Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-07-17Clinical Trial Update: Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE) [Phase 2]
SPHERE is a Phase 2 trial evaluating hydroxyurea to prevent stroke in children with sickle cell disease. Enrollment is by invitation and the…
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CLINICAL_TRIALS trial_result · 2025-07-15Clinical Trial Update: The Radiofrequency Therapy in Management of Sickle Cell Disease Chronic Pain RCT Tested the Effect of TECAR Therapy on Sickle Cell Disease Chronic Pain. [NA]
A completed clinical trial evaluated TECAR therapy (radiofrequency energy transfer) for chronic pain in patients with Sickle Cell Disease.
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CLINICAL_TRIALS trial_result · 2025-07-09Clinical Trial Update: Resolution of Sickle Cell Leg Ulcers With Voxelotor [Phase 3]
A Phase 3 trial of voxelotor for resolution of sickle cell leg ulcers has been terminated, and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-06-25Clinical Trial Update: Use of Macrolides in Acute Chest Syndrome: A Multicenter Retrospective Study
A multicenter retrospective study evaluates the use of macrolide antibiotics in acute chest syndrome among patients with sickle cell disease…
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: Hydroxyurea Optimization Through Precision Study [Phase 3]
A Phase 3 trial evaluating precision optimization of hydroxyurea for sickle cell disease has completed.
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: Effect of Virtual Reality on Pain and Function in Children With Sickle Cell Disease: A Randomized Controlled Trial [NA]
This randomized controlled trial assessed the effect of virtual reality on pain and function in children with sickle cell disease. The study…
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CLINICAL_TRIALS trial_result · 2025-06-13Clinical Trial Update: Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease [Phase 3]
Phase 3 pediatric study evaluating GBT440 (voxelotor) on transcranial Doppler in sickle cell disease was terminated; results have been poste…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: The Impact of Oxidative Stress on Erythrocyte Biology [Phase 2]
A Phase 2 trial examining the impact of oxidative stress on erythrocyte biology in sickle cell disease was terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2025-06-02Clinical Trial Update: CS-206 in Patients With Sickle Cell Disease [EARLY_Phase 1]
CS-206 is planned for an early Phase 1 trial in patients with Sickle Cell Disease and is currently not yet recruiting.
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Ketamine for Acute Painful Crisis in Sickle Cell Disease Patients [NA]
Clinical trial update reports that a study evaluating ketamine for acute painful crisis in sickle cell disease has completed enrollment and …
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: Shared-Decision Making for Hydroxyurea [NA]
Clinical trial update indicating that results from a hydroxyurea study in children with sickle cell anemia have been posted after completion…
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: A Study to Assess the Safety and Pharmacokinetics of HBI-002, an Oral Carbon Monoxide Therapeutic, in Healthy Volunteers [Phase 1]
Phase 1 study evaluating the safety and pharmacokinetics of HBI-002, an oral carbon monoxide–releasing therapeutic, in healthy volunteers; t…
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: Role of Inflammasome in Platelet Activation in Sickle Cell Disease Patient
A completed clinical trial examining the role of inflammasome activation in platelet activation among patients with sickle cell disease.
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease [Phase 2]
A Phase 2 clinical trial evaluating myeloablative conditioning, prophylactic defibrotide, and haploidentical allogeneic stem cell transplant…
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CLINICAL_TRIALS trial_result · 2025-05-14Clinical Trial Update: SIKAMIC (SIklos on Kidney Function and AlbuMInuria Clinical Trial) [Phase 2]
The Phase 2 trial of SIKAMIC for sickle cell disease, evaluating kidney function and albuminuria, has completed. Results were posted on 2025…
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CLINICAL_TRIALS trial_result · 2025-05-07Clinical Trial Update: Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers [Phase 2]
A Phase 2 trial evaluating topical sodium nitrite for sickle cell disease and leg ulcers was terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: RHD Genotype Matched Red Cells for Anti-D [EARLY_Phase 1]
Early Phase 1 trial evaluating RHD genotype-matched red blood cells to mitigate Anti-D antibody reactions in sickle cell disease; the study …
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507) [Phase 2]
Phase 2 trial update on haploidentical bone marrow transplantation for sickle cell disease. The study BMTCTN1507 sponsored by the Medical Co…
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CLINICAL_TRIALS trial_result · 2025-04-20Clinical Trial Update: Home-Based Intervention for Chronic Pain in Adults With Sickle Cell Disease [NA]
Completed clinical trial evaluating a home-based intervention to manage chronic pain in adults with sickle cell disease, with results posted…
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CLINICAL_TRIALS trial_result · 2025-04-17Clinical Trial Update: Hydroxyurea Therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda ( BRAINSAFE-II ) [Phase 3]
Completed Phase 3 trial (BRAINSAFE-II) evaluating hydroxyurea for neurological and cognitive protection in children with sickle cell disease…
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CLINICAL_TRIALS trial_result · 2025-04-17Clinical Trial Update: Interest of Nutritional Care of Children With Sickle Cell Disease on Bone Mineral Density and Body Composition [NA]
A completed clinical trial assessing whether nutritional care improves bone mineral density and body composition in children with sickle cel…
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CLINICAL_TRIALS trial_result · 2025-04-03Clinical Trial Update: A Voxelotor for Sickle Cell Anemia Patients at Highest Risk for Progression of Chronic Kidney Disease [Phase 1, Phase 2]
This clinical trial update reports termination of a Phase 1/2 study evaluating voxelotor (Oxbryta) in sickle cell disease patients at highes…
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: Escalation of Plerixafor for Mobilization of CD34+ Hematopoietic Progenitor Cells and Evaluation of Globin Gene Transfer in Patients With Sickle Cell Disease [Phase 1]
Phase 1 trial in sickle cell disease evaluates escalating doses of Plerixafor to mobilize CD34+ hematopoietic progenitor cells and assesses …
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: ORCHARD- Optimising Home Assessment of Rural Patients [NA]
ORCHARD, a trial on Optimising Home Assessment of Rural Patients, has completed; the update provides no trial results in this notice.
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CLINICAL_TRIALS trial_result · 2025-03-27Clinical Trial Update: Sickle Cell Hemoglobinopathies and Bone Health
Clinical trial update indicating that the Sickle Cell Hemoglobinopathies and Bone Health study sponsored by UConn Health is currently active…