Progressive Multiple Sclerosis
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CLINICAL_TRIALS research · 2025-10-31Clinical Trial Update: RESET-MS: A Study to Evaluate the Safety and Efficacy of CABA-201 in Participants With Multiple Sclerosis [Phase 1, Phase 2]
Clinical trial update for RESET-MS, a Phase 1/Phase 2 study evaluating CABA-201 in relapsing-remitting and progressive multiple sclerosis, w…
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CLINICAL_TRIALS research · 2025-10-30Clinical Trial Update: A Study of Remibrutinib Using MR Imaging in Relapsing or Progressive MS [Phase 2]
This clinical trial update describes a Phase 2 study of remibrutinib using magnetic resonance imaging in relapsing-remitting, secondary prog…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Serum Neurofilaments and GFAP in Atypical Multiple Sclerosis [NA]
This clinical trial update reports measurements of serum neurofilaments and GFAP in patients with relapsing-remitting and progressive multip…
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CLINICAL_TRIALS research · 2025-09-12Clinical Trial Update: Masitinib in the Treatment of Patients With Primary Progressive or Non-active Secondary Progressive Multiple Sclerosis [Phase 3]
Phase 3 trial update for masitinib in primary progressive or non-active secondary progressive multiple sclerosis, currently ACTIVE_NOT_RECRU…
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CLINICAL_TRIALS research · 2025-09-04Clinical Trial Update: SIZOMUS Safety of Ixazomib Targeting Plasma Cells in Multiple Sclerosis [Phase 1]
Phase 1 clinical trial evaluating the safety of ixazomib targeting plasma cells in relapsing-remitting and progressive multiple sclerosis; c…
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CLINICAL_TRIALS research · 2025-07-28Clinical Trial Update: Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis [Phase 3]
A Phase 3 non-inferiority trial comparing ocrelizumab with rituximab in active multiple sclerosis is described; the study is currently activ…
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: ABA-101 in Participants With Progressive Multiple Sclerosis [Phase 1]
Abata Therapeutics is conducting a Phase 1 clinical trial of ABA-101 in participants with progressive multiple sclerosis. The study status i…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration [Phase 2]
This is a Phase 2 add-on trial evaluating metformin for brain remyelination and neurodegeneration in multiple sclerosis, including primary p…
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CLINICAL_TRIALS research · 2025-06-02Clinical Trial Update: Cladribine Tablets as an Exit Therapy Strategy
A clinical trial is evaluating cladribine tablets as an exit therapy strategy for multiple sclerosis, including relapsing-remitting and seco…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: Visual Processing Speed and Objective Analysis of Ocular Movements in Multiple Sclerosis
An ongoing IOBA-sponsored study is evaluating visual processing speed and objective ocular movement analysis in individuals with Multiple Sc…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Study of NG01 Cell Therapy in Secondary Progressive Multiple Sclerosis [Phase 2]
A Phase 2 clinical trial evaluating NG01 cell therapy for Secondary Progressive Multiple Sclerosis by NeuroGenesis Ltd is not yet recruiting…
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: Identification of Retinal Perivascular Inflammation in Patients With Multiple Sclerosis Using Adaptive Optics (RETIMUS) [NA]
A completed clinical trial (RETIMUS) investigating the detection of retinal perivascular inflammation in multiple sclerosis patients using a…
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CLINICAL_TRIALS research · 2025-03-28Clinical Trial Update: A Study of Allogeneic Hematopoietic Cell Transplantation for Primary Progressive Multiple Sclerosis [Phase 1]
This update describes a Phase 1 study evaluating allogeneic hematopoietic cell transplantation for primary progressive multiple sclerosis, w…
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CLINICAL_TRIALS research · 2025-01-13Clinical Trial Update: KYSA-7: A Study of Anti-CD19 CAR T-Cell Therapy, in Subjects With Refractory Primary and Secondary Progressive Multiple Sclerosis [Phase 2]
This is a Phase 2 clinical trial update for KYSA-7, an anti-CD19 CAR T-cell therapy from Kyverna Therapeutics, studied in adults with refrac…
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CLINICAL_TRIALS research · 2024-10-16Clinical Trial Update: Effects of Transcranial Static Magnetic Field Stimulation (tSMS) in Progressive Multiple Sclerosis [NA]
A clinical trial is ongoing to evaluate the effects of transcranial static magnetic field stimulation in progressive multiple sclerosis. The…
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: A Real-world Study to Assess the Use of Siponimod in Spain to Treat Patients With Secondary Progressive Multiple Sclerosis
A completed real-world study conducted in Spain evaluating the use of siponimod for secondary progressive multiple sclerosis.
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CLINICAL_TRIALS research · 2024-07-24Clinical Trial Update: Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis
This trial update describes the development of a camera-based gait quality measure for people with multiple sclerosis and notes that recruit…
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CLINICAL_TRIALS research · 2024-07-03Clinical Trial Update: Telerehabilitation in Progressive Multiple Sclerosis [NA]
A telerehabilitation clinical trial for progressive multiple sclerosis, sponsored by Universita di Verona, has not yet started recruiting.
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CLINICAL_TRIALS research · 2024-05-21Clinical Trial Update: Serial Collection of Primary Progressive Multiple Sclerosis Participants in the MURDOCK Study
This update reports the completion of serial collection from participants with Primary Progressive Multiple Sclerosis in the MURDOCK study.
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CLINICAL_TRIALS research · 2024-05-09Clinical Trial Update: Remote Ischemic Conditioning in PPMS [NA]
A clinical trial is evaluating remote ischemic conditioning for primary progressive multiple sclerosis and is not yet recruiting.
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CLINICAL_TRIALS research · 2021-05-19Clinical Trial Update: Idebenone for Primary Progressive Multiple Sclerosis [Phase 1, Phase 2]
Clinical trial update on idebenone for primary progressive multiple sclerosis completed with results posted.
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CLINICAL_TRIALS research · 2018-06-27Clinical Trial Update: Assessment of Bone Marrow-derived Cellular Therapy in Progressive Multiple Sclerosis (ACTiMuS) [Phase 2]
Phase 2 trial update for ACTiMuS bone marrow-derived cellular therapy in progressive multiple sclerosis. The current status is unknown.
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CLINICAL_TRIALS research · 2018-03-22Clinical Trial Update: Investigating Indirect Mechanism of Neuroprotection of Tecfidera® (Dimethyl Fumarate) in RRMS and Progressive Patients [Phase 4]
Phase 4 clinical trial update examining indirect neuroprotective effects of Tecfidera (dimethyl fumarate) in relapsing-remitting and progres…
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CLINICAL_TRIALS research · 2012-11-28Clinical Trial Update: Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Progressive Multiple Sclerosis and Neuromyelitis Optica [Phase 1, Phase 2]
This clinical trial update reports on the safety and efficacy evaluation of Umbilical Cord Mesenchymal Stem Cell Therapy for patients with P…
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CLINICAL_TRIALS research · 2012-11-15Clinical Trial Update: BetaPlus Survey - Observational Study to Assess Drug Adherence in Patients With Multiple Sclerosis After Conversion to Betaferon® by Using Elements of the BetaPlus Program
This completed observational trial evaluates adherence to Betaferon (interferon beta-1b) in patients with relapsing-remitting or secondary-p…