Progressive Multiple Sclerosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2019-02-20Clinical Trial Update: Mitochondrial Dysfunction and Disease Progression
A completed clinical trial (NCT02549703) examining the role of mitochondrial dysfunction in disease progression across multiple sclerosis fo…
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CLINICAL_TRIALS trial_result · 2018-11-02Clinical Trial Update: A Phase 2 Clinical Study in Subjects With Primary Progressive Multiple Sclerosis to Assess the Efficacy, Safety and Tolerability of Two Oral Doses of Laquinimod Either of 0.6 mg/Day or 1.5mg/Day (Experimental Drug) as Compared to Placebo [Phase 2]
Phase 2 trial evaluating two doses of laquinimod (0.6 mg/day and 1.5 mg/day) versus placebo for primary progressive multiple sclerosis; stud…
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CLINICAL_TRIALS trial_result · 2018-10-31Clinical Trial Update: Exploring the Efficacy and Safety of Siponimod in Patients With Secondary Progressive Multiple Sclerosis (EXPAND) [Phase 3]
This update reports results from the Phase 3 EXPAND trial evaluating siponimod for secondary progressive multiple sclerosis, including asses…
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CLINICAL_TRIALS trial_result · 2018-06-11Clinical Trial Update: Evaluation of the Incidence of Relapses in Patients With Biotin-treated Progressive Multiple Sclerosis
This document provides an update on a clinical trial evaluating the incidence of relapses in patients with progressive multiple sclerosis tr…
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CLINICAL_TRIALS trial_result · 2017-12-26Clinical Trial Update: A Study of Ocrelizumab in Participants With Primary Progressive Multiple Sclerosis [Phase 3]
Phase 3 trial update for ocrelizumab in primary progressive multiple sclerosis has completed with results posted.
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CLINICAL_TRIALS trial_result · 2017-10-25Clinical Trial Update: The Effect of High Intensity Interval Training on Cardiovascular Fitness in People With Progressive Multiple Sclerosis. [NA]
This completed clinical trial evaluated the impact of high-intensity interval training on cardiovascular fitness in people with progressive …
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CLINICAL_TRIALS trial_result · 2017-08-30Clinical Trial Update: A Phase 1 Trial of Intrathecal Rituximab for Progressive Multiple Sclerosis Patients [Phase 1]
This update reports the completion of a Phase 1 trial evaluating intrathecal rituximab in patients with progressive multiple sclerosis (prim…
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CLINICAL_TRIALS trial_result · 2017-07-14Clinical Trial Update: Safety and Efficacy Study of MIS416 to Treat Secondary Progressive Multiple Sclerosis [Phase 2]
Phase 2 safety and efficacy results for MIS416 in secondary progressive multiple sclerosis have been reported. The study was sponsored by In…
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Treating New Learning and Memory Deficits in Progressive Multiple Sclerosis (MS) [NA]
This update reports the completion of a clinical trial focused on treating learning and memory deficits in progressive multiple sclerosis.
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CLINICAL_TRIALS trial_result · 2017-06-27Clinical Trial Update: A Clinical Study of the Efficacy of Natalizumab on Reducing Disability Progression in Participants With Secondary Progressive Multiple Sclerosis [Phase 3]
Phase 3 clinical trial evaluating natalizumab for reducing disability progression in secondary progressive multiple sclerosis; study termina…
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CLINICAL_TRIALS trial_result · 2017-06-14Clinical Trial Update: This Was an Open-label, Single-arm Extension Study (CFTY720D2306E1) to a Double-blind, Randomized Multicenter, Placebo-controlled, Parallel-group Core Study (CFTY720D2306) in PPMS. [Phase 3]
Open-label extension of a double-blind, randomized Phase 3 core study in primary progressive multiple sclerosis; the trial was terminated an…
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CLINICAL_TRIALS trial_result · 2017-03-21Clinical Trial Update: A Safety and Efficacy Study of Oral Prolonged-Release Fampridine (BIIB041) in Japanese Participants With Multiple Sclerosis [Phase 3]
Phase 3 trial evaluating oral prolonged-release dalfampridine (BIIB041) for safety and efficacy in Japanese participants with multiple scler…
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CLINICAL_TRIALS trial_result · 2017-01-11Clinical Trial Update: Dose-Escalation Study of T Cell Vaccine in Multiple Sclerosis [Phase 1, Phase 2]
An update on a dose-escalation Phase 1/2 trial of Opexa's autologous T cell vaccine for relapsing-remitting and secondary progressive multip…
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CLINICAL_TRIALS trial_result · 2017-01-10Clinical Trial Update: Study of Tcelna (Imilecleucel-T) in Secondary Progressive Multiple Sclerosis [Phase 2]
This update reports the Phase 2 clinical trial of Imilecleucel-T (Tcelna) for secondary progressive multiple sclerosis, which has completed …
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CLINICAL_TRIALS trial_result · 2016-11-22Clinical Trial Update: Intrathecal Therapy With Monoclonal Antibodies in Progressive Multiple Sclerosis [Phase 2]
Clinical trial update indicating that a Phase 2 intrathecal monoclonal antibody therapy study in progressive multiple sclerosis has complete…
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CLINICAL_TRIALS trial_result · 2016-11-09Clinical Trial Update: A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple Sclerosis
This update reports the results of a pilot study evaluating microRNA biomarkers in early and later stages of multiple sclerosis.
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CLINICAL_TRIALS trial_result · 2016-09-20Clinical Trial Update: Tear Analysis in the Diagnosis of Multiple Sclerosis [NA]
A study evaluating tear analysis as a diagnostic method for Primary Progressive Multiple Sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2016-05-13Clinical Trial Update: Access, Use and Opinions of Physiotherapy and Rehabilitation Services of People With Progressive MS in the UK.
A completed clinical trial assessing access, use, and opinions of physiotherapy and rehabilitation services for people with Progressive Mult…
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CLINICAL_TRIALS trial_result · 2016-04-13Clinical Trial Update: A First-in-human, Single Ascending Dose Study of GZ402668 in Patients With Progressive Multiple Sclerosis [Phase 1]
This first-in-human, single ascending-dose Phase 1 trial of GZ402668 in patients with progressive multiple sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2016-03-30Clinical Trial Update: Autologous Mesenchymal Stem Cell (MSC) Transplantation in MS [Phase 1]
This Phase 1 study evaluates autologous mesenchymal stem cell transplantation in people with relapsing-remitting, secondary progressive, or …
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CLINICAL_TRIALS trial_result · 2015-09-09Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of Rituximab in Adults With Primary Progressive Multiple Sclerosis [Phase 2, Phase 3]
A Phase 2/3 study evaluating rituximab for safety and efficacy in adults with primary progressive multiple sclerosis has completed, with res…
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CLINICAL_TRIALS trial_result · 2014-10-27Clinical Trial Update: Efficacy, Safety and Tolerability of Andrographolides Versus Placebo in Patients With Progressive Forms of MS [Phase 1, Phase 2]
Clinical trial update evaluating the efficacy, safety and tolerability of andrographolide versus placebo in progressive forms of multiple sc…
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CLINICAL_TRIALS trial_result · 2014-09-09Clinical Trial Update: Safety Study of Natalizumab to Treat Multiple Sclerosis (MS) [Phase 1]
Phase 1 safety study of Natalizumab in multiple sclerosis has completed. The update highlights safety and tolerability data from this early-…
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CLINICAL_TRIALS trial_result · 2014-02-11Clinical Trial Update: Hydroxyurea in Primary Progressive Multiple Sclerosis [Phase 2, Phase 3]
A Phase 2/3 clinical trial evaluating hydroxyurea for primary progressive multiple sclerosis was terminated (status: TERMINATED).
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CLINICAL_TRIALS trial_result · 2013-07-11Clinical Trial Update: Cyclic Oral Methylprednisolone Trial in Multiple Sclerosis [Phase 2]
Phase 2 trial of cyclic oral methylprednisolone for progressive multiple sclerosis has completed enrollment/status.