Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-10-01Clinical Trial Update: Outcomes of Vaso-occlusive Crisis in Pediatric Sickle Cell Disease
The update describes outcomes of vaso-occlusive crisis in pediatric sickle cell disease from the clinical trial NCT07200869, which is curren…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell Antibody [Phase 2]
This Phase 2 clinical trial update describes a nonmyeloablative hematopoietic stem cell transplant approach for sickle cell disease patients…
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CLINICAL_TRIALS trial_result · 2025-09-25Clinical Trial Update: A Research Study of the Effect of Etavopivat on Other Drugs in Healthy Participants [Phase 1]
Completed Phase 1 study evaluating the effect of etavopivat on other drugs in healthy participants, sponsored by Novo Nordisk A/S.
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CLINICAL_TRIALS trial_result · 2025-09-24Clinical Trial Update: Daily Vitamin D for Sickle-cell Respiratory Complications [Phase 2]
Phase 2 trial evaluating daily vitamin D for sickle cell–related respiratory complications has completed and posted results.
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: YOLT-204 in Patients With Hemoglobinopathies [EARLY_Phase 1]
This is an early Phase 1 clinical trial update for YOLT-204 in patients with hemoglobinopathies, including transfusion-dependent beta-thalas…
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia
This clinical trial update explains efforts to improve the scientific rigor of renal endpoints in sickle cell disease trials, including comp…
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients With Sickle Cell Disease Who Are at Increased Risk for Primary Stroke [Phase 2]
Phase 2 open-label trial evaluating etavopivat's effect on transcranial Doppler velocities in pediatric sickle cell patients at high risk fo…
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease [NA]
Clinical trial update notes ongoing study on using virtual reality technology to manage pain during vaso-occlusive crises in sickle cell dis…
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: Pharmacokinetics, Efficacy and Safety of Twice Daily Dosing Regimen of Hydroxycarbamide Dispersible Tablets in Children With Sickle Cell Disease [Phase 2]
Phase 2 trial to assess pharmacokinetics, efficacy, and safety of twice-daily hydroxycarbamide dispersible tablets in children with sickle c…
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CLINICAL_TRIALS trial_result · 2025-09-16Clinical Trial Update: Safety of Blood Stem Cell Mobilization With Plerixafor in Patients With Sickle Cell Disease [Phase 1]
Phase 1 safety update on using Plerixafor to mobilize blood stem cells in patients with Sickle Cell Disease; the study is active but not rec…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin [Phase 2]
A Phase 2 clinical trial evaluating empagliflozin, an SGLT2 inhibitor, for sickle cell–related kidney disease in patients with sickle cell a…
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CLINICAL_TRIALS trial_result · 2025-09-16Clinical Trial Update: Observational Prospective Study Measuring the Impact of the Use of a Hypnotic Script Associated With Virtual Reality on the Pain of the Child's Sickle Cell During a Vaso-occlusive Crisis [NA]
This is an observational prospective study evaluating whether a hypnotic script combined with virtual reality reduces pain in pediatric sick…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Identifying Barriers and Strategies to Support Self-efficacy for Medication Adherence With Text Messaging
The Vanderbilt University study investigates barriers to medication adherence in sickle cell disease and tests text-message–based strategies…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Effectiveness of Nontraditional Hydroxyurea Algorithms: Novel and Clinical Evaluations (ENHANCE) [Phase 4]
Phase 4 clinical trial evaluating nontraditional hydroxyurea treatment algorithms for sickle cell disease. The study is currently recruiting…
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CLINICAL_TRIALS trial_result · 2025-09-12Clinical Trial Update: A Study to Assess the Safety, Tolerability, and Efficacy of BIVV003 for Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Sickle Cell Disease [Phase 1, Phase 2]
This update reports the completion of a Phase 1/2 study evaluating the safety, tolerability, and efficacy of BIVV003 in autologous hematopoi…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Cerebral Oxygen Metabolism in Children [NA]
This clinical trial update indicates a study on cerebral oxygen metabolism in children is currently recruiting, sponsored by Washington Univ…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Transfusion Exchanges and Cognition in Sickle Cell Disease
A clinical trial investigating transfusion exchange procedures and cognitive outcomes in sickle cell disease; the study is currently not yet…
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CLINICAL_TRIALS trial_result · 2025-09-08Clinical Trial Update: Prognostic Factors of Acute Splenic Sequestration [NA]
A completed clinical trial update investigating prognostic factors for acute splenic sequestration in sickle cell disease.
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CLINICAL_TRIALS trial_result · 2025-09-05Clinical Trial Update: Assessment of Tolerance of Mobilizing Peripheral Hematopoietic Stem Cells by Plerixafor in Sickle Cell Patients [Phase 1, Phase 2]
Phase 1/2 trial assessing tolerance of mobilizing peripheral hematopoietic stem cells using plerixafor in patients with sickle cell disease …
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: Stroke Prevention in Young Adults With Sickle Cell Anemia
Clinical trial status update for a study evaluating stroke prevention in young adults with sickle cell anemia.
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: Metabolic and Hemodynamic Reserve in Pediatric SCA [NA]
This clinical trial update indicates that a study on metabolic and hemodynamic reserve in pediatric sickle cell disease is currently recruit…
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: HLA Haploidentical Bone Marrow Transplant in Patients With Severe Sickle Cell Disease [Phase 2]
This clinical trial update notes the completion of a Phase 2 study evaluating HLA haploidentical bone marrow transplant in patients with sev…
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CLINICAL_TRIALS research · 2025-09-02Clinical Trial Update: Awake Prone Positioning for Severe Acute Chest Syndrome [NA]
Trial NCT06698120 is evaluating awake prone positioning for severe Acute Chest Syndrome in sickle cell disease. The study is not yet recruit…
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CLINICAL_TRIALS trial_result · 2025-08-26Clinical Trial Update: A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD). [Phase 1]
Phase 1 study evaluating safety, pharmacokinetics, pharmacodynamics, and efficacy of Crovalimab for the management of acute uncomplicated va…
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CLINICAL_TRIALS trial_result · 2025-08-24Clinical Trial Update: Sickle Cell Disease (SCD) Bone Pain Study [NA]
Clinical trial update from UC Davis on sickle cell disease-related bone pain; the study is active but not recruiting, with results posted in…