Therapeutic Response Evaluation and Adherence Trial (TREAT) is currently active but not recruiting. The associated condition is sickle cell …
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CLINICAL_TRIALS trial_result · 2025-07-17Clinical Trial Update: Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE) [Phase 2]
SPHERE is a Phase 2 trial evaluating hydroxyurea to prevent stroke in children with sickle cell disease. Enrollment is by invitation and the…
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CLINICAL_TRIALS research · 2025-07-17Clinical Trial Update: Hydroxyurea Exposure Limiting Pregnancy and Follow-Up Lactation
This clinical trial is evaluating hydroxyurea exposure during pregnancy and lactation in people with sickle cell disease, currently recruiti…
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CLINICAL_TRIALS trial_result · 2025-07-15Clinical Trial Update: The Radiofrequency Therapy in Management of Sickle Cell Disease Chronic Pain RCT Tested the Effect of TECAR Therapy on Sickle Cell Disease Chronic Pain. [NA]
A completed clinical trial evaluated TECAR therapy (radiofrequency energy transfer) for chronic pain in patients with Sickle Cell Disease.
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial enrolling to assess arginine therapy for pain in children with sickle cell disease.
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CLINICAL_TRIALS trial_result · 2025-07-09Clinical Trial Update: Resolution of Sickle Cell Leg Ulcers With Voxelotor [Phase 3]
A Phase 3 trial of voxelotor for resolution of sickle cell leg ulcers has been terminated, and results have been posted.
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: Exploratory Study on Global Reflexology in Sickle Cell Disease [NA]
An exploratory clinical trial examining global reflexology as a treatment for Sickle Cell Disease, with status RECRUITING.
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CLINICAL_TRIALS trial_result · 2025-06-25Clinical Trial Update: Use of Macrolides in Acute Chest Syndrome: A Multicenter Retrospective Study
A multicenter retrospective study evaluates the use of macrolide antibiotics in acute chest syndrome among patients with sickle cell disease…
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CLINICAL_TRIALS research · 2025-06-25Clinical Trial Update: Cannabidiol in Sickle Cell Disease [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating cannabidiol for sickle cell disease is currently recruiting.
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease
The RECIPE trial for sickle cell disease, sponsored by RTI International, is actively recruiting to evaluate recruitment and engagement in c…
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
This clinical trial is evaluating whether matched related donor hematopoietic stem cell transplantation provides better outcomes than diseas…
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia [NA]
This entry reports a study evaluating the effect of MitoQ on platelet function and reactive oxygen species generation in patients with sickl…
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FDA approval · 2025-06-18FDA Approved: ENDARI — Supplemental Application (Emmaus Medical, Inc.)
FDA approved a supplemental application for ENDARI (glutamine) from Emmaus Medical, Inc., under a supplemental approval to update/expand the…
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: Hydroxyurea Optimization Through Precision Study [Phase 3]
A Phase 3 trial evaluating precision optimization of hydroxyurea for sickle cell disease has completed.
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: Effect of Virtual Reality on Pain and Function in Children With Sickle Cell Disease: A Randomized Controlled Trial [NA]
This randomized controlled trial assessed the effect of virtual reality on pain and function in children with sickle cell disease. The study…
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CLINICAL_TRIALS trial_result · 2025-06-13Clinical Trial Update: Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease [Phase 3]
Phase 3 pediatric study evaluating GBT440 (voxelotor) on transcranial Doppler in sickle cell disease was terminated; results have been poste…
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CLINICAL_TRIALS research · 2025-06-13Clinical Trial Update: Uganda Sickle Surveillance Study (US-3)
Uganda Sickle Surveillance Study (US-3) is a Uganda-based clinical trial recruiting participants to study sickle cell disease surveillance, …
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CLINICAL_TRIALS research · 2025-06-11Clinical Trial Update: 131I-apamistamab-based Conditioning for Hematopoietic Stem Cell Transplant (HSCT) in Advanced Sickle Cell Disease (SCD) [Phase 1]
A Phase 1 trial is evaluating 131I-apamistamab-based conditioning for hematopoietic stem cell transplantation in patients with advanced sick…
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CLINICAL_TRIALS research · 2025-06-08Clinical Trial Update: Neonatal Screening for Haemoglobinopathies EmoCamp
This ClinicalTrials.gov entry reports a neonatal screening study for haemoglobinopathies (sickle cell disease) called EmoCamp, which is not …
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CLINICAL_TRIALS research · 2025-06-08Clinical Trial Update: Red Blood Cell Survival in Sickle Cell Disease [Phase 1]
Phase 1 clinical trial investigating red blood cell survival in sickle cell disease has completed.
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell Patients
A clinical trial update indicates the study is currently recruiting to assess whether regional anesthesia can influence inflammatory pathway…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: The Impact of Oxidative Stress on Erythrocyte Biology [Phase 2]
A Phase 2 trial examining the impact of oxidative stress on erythrocyte biology in sickle cell disease was terminated, with results posted.
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell Patients
A clinical trial investigating the molecular and cellular basis of severe dengue in patients with sickle cell disease, currently recruiting.
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell Disease [NA]
A clinical trial is recruiting to evaluate whether Eye Movement Desensitization and Reprocessing (EMDR) therapy reduces pain interference in…