Sickle Cell Disease
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CLINICAL_TRIALS trial_result · 2025-03-24Clinical Trial Update: Combined Use of a Respiratory Broad Panel Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Hospitalized Sickle-cell Adults With Acute Chest Syndrome. [NA]
Completed clinical trial evaluating the combined use of a respiratory broad panel multiplex PCR and procalcitonin to reduce antibiotic expos…
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CLINICAL_TRIALS trial_result · 2025-03-20Clinical Trial Update: Long-term Follow-up of Subjects with Sickle Cell Disease Treated with Ex Vivo Gene Therapy
Long-term follow-up of subjects with Sickle Cell Disease treated with an ex vivo gene therapy; enrollment by invitation is ongoing.
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CLINICAL_TRIALS trial_result · 2025-03-11Clinical Trial Update: Efficacy and Safety of Rivipansel (GMI-1070) in the Treatment of Vaso-Occlusive Crisis in Hospitalized Subjects With Sickle Cell Disease [Phase 3]
A Phase 3 trial evaluating rivipansel (GMI-1070) for treating vaso-occlusive crisis in hospitalized patients with sickle cell disease has co…
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CLINICAL_TRIALS trial_result · 2025-03-11Clinical Trial Update: Efficacy and Safety of Tocilizumab for Acute Chest Syndrome Treatment in Patients With Sickle Cell Disease [Phase 3]
This Phase 3 clinical trial is evaluating the efficacy and safety of tocilizumab for treating acute chest syndrome in patients with sickle c…
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CLINICAL_TRIALS trial_result · 2025-03-10Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of Crizanlizumab in Sickle Cell Disease Related Priapism [Phase 2]
Phase 2 trial evaluating crizanlizumab for sickle cell disease-related priapism has completed, with results posted.
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CLINICAL_TRIALS trial_result · 2025-03-03Clinical Trial Update: Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies [NA]
A hematopoietic stem cell transplant trial for high-risk hemoglobinopathies has been terminated; the conditions studied include sickle cell …
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CLINICAL_TRIALS trial_result · 2025-02-19Clinical Trial Update: Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell Via Mobile Applications [NA]
A completed clinical trial tested a mobile app–based cognitive behavioral therapy plus real-time pain management for people with sickle cell…
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CLINICAL_TRIALS trial_result · 2025-02-18Clinical Trial Update: Study to Assess Efficacy and Safety of VIT-2763 (Vamifeport) in Subjects With Sickle Cell Disease [Phase 2]
Phase 2 trial evaluating the efficacy and safety of vamifeport (VIT-2763) in sickle cell disease has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-02-14Clinical Trial Update: COVID-19 Vaccine Response in Sickle Cell Disease
A completed clinical trial evaluated the immune response to a COVID-19 vaccine in people with Sickle Cell Disease; results were posted on 20…
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CLINICAL_TRIALS trial_result · 2025-02-04Clinical Trial Update: Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH) [Phase 3]
A Phase 3 trial evaluating the efficacy and safety of bosentan in sickle cell disease patients with pulmonary arterial hypertension was term…
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CLINICAL_TRIALS trial_result · 2025-02-04Clinical Trial Update: Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients Diagnosed With Pulmonary Hypertension (PH) [Phase 3]
Phase 3 trial evaluating Bosentan in sickle cell disease patients with pulmonary hypertension was terminated, with the update focusing on ef…
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CLINICAL_TRIALS trial_result · 2025-01-31Clinical Trial Update: A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY) [Phase 1, Phase 2]
This document provides an update on RUBY, a Phase 1/2 clinical trial evaluating EDIT-301 for severe sickle cell disease, focusing on safety …
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CLINICAL_TRIALS trial_result · 2025-01-29Clinical Trial Update: Evaluation of Impact of Disease on Quality of Life, Education and Socio-professional Integration of Adults and Parents of Children Living with Sickle- Cell Disease in France
This completed clinical trial in France evaluated how sickle cell disease affects quality of life, education, and socio-professional integra…
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CLINICAL_TRIALS trial_result · 2025-01-27Clinical Trial Update: Steroid Injection for Sickle Cell Arthropathy Pain Therapy
A completed clinical trial evaluating the use of corticosteroid injections to treat pain associated with sickle cell arthropathy.
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CLINICAL_TRIALS trial_result · 2025-01-24Clinical Trial Update: Sleep and Pain in Sickle Cell Disease [NA]
A clinical trial examining sleep and pain in sickle cell disease has completed.
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CLINICAL_TRIALS trial_result · 2025-01-13Clinical Trial Update: Safety, Efficacy, Pharmacokinetic, and Pharmacodynamic Study of ALXN1820 in Adult Participants With Sickle Cell Disease [Phase 2]
Phase 2 clinical trial evaluating safety, efficacy, pharmacokinetics, and pharmacodynamics of ALXN1820 in adults with sickle cell disease; t…
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CLINICAL_TRIALS trial_result · 2025-01-09Clinical Trial Update: Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE) [Phase 3]
Phase 3 trial update (PIPSICKLE) evaluating low-dose aspirin to prevent intrauterine growth restriction and preeclampsia in pregnancies affe…
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CLINICAL_TRIALS trial_result · 2025-01-08Clinical Trial Update: An Indian Multi-centric Phase IV Study to Assess the Safety of Crizanlizumab in Sickle Cell Disease Patients [Phase 4]
Phase IV multicenter Indian study evaluating the safety of crizanlizumab in sickle cell disease has completed with results posted.
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CLINICAL_TRIALS trial_result · 2025-01-08Clinical Trial Update: A GBT021601 ADME Microtracer Study in Healthy Volunteers [Phase 1]
Pfizer completed a Phase 1 ADME microtracer study of GBT021601 in healthy volunteers; results have been posted.
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CLINICAL_TRIALS trial_result · 2024-12-24Clinical Trial Update: COVID-19 Vaccination Hesitancy in Adults With Sickle Cell Disease [NA]
A completed clinical trial update from Duke University examining COVID-19 vaccination hesitancy among adults with Sickle Cell Disease (NCT05…
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CLINICAL_TRIALS trial_result · 2024-12-19Clinical Trial Update: Haploidentical Hematopoietic Stem Cell Transplantation [Phase 1]
Phase 1 trial update reports the completion of a haploidentical hematopoietic stem cell transplantation study led by Catherine Bollard, inve…
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CLINICAL_TRIALS trial_result · 2024-12-19Clinical Trial Update: Exploration of the Parameters Influencing the Effort Limitation of Patients Suffering From Homozygous Sickle Cell Anemia
A completed clinical trial from Assistance Publique - Hôpitaux de Paris investigating factors that limit exercise capacity in patients with …
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CLINICAL_TRIALS trial_result · 2024-12-18Clinical Trial Update: Longitudinal Changes in Exercise Capacity in Children and Young Adults With Sickle Cell Anemia
This clinical trial update reports on longitudinal changes in exercise capacity among children and young adults with sickle cell disease and…
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CLINICAL_TRIALS trial_result · 2024-12-18Clinical Trial Update: Sickle Cell Pro-Inflammatory Response to Interval Training Study
The clinical trial investigating the pro-inflammatory response to interval training in sickle cell disease has completed.
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CLINICAL_TRIALS trial_result · 2024-12-13Clinical Trial Update: Building Adaptive Coping and Knowledge to Improve Daily Life [NA]
A clinical trial investigating an adaptive coping and knowledge program for individuals with Sickle Cell Disease has completed, with results…