Septic Shock
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock [Phase 3]
This update reports the completion of a Phase 3 trial evaluating early goal-directed therapy in prehospital care for patients with severe se…
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Predictive Mini-bolus Fluid Responsiveness in Pediatric Septic Shock [NA]
A completed pediatric septic shock trial evaluating predictive mini-bolus fluid responsiveness; the update does not report results.
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Usage of Glucose Fluctuations as a Prognostic Marker in Septic Shock Patients
A clinical trial from Assiut University is exploring whether fluctuations in blood glucose can serve as a prognostic marker in septic shock …
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CLINICAL_TRIALS trial_result · 2025-11-19Clinical Trial Update: Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock?
This completed clinical trial examined whether the timing of evaluating fluid challenges after vascular filling affects the measured respons…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study) [Phase 3]
Phase 3 randomized trial evaluating human albumin for resuscitation in surgical septic shock, sponsored by Mahidol University; status is not…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure [Phase 4]
Phase 4 clinical trial examining an educational intervention on immunosuppressive regimens for kidney transplant recipients admitted to the …
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Prospective Validation of Clini-biological Parameters Including Initial Hemostasis, Which Improve the Prediction of Death at 1 Month Among Patients With Septic Shock
This completed clinical trial prospectively validated clini-biological parameters, including initial hemostasis, to improve prediction of 1-…
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CLINICAL_TRIALS research · 2025-10-30Clinical Trial Update: Stress Hydrocortisone In Pediatric Septic Shock [Phase 3]
An ongoing Phase 3 clinical trial is evaluating stress-dose hydrocortisone in pediatric septic shock; the study is currently recruiting.
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CLINICAL_TRIALS research · 2025-10-21Clinical Trial Update: Vasopressin for Septic Shock Pragmatic Trial [Phase 4]
A Phase 4 pragmatic trial evaluating vasopressin for septic shock is currently active but not recruiting. The sponsor is Intermountain Healt…
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CLINICAL_TRIALS research · 2025-10-09Clinical Trial Update: Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy [Phase 2]
This Phase IIb multicenter randomized controlled trial is evaluating the efficacy of Sivelestat in patients with septic coagulopathy and is …
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CLINICAL_TRIALS trial_result · 2025-10-03Clinical Trial Update: Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis [Phase 1]
A Phase 1 clinical trial evaluating therapeutic plasma exchange in adults with septic shock has completed.
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room
Clinical trial sponsored by Amsterdam University Medical Centers aims to identify BIOmarkers to diagnose sepsis in the emergency department;…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections [Phase 3]
Phase 3 trial update evaluating the combination of ceftazidime and fosfomycin versus ceftazidime alone in hospitalized adults with suspected…
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CLINICAL_TRIALS trial_result · 2025-09-24Clinical Trial Update: Midodrine Use in Septic Shock [Phase 3]
A Phase 3 trial evaluating midodrine for septic shock was terminated; results were posted on 2025-09-24.
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CLINICAL_TRIALS trial_result · 2025-09-22Clinical Trial Update: Guiding Fluid Resuscitation in Septic Shock: Ultrasound vs. Noninvasive Cardiac Output Monitoring [NA]
A completed clinical trial comparing ultrasound-guided fluid resuscitation to noninvasive cardiac output monitoring in patients with septic …
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
A clinical trial update investigates nucleosome monitoring as a predictor of outcomes in critically ill patients, including sepsis, septic s…
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis [NA]
A pediatric clinical trial is actively recruiting to reduce empiric vancomycin use in suspected sepsis, including scenarios involving MRSA, …
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CLINICAL_TRIALS trial_result · 2025-09-19Clinical Trial Update: Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock [NA]
This clinical trial update reports the completion of a study evaluating guided fluid-balance optimization using mini-fluid challenges in sep…
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: Adaptive Blood Purification for the Treatment of Patients With Septic Shock [NA]
The document reports an ongoing clinical trial evaluating adaptive blood purification for septic shock, with enrollment by invitation curren…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Population-Based Analysis of Incidence and Mortality of Septic Shock
This clinical trial update reports a population-based analysis of incidence and mortality for septic shock.
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis [Phase 2]
Phase 2 randomized trial evaluating the use of Pentaglobin as personalized adjunct therapy after surgical source control in patients with pe…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: CytOSorb TreatMent Of Critically Ill PatientS Registry
A Clinical Trials registry update shows that CytoSorbents is recruiting for a registry trial evaluating Cytosorb hemoadsorption in criticall…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis
Clinical trial update describes a predictive model for multidrug resistance in patients with sepsis admitted from the emergency department. …
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CLINICAL_TRIALS trial_result · 2025-09-03Clinical Trial Update: GM-CSF to Decrease ICU Acquired Infections [Phase 3]
Phase 3 clinical trial evaluating GM-CSF to decrease ICU-acquired infections has completed in patients with septic shock and sepsis.
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CLINICAL_TRIALS trial_result · 2025-08-27Clinical Trial Update: Non-Invasive Cardiac Output Monitor (NICOM) for Goal-directed Fluid Resuscitation for Inpatients With Hypotension and/or Septic Shock [NA]
This is a clinical trial update evaluating the NICOM non-invasive cardiac output monitor for goal-directed fluid resuscitation in inpatients…