Sepsis
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CLINICAL_TRIALS trial_result · 2019-04-04Clinical Trial Update: A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock. [Phase 1]
Phase 1 trial evaluating safety and pharmacokinetics of nivolumab in patients with severe sepsis or septic shock; study completed with resul…
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CLINICAL_TRIALS trial_result · 2019-04-02Clinical Trial Update: Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock [Phase 4]
Phase 4 trial update on using amiodarone for atrial fibrillation in patients with severe sepsis or septic shock; the study is terminated wit…
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CLINICAL_TRIALS trial_result · 2019-03-15Clinical Trial Update: Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants [Phase 3]
Phase 3 trial evaluating fat-soluble vitamin supplementation effects on complications and neural development in very low birth weight infant…
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CLINICAL_TRIALS trial_result · 2019-03-04Clinical Trial Update: The Effect of Dexmedetomidine on Microcirculation in Severe Sepsis [Phase 4]
Phase 4 clinical trial investigating the effect of Dexmedetomidine on microcirculation in severe sepsis; the study was terminated.
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CLINICAL_TRIALS trial_result · 2019-02-22Clinical Trial Update: Efficacy and Safety Study of CA330 Hemoadsorption Device on IL-6 Removal in Septic Patients [NA]
This entry provides an update on a clinical trial evaluating the CA330 Hemoadsorption Device for IL-6 removal in septic patients, focusing o…
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CLINICAL_TRIALS trial_result · 2019-02-19Clinical Trial Update: The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock [Phase 4]
A Phase 4 terminated clinical trial evaluating whether the combination of vitamin C, thiamine, and hydrocortisone affects the clinical cours…
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CLINICAL_TRIALS research · 2019-02-18Clinical Trial Update: Therapeutic Plasma Exchange in the Treatment of Sepsis Associated Multi-Organ Failure [SAMOF-TPE] [NA]
A clinical trial update investigating Therapeutic Plasma Exchange for sepsis-associated multi-organ failure (SAMOF-TPE) with the sponsor For…
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CLINICAL_TRIALS research · 2019-02-15Clinical Trial Update: Metabolism of Branched-chain Amino Acids in Monocyte/Macrophage During Sepsis
This clinical trial investigates how branched-chain amino acid metabolism in monocytes and macrophages changes during sepsis. The study aims…
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CLINICAL_TRIALS research · 2019-02-11Clinical Trial Update: Blood Lactate Level for Pre-hospital Orientation of Septic Shock
A clinical trial update evaluating whether blood lactate levels can guide pre-hospital assessment and management of septic shock.
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CLINICAL_TRIALS research · 2019-02-06Clinical Trial Update: Implementation of a Web Based Real Time Clinical Decision Support Tool. [NA]
A completed Mayo Clinic trial reports on implementing a web-based real-time clinical decision support tool for managing critical illness and…
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CLINICAL_TRIALS trial_result · 2019-01-31Clinical Trial Update: Novel Device for Rapid Fluid Administration [NA]
A completed Yale University clinical trial evaluated a novel device for rapid fluid administration in sepsis, with results posted in 2019.
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CLINICAL_TRIALS research · 2019-01-29Clinical Trial Update: Quantification of Bacterial DNA in Sepsis
This entry reports on a clinical trial studying quantification of bacterial DNA in patients with sepsis and septic shock; the current status…
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CLINICAL_TRIALS trial_result · 2019-01-28Clinical Trial Update: Following of Myeloid-derived Suppressor Cells (MDSC) in Severe Sepsis: What Relationship With Systemic Inflammatory Syndrome?
The clinical trial investigating myeloid-derived suppressor cells in severe sepsis and their relationship to systemic inflammatory syndrome …
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CLINICAL_TRIALS trial_result · 2019-01-22Clinical Trial Update: Feeding Bovine Colostrum to Preterm Infants [NA]
A completed clinical trial evaluated feeding bovine colostrum in preterm infants with outcomes including feeding intolerance and extrauterin…
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CLINICAL_TRIALS trial_result · 2019-01-03Clinical Trial Update: Changes in Exhaled 13CO2/12CO2 Breath Delta Value as an Early Indicator of Infection in ICU Patients [NA]
Clinical trial update on exhaled 13CO2/12CO2 breath delta as an early indicator of infection in ICU patients with sepsis; study status compl…
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CLINICAL_TRIALS trial_result · 2018-10-23Clinical Trial Update: Control Versus Liberal Cardiac Frequency in Patients in Sepse With Atrial Fibrillation of High Ventricular Response [Phase 3]
Phase 3 clinical trial comparing control versus liberal heart rate strategies in septic patients with atrial fibrillation and high ventricul…
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CLINICAL_TRIALS trial_result · 2018-10-12Clinical Trial Update: S.A.F.E.BT System Extracorporeal Treatment With DIAPACT CRRT [NA]
Clinical trial update indicating termination of the S.A.F.E.BT System Extracorporeal Treatment with DIAPACT CRRT in severe sepsis; results p…
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CLINICAL_TRIALS trial_result · 2018-08-29Clinical Trial Update: Fluids in Sepsis and Septic Shock [Phase 2, Phase 3]
Phase 2/3 clinical trial update on fluids used for sepsis and septic shock; status completed.
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CLINICAL_TRIALS trial_result · 2018-08-16Clinical Trial Update: Treatment of Severe Infection With Antihyperlipidemia Drug [Phase 2, Phase 3]
Clinical trial update for an antihyperlipidemia drug being tested for severe infection in Phase 2/Phase 3.
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FDA approval · 2018-08-10FDA Approved: PIPERACILLIN AND TAZOBACTAM — Original Application (Shandong Anxin Pharmaceutical Co., Ltd.)
FDA approved the original application for a generic Piperacillin and Tazobactam combination from Shandong Anxin Pharmaceutical Co., Ltd., ex…
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CLINICAL_TRIALS trial_result · 2018-08-07Clinical Trial Update: A Study of LJPC-501 in Pediatric Patients With Hypotension [Phase 2]
Phase 2 trial update for LJPC-501 in pediatric patients with catecholamine-resistant hypotension completed.
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CLINICAL_TRIALS research · 2018-07-26Clinical Trial Update: Derivation and Validation of a Prognostic Model for Septic Patients at Hospital Admission
This clinical trial update describes the derivation and validation of a prognostic model to predict outcomes for septic patients at hospital…
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CLINICAL_TRIALS trial_result · 2018-07-24Clinical Trial Update: Doppler Ultrasound for Prediction of Reversibility of Acute Kidney Injury in Septic ICU Patients
A completed clinical trial evaluated whether Doppler ultrasound measurements can predict reversibility of acute kidney injury in septic ICU …
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CLINICAL_TRIALS research · 2018-07-18Clinical Trial Update: Application of Biomarkers Change to Predict Outcome of Patient With Severe Sepsis
This clinical trial update describes a study on applying biomarker changes to predict outcomes in patients with severe sepsis.
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CLINICAL_TRIALS trial_result · 2018-07-18Clinical Trial Update: Systems Biology Approach to Cognitive Impairment After SepsiS
A completed clinical trial investigating a systems biology approach to cognitive impairment following sepsis.