Schistosomiasis
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CLINICAL_TRIALS trial_result · 2026-04-29Clinical Trial Results: A Study to Evaluate the Safety, Tolerability, and Immunogenicity of the rSm-p80 + GLA-SE (SchistoShield®) Candidate Vaccine in Healthy Adults in Burkina Faso and Madagascar [Phase 1]
Phase 1 trial evaluating safety, tolerability, and immunogenicity of the rSm-p80 + GLA-SE (SchistoShield) vaccine in healthy adults in Burki…
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: Praziquantel in Children Under Age 4 [Phase 2]
Phase 2 trial evaluating praziquantel in children under age 4 for schistosomiasis (including Schistosoma mansoni and Schistosoma japonicum i…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Protocol for Integrating Mass Drug Administration Into Primary Health Care in Western Kenya [NA]
This document describes the protocol for integrating mass drug administration for soil-transmitted helminth infections and schistosomiasis i…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Prevalence and Molecular Identification of Human Schistosomiasis
The update describes a trial from Assiut University investigating the prevalence and molecular identification of human schistosomiasis, whic…
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CLINICAL_TRIALS trial_result · 2026-02-05Clinical Trial Update: A Study to Evaluate the Safety, Tolerability, and Immunogenicity of the Sm-p80 + GLA-SE (SchistoShield®) Candidate Vaccine in Healthy Adults in Burkina Faso and Madagascar [Phase 1]
A Phase 1 trial completed in Burkina Faso and Madagascar evaluating the safety, tolerability, and immunogenicity of the Sm-p80 + GLA-SE vacc…
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CLINICAL_TRIALS trial_result · 2025-11-04Clinical Trial Update: Sm-TSP-2 Schistosomiasis Vaccine in Healthy Ugandan Adults [Phase 1, Phase 2]
This clinical trial update reports the completion of a Phase 1/2 study evaluating the Sm-TSP-2 vaccine for schistosomiasis in healthy Uganda…
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CLINICAL_TRIALS trial_result · 2025-10-10Clinical Trial Update: Health Education Model Led by Community Health Volunteers. [NA]
A completed clinical trial in Zanzibar evaluated a community health volunteer–led health education model for schistosomiasis control; result…
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Introduction of Arpraziquantel Treatment for Schistosomiasis Control in Preschool-aged Children in Endemic Areas: A Small-scale Public Health Intervention Study
This is a small-scale public health trial assessing arpraziquantel for schistosomiasis control in preschool-aged children in endemic areas; …
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Burden of Schistosomiasis and Soil-transmitted Helminth Infections in Schoolchildren in Banfora, Burkina Faso
This clinical trial update reports on the burden of schistosomiasis and soil-transmitted helminth infections among schoolchildren in Banfora…
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CLINICAL_TRIALS trial_result · 2025-05-13Clinical Trial Update: Delivering a Multi-disease Screening Tool to Migrant Populations [NA]
This update reports the completion of a trial evaluating a multi-disease screening tool for migrant populations. The study targeted HIV, hep…
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CLINICAL_TRIALS research · 2025-04-20Clinical Trial Update: Assessment of Infection Activity in Travelers and Migrants Diagnosed With Chronic Schistosomiasis [NA]
A clinical trial update focusing on infection activity in travelers and migrants with chronic schistosomiasis; recruitment is ongoing.
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CLINICAL_TRIALS trial_result · 2025-04-11Clinical Trial Update: Safety, Tolerability, and Immunogenicity Study of Sm-p80 + GLA-SE (SchistoShield(R)) Vaccine in Healthy Adults [Phase 1]
Phase 1 study evaluating safety, tolerability, and immunogenicity of the Sm-p80 + GLA-SE SchistoShield vaccine in healthy adults; the trial …
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CLINICAL_TRIALS research · 2025-02-14Clinical Trial Update: Female Genital Schistosomiasis in Migrant Women: A Pilot Study [NA]
This clinical trial entry outlines a pilot study on diagnosing female genital schistosomiasis in migrant women. The study is not yet recruit…
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CLINICAL_TRIALS research · 2024-08-19Clinical Trial Update: Evaluation of a Comprehensive School Health Programme in Zambia [NA]
Status update on an ongoing trial in Zambia evaluating a comprehensive school health programme targeting helminth infections, malaria and re…
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CLINICAL_TRIALS trial_result · 2024-03-21Clinical Trial Update: L-PZQ ODT in Schistosoma Infected Children [Phase 3]
Phase 3 trial update for L-PZQ ODT in children infected with schistosomiasis; study completed with results posted in 2024.
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FDA approval · 2023-12-19FDA Approved: BILTRICIDE — Supplemental Application (Bayer HealthCare Pharmaceuticals Inc.)
FDA approved a supplemental application for Biltricide (praziquantel) to update the label with expanded indications for treating helminth in…
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EMA approval · 2023-12-15New treatment for young children with parasitic disease schistosomiasis
EMA CHMP adopted a positive scientific opinion for Arpraziquantel to treat schistosomiasis in young children aged 3 months to 6 years.
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CLINICAL_TRIALS trial_result · 2023-10-17Clinical Trial Update: Sm-p80 Schistosomiasis Challenge Study [Phase 2]
Phase 2 clinical trial update for Sm-p80 Schistosomiasis challenge study investigating Schistosoma mansoni and schistosomiasis.
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CLINICAL_TRIALS trial_result · 2022-04-14Clinical Trial Update: Seropositivity and Adverse Birth Events in Migrants From Bilharzia-endemic Areas
A terminated clinical trial from Jena University Hospital assessing seropositivity and adverse birth events in migrants from bilharzia-endem…
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CLINICAL_TRIALS trial_result · 2021-07-27Clinical Trial Update: Schistosomiasis Diagnosis Using a CAA Antigen Test [Phase 3]
Phase 3 trial update evaluating a CAA antigen test for diagnosing schistosomiasis; status currently unknown.
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CLINICAL_TRIALS trial_result · 2021-04-05Clinical Trial Update: Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children [Phase 3]
Phase 3 trial evaluating artesunate-mefloquine as a novel alternative treatment for schistosomiasis in African children (completed).
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CLINICAL_TRIALS trial_result · 2020-11-18Clinical Trial Update: Repeated Doses of Praziquantel in Schistosomiasis Treatment (RePST) [Phase 3]
Phase 3 trial evaluating repeated doses of praziquantel for schistosomiasis completed.
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CLINICAL_TRIALS trial_result · 2020-10-19Clinical Trial Update: Selexipag for the Treatment of Schistosomiasis-Associated Pulmonary Arterial Hypertension [Phase 2]
Phase 2 trial update for selexipag in schistosomiasis-associated pulmonary arterial hypertension is reported as ongoing with unknown status.
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CLINICAL_TRIALS trial_result · 2020-05-18Clinical Trial Update: Treatment of Female Genital Schistosomiasis (FGS) With Praziquantel: A Proof-of-Concept Study [Phase 2, Phase 3]
A proof-of-concept study assessing praziquantel for treatment of female genital schistosomiasis (FGS) in Phase 2/Phase 3.
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CLINICAL_TRIALS withdrawal · 2019-12-17Clinical Trial Update: Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis [Phase 4]
A Phase 4 clinical trial evaluating the effect of concomitant Mansonella perstans microfilaremia on immune responses after a single-dose pra…