Sepsis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2020-07-30Clinical Trial Update: suPAR to Guide Antibiotics in Emergency Department [Phase 2, Phase 3]
Phase 2/3 trial investigating suPAR-guided antibiotics in emergency department for sepsis.
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CLINICAL_TRIALS trial_result · 2020-07-29Clinical Trial Update: A Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis [Phase 2]
Phase 2 clinical trial update for validation and restoration of immune dysfunction in severe infections and sepsis has completed.
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CLINICAL_TRIALS trial_result · 2020-07-09Clinical Trial Update: A Study of IL-7 to Restore Absolute Lymphocyte Counts in Sepsis Patients [Phase 2]
Phase 2 trial evaluating IL-7 to restore absolute lymphocyte counts in patients with severe sepsis and septic shock; study completed with re…
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CLINICAL_TRIALS trial_result · 2020-06-18Clinical Trial Update: Effect of Emergency Department Care Reorganization on Door-to-antibiotic Times for Sepsis (LDS SWARM)
A completed trial assessing how emergency department care reorganization affected door-to-antibiotic times in sepsis and septic shock.
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FDA label_change · 2020-05-26FDA Approved: ZOSYN IN GALAXY CONTAINERS — Supplemental Application (Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.)
FDA approved a supplemental application for ZOSYN in Galaxy containers, a packaging/labeling change for the piperacillin/tazobactam product.…
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CLINICAL_TRIALS trial_result · 2020-04-27Clinical Trial Update: Prophylactic Probiotics to Extremely Low Birth Weight Prematures [Phase 2]
Phase 2 trial of prophylactic probiotics in extremely low birth weight preterm infants completed; results have been posted.
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CLINICAL_TRIALS trial_result · 2020-04-22Clinical Trial Update: Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit [NA]
Completed pediatric ICU trial evaluating procalcitonin-based testing and treatment algorithm to reduce antibiotic use and influence outcomes…
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CLINICAL_TRIALS trial_result · 2020-04-21Clinical Trial Update: Phase 3 Safety and Efficacy Study of ART-123 in Subjects With Severe Sepsis and Coagulopathy [Phase 3]
Phase 3 trial assessing ART-123 in adults with severe sepsis and coagulopathy has completed; results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-03-13Clinical Trial Update: Efficacy and Pharmacokinetics of Meropenem in Severe Septic Patients [Phase 4]
Phase 4 trial update evaluating efficacy and pharmacokinetics of meropenem in severe septic patients.
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CLINICAL_TRIALS trial_result · 2020-03-03Clinical Trial Update: Evolocumab for PCSK9 Lowering in Early Acute Sepsis (The PLEASe Study) [Phase 2]
A Phase 2 clinical trial update investigating evolocumab for PCSK9 lowering in early acute sepsis (PLEASe Study).
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CLINICAL_TRIALS trial_result · 2020-03-02Clinical Trial Update: Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure [Phase 4]
Phase 4 trial update on sedative medications in patients with sepsis and respiratory failure, including agitation management; results posted…
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CLINICAL_TRIALS trial_result · 2020-02-24Clinical Trial Update: Antibiotic/COPD in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Requiring Mechanical Ventilation [Phase 3]
Phase 3 trial in COPD patients with acute exacerbation requiring mechanical ventilation evaluated an antibiotic regimen; study completed.
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CLINICAL_TRIALS trial_result · 2020-02-21Clinical Trial Update: Efficacy and Safety of Rheosorbilact® Solution for Infusion, in a Complex Therapy of Sepsis. [Phase 4]
Phase 4 trial update evaluating the efficacy and safety of Rheosorbilact® Solution for infusion as part of complex therapy for sepsis.
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CLINICAL_TRIALS trial_result · 2020-01-13Clinical Trial Update: Evaluating Muscle Weakness Improvement With Lorcaserin in ICU [Phase 1, Phase 2]
A phase 1/2 trial evaluating lorcaserin for muscle weakness in ICU patients with sepsis was terminated; results have been posted.
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CLINICAL_TRIALS trial_result · 2019-12-06Clinical Trial Update: Vitamin C, Vitamin B1 and Steroid in Sepsis [Phase 4]
Phase 4 clinical trial update investigating the use of vitamin C, vitamin B1, and a steroid for sepsis and severe sepsis.
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CLINICAL_TRIALS trial_result · 2019-11-01Clinical Trial Update: A Randomized Controlled Trial of a Conservative Fluid Balance Strategy for Patients With Sepsis and Cardiopulmonary Dysfunction (BALANCE Study) [NA]
A randomized controlled trial evaluating a conservative fluid balance strategy in patients with sepsis and cardiopulmonary dysfunction; stud…
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CLINICAL_TRIALS trial_result · 2019-10-28Clinical Trial Update: Antibiotic Prophylaxis in Patients Undergoing GVO [Phase 4]
Phase 4 clinical trial updating antibiotic prophylaxis for patients undergoing GVO (gastric variceal obliteration) with conditions including…
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CLINICAL_TRIALS trial_result · 2019-10-15Clinical Trial Update: Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury [Phase 2]
Phase 2 trial update for vitamin C infusion in sepsis-induced acute lung injury has completed with results posted.
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CLINICAL_TRIALS trial_result · 2019-10-10Clinical Trial Update: The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial [Phase 2]
Phase 2 trial update for a vitamin C, hydrocortisone, and thiamine regimen in septic shock patients; study completed.
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CLINICAL_TRIALS trial_result · 2019-09-17Clinical Trial Update: Rapid Atrial Fibrillation Treatment Strategy [Phase 4]
Phase 4 clinical trial update investigating a rapid treatment strategy for new-onset atrial fibrillation in hospitalized patients, including…
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CLINICAL_TRIALS withdrawal · 2019-09-13Clinical Trial Update: The Safety And Efficacy of ART-123 in Subjects With Sepsis and Coagulopathy [Phase 3]
Phase 3 trial of ART-123 in sepsis and coagulopathy was withdrawn from status.
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CLINICAL_TRIALS trial_result · 2019-08-05Clinical Trial Update: Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study [Phase 1]
A Phase 1 pilot feasibility trial comparing balanced versus normal saline fluids for pediatric sepsis conducted, completed with results post…
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CLINICAL_TRIALS trial_result · 2019-07-08Clinical Trial Update: Effect of Different Electric Muscle Stimulation in Patients With Severe Sepsis and Respiratory Failure [NA]
Clinical trial investigating different electric muscle stimulation in patients with severe sepsis and respiratory failure; study terminated …
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CLINICAL_TRIALS trial_result · 2019-05-03Clinical Trial Update: Zambia Chlorhexidine Application Trial [Phase 2, Phase 3]
Phase 2/3 clinical trial investigating chlorhexidine application for sepsis has completed; results posted in 2019.
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CLINICAL_TRIALS trial_result · 2019-04-04Clinical Trial Update: Efficacy of Thymosin Alpha 1 on Improving Monocyte Function for Sepsis [Phase 4]
Phase 4 clinical trial evaluating thymosin alpha-1 for improving monocyte function in sepsis has completed.