Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease [Phase 2]
Phase 2 pediatric pharmacokinetics and safety study of etavopivat in sickle cell disease; currently recruiting.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease [Phase 3]
Phase 3 clinical trial evaluating etavopivat for sickle cell disease is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: School Readiness Intervention for Preschool Children With Sickle Cell Disease [NA]
A clinical trial at St. Jude Children's Research Hospital is recruiting preschool children with Sickle Cell Disease to evaluate a school rea…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease
This clinical trial update describes investigations into the mechanistic effects of mitapivat in subjects with sickle cell disease, which is…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
A clinical trial update describes development of non-invasive prenatal diagnosis for single-gene disorders. The study, based in Paris, is cu…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD) [Phase 2]
This clinical trial update describes a Phase 2 dose-finding study to evaluate the efficacy and safety of tebapivat in participants with sick…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease [Phase 1]
This is a Phase 1 clinical trial evaluating methylphenidate for attention and executive function deficits in children with sickle cell disea…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP) [Phase 2, Phase 3]
This document provides a clinical trial update on the Phase 2/Phase 3 study evaluating Mitapivat (AG-348) in participants with Sickle Cell D…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Autologous Testicular Tissue Transplantation [NA]
Recruitment is ongoing for an autologous testicular tissue transplantation trial addressing cancer and hematologic diseases, including sickl…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Exploring Adherence Monitoring in Sickle Cell Disease
Clinical trial update on adherence monitoring in sickle cell disease; the study is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Empowering Adolescents and Young Adults With Sickle Cell Disease as Partners in Treatment Decision Making (EMPOWER-AYA) [NA]
Clinical trial EMPOWER-AYA aims to involve adolescents and young adults with sickle cell disease in treatment decisions and shared decision-…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies
An observational study to deeply phenotype major organs in people with sickle cell disease after curative therapies, aiming to characterize …
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Pharmacogenetics and Model-Informed Optimisation of Hydroxyurea
Clinical trial exploring pharmacogenetics and model-informed optimization of hydroxyurea for sickle cell disease; status indicates not yet r…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: ATHNdataset Registry
The ATHNdataset Registry is currently recruiting participants; sponsored by the American Thrombosis and Hemostasis Network, the registry cov…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Realizing Effectiveness Across Continents With Hydroxyurea [Phase 2]
Phase 2 clinical trial of hydroxyurea for sickle cell disease in children is active but not recruiting.
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Sickle Cell Children's Exercise Study (SuCCESs) [NA]
This clinical trial update indicates that the Sickle Cell Children's Exercise Study (SuCCESs) sponsored by the University of Maryland is cur…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease [Phase 1]
This is a Phase 1 clinical trial update evaluating haploidentical hematopoietic stem cell transplantation with pre-transplant immunosuppress…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
NIAID-sponsored clinical trial update indicates recruitment is ongoing to collect human biospecimens for basic and clinical research into gl…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Development of a Provider-Focused Intervention to Improve Health Outcomes in Pediatric Sickle Cell Disease [NA]
A clinical trial update describing the development of a provider-focused intervention to improve health outcomes for pediatric sickle cell d…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Solving Stigma Through POV Simulation: Enhancing Pharmacist Empathy-based Practices With Sickle Cell Disease Patients [NA]
This clinical trial update notes enrollment for a study using point-of-view simulation to improve pharmacists' empathy toward patients with …
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
A clinical trial evaluating dietary intake and dietary behaviors in adults with sickle cell disease, currently recruiting at the NIH Clinica…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating transplantation of CRISPR-modified hematopoietic progenitor stem cells (CRISPR_SCD001) in patients …
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Developing the Family Map: Looking at Communal Coping
NHGRI-funded clinical trial update on the Developing the Family Map study, examining communal coping, which has completed; conditions involv…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis [Phase 2]
Phase 2 clinical trial evaluating safety, efficacy, and pharmacokinetics of CSL889 in adults and adolescents with sickle cell disease during…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease [Phase 3]
Sanofi is conducting a Phase 3 trial to evaluate a single-dose, 21-valent pneumococcal conjugate vaccine in children and adolescents with si…